All Phenotypes Zap70<tm1Weis> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Zap70^tm1Weis
targeted mutation 1, Arthur Weiss
MGI:2176252

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zap70^tm1Weis/Zap70^tm1Weis	involves: 129X1/SvJ * C57BL/6J	MGI:3620119
ht2	Zap70^m6Hefl/Zap70^tm1Weis	involves: 129X1/SvJ * C3HeB/FeJ * C57BL/10 * DBA/2	MGI:3802707
cx3	Sla^tm1Weis/Sla^tm1Weis Zap70^tm1Weis/Zap70^tm1Weis	involves: 129 * 129X1/SvJ * C57BL/6	MGI:3033126

Allelic Composition	Zap70^tm1Weis/Zap70^tm1Weis
Genetic Background	involves: 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zap70^tm1Weis mutation (2 available); any Zap70 mutation (55 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal T cell differentiation ( J:74974 )

• the number of dendritic epidermal T cells is reduced and those cells present lack the characteristic dendritic extensions

• few intestinal intraepithelial lymphocytes express gamma delta or alpha beta T cell receptors

arrested T cell differentiation ( J:74974 )

• arrest at the double positive stage

abnormal splenic cell ratio ( J:74974 )

• spleens are composed of mostly B cells

abnormal lymph node cell ratio ( J:74974 )

• lymph nodes contain mostly B cells and a significant percentage of CD3+ (but CD4- and CD8-) cells which are primarily gamma delta T cells

• the percentage of gamma delta T cells is increased but the absolute number of these cell is similar to wild-type

small lymph nodes ( J:74974 )

hematopoietic system

abnormal T cell differentiation ( J:74974 )

• the number of dendritic epidermal T cells is reduced and those cells present lack the characteristic dendritic extensions

• few intestinal intraepithelial lymphocytes express gamma delta or alpha beta T cell receptors

arrested T cell differentiation ( J:74974 )

• arrest at the double positive stage

abnormal splenic cell ratio ( J:74974 )

• spleens are composed of mostly B cells

Allelic Composition	Zap70^m6Hefl/Zap70^tm1Weis
Genetic Background	involves: 129X1/SvJ * C3HeB/FeJ * C57BL/10 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zap70^m6Hefl mutation (0 available); any Zap70 mutation (55 available)
Zap70^tm1Weis mutation (2 available); any Zap70 mutation (55 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased T cell number ( J:137446 )

• peripheral T cells are dramatically reduced compared to in wild-type mice

increased IgE level ( J:137446 )

immune system

decreased T cell number ( J:137446 )

• peripheral T cells are dramatically reduced compared to in wild-type mice

increased IgE level ( J:137446 )

Allelic Composition	Sla^tm1Weis/Sla^tm1Weis Zap70^tm1Weis/Zap70^tm1Weis
Genetic Background	involves: 129 * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sla^tm1Weis mutation (1 available); any Sla mutation (20 available)
Zap70^tm1Weis mutation (2 available); any Zap70 mutation (55 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal T cell differentiation ( J:71804 )

• partial rescue of block at double-positive stage observed in Zap70^tm1Weis homozygotes

• thymocytes mature to the single-positive stage and proceed to become mature T cells, but overall number of mature CD4⁺ T cells is less than that of wild-type

decreased CD4-positive, alpha-beta T cell number ( J:71804 )

• thymocytes mature to the single-positive stage and proceed to become mature T cells, but overall number of mature CD4⁺ T cells is less than that of wild-type

hematopoietic system

abnormal T cell differentiation ( J:71804 )

• partial rescue of block at double-positive stage observed in Zap70^tm1Weis homozygotes

• thymocytes mature to the single-positive stage and proceed to become mature T cells, but overall number of mature CD4⁺ T cells is less than that of wild-type

decreased CD4-positive, alpha-beta T cell number ( J:71804 )

• thymocytes mature to the single-positive stage and proceed to become mature T cells, but overall number of mature CD4⁺ T cells is less than that of wild-type

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