Phenotypes associated with this allele

• Allele Symbol: Aatf^{Gt(pGT1.8geo)3Pgr}
• Allele Name: gene trap 3, Peter Gruss
• Allele ID: MGI:2176283
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Aatf^Gt(pGT1.8geo)3Pgr/Aatf^Gt(pGT1.8geo)3Pgr	either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * NMRI)	MGI:2176341

Genotype
MGI:2176341

hm1

• Allelic Composition: Aatf^{Gt(pGT1.8geo)3Pgr}/Aatf^{Gt(pGT1.8geo)3Pgr}
• Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * NMRI)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:65741 )

• embryos die after failing to undergo compaction

embryo

abnormal preimplantation embryo development ( J:65741 )

failure of blastocyst formation ( J:65741 )

• E1.5 embryos cultured in vitro do not form blastocysts, unlike wild type embryos

failure of morula compaction ( J:65741 )

• E1.5 embryos cultured in vitro start to decompact and die after 72 hours of culture

embryonic growth arrest ( J:65741 )

• development is arrested at the compacted morula stage at E2.5

decreased embryo size ( J:65741 )

• 50% reduction in total cell number

absent blastocoele ( J:65741 )

• embryos have not formed a blastocoel cavity by E3.5

growth/size/body

decreased embryo size ( J:65741 )

• 50% reduction in total cell number

cellular

abnormal intracellular organelle morphology ( J:65741 )

• embryos have few ribosomes, polyribosomes, and rough endoplasmic reticulum

• greatly enlarged secretory vesicles are seen in embryos

abnormal ribosome morphology ( J:65741 )

• decreased number of ribosomes

decreased cell proliferation ( J:65741 )

• embryos exhibit severe reduction in cell proliferation before blastocyst formation