Phenotypes associated with this allele

• Allele Symbol: Pdyn^tm1Ute
• Allele Name: targeted mutation 1, Ute Hochgeschwender
• Allele ID: MGI:2176368
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pdyn^tm1Ute/Pdyn^tm1Ute	B6.129S4-Pdyn^tm1Ute	MGI:3043149
hm2	Pdyn^tm1Ute/Pdyn^tm1Ute	involves: 129S4/SvJae * 129S6/SvEvTac	MGI:2176382

Genotype
MGI:3043149

hm1

• Allelic Composition: Pdyn^tm1Ute/Pdyn^tm1Ute
• Genetic Background: B6.129S4-Pdyn^tm1Ute

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired conditioned place preference behavior ( J:84344 )

• mutant mice exhibit much lower response than controls in cocaine place preference tests

abnormal anxiety-related response ( J:84344 )

• forced swim test had no effect on tail withdrawl latency unlike controls where latency increased

decreased anxiety-related response ( J:84344 )

• reduced immobility on second and later forced swim test trials

• swim stressed mice were much like unstressed mice

Genotype
MGI:2176382

hm2

• Allelic Composition: Pdyn^tm1Ute/Pdyn^tm1Ute
• Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

behavior/neurological

abnormal touch/ nociception ( J:67584 )

abnormal response to tactile stimuli ( J:67584 )

• small but significant decrease in tail flick response latency

• enhanced second phase paw flinch response after injection of 2% formalin

• increased sensitivity to mechanical stimulation after spinal nerve ligation at L5/L6 returned to normal by day 14 after surgery rather than persisting as in controls

abnormal thermal nociception ( J:67584 )

• increased sensitivity to heat stimulation after spinal nerve ligation at L5/L6 returned to normal by day 9 after surgery rather than persisting as in controls