All Phenotypes Ptpn1<tm1Bpk> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ptpn1^tm1Bpk
targeted mutation 1, Brian P Kennedy
MGI:2176520

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ptpn1^tm1Bpk/Ptpn1^tm1Bpk	involves: 129S4/SvJae * BALB/c	MGI:2176521
ht2	Ptpn1^tm1Bpk/Ptpn1⁺	involves: 129S4/SvJae * BALB/c	MGI:3611841
cn3	Pten^tm1Hwu/Pten^tm1Hwu Ptpn1^tm1Bpk/Ptpn1^tm1Bpk Tg(Pbsn-cre)4Prb/0	involves: 129S4/SvJae * C57BL/6 * DBA/2	MGI:6378626

Allelic Composition	Ptpn1^tm1Bpk/Ptpn1^tm1Bpk
Genetic Background	involves: 129S4/SvJae * BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptpn1^tm1Bpk mutation (0 available); any Ptpn1 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:53437 )

• substantially protected from diet-induced weight gain and maintain normal glucose and insulin concentrations while on the high-fat diet, even though they consume a similar amount of food as wild-type

decreased circulating glucose level ( J:53437 )

• in the fed, but not fasted state, exhibit a 13% reduction in blood glucose concentration, however, brain, liver, muscle, pancreas, testes, and fertility are normal

decreased circulating insulin level ( J:53437 )

• in the fed, but not fasted state, insulin levels are about half of those of controls

improved glucose tolerance ( J:53437 )

increased insulin sensitivity ( J:53437 )

• more rapid clearance of glucose in oral glucose and intraperitoneal insulin tolerance tests

decreased triglyceride level ( J:53437 )

• lower triglyceride levels on either a regular or high-fat diet

growth/size/body

decreased susceptibility to diet-induced obesity ( J:53437 )

Allelic Composition	Ptpn1^tm1Bpk/Ptpn1⁺
Genetic Background	involves: 129S4/SvJae * BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptpn1^tm1Bpk mutation (0 available); any Ptpn1 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:53437 )

• exhibit protection from diet-induced weight gain and although they show increased fasting glucose concentrations of insulin, they maintain normal glucose levels

decreased circulating glucose level ( J:53437 )

• in the fed state, exhibit an 8% reduction in blood glucose concentration, however do not exhibit an altered glucose tolerance

growth/size/body

decreased susceptibility to diet-induced obesity ( J:53437 )

• exhibit protection from diet-induced weight gain and although they show increased fasting glucose concentrations of insulin, they maintain normal glucose levels

Allelic Composition	Pten^tm1Hwu/Pten^tm1Hwu Ptpn1^tm1Bpk/Ptpn1^tm1Bpk Tg(Pbsn-cre)4Prb/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pten^tm1Hwu mutation (16 available); any Pten mutation (88 available)
Ptpn1^tm1Bpk mutation (0 available); any Ptpn1 mutation (36 available)
Tg(Pbsn-cre)4Prb mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

increased prostate gland adenocarcinoma incidence ( J:231906 )

• one mouse at 6 weeks of age shows a microinvasive adenocarcinoma

• mice fed a high-fat diet upon weaning show an increase in the penetrance and number of microinvasive foci of microinvasive adenocarcinoma

increased prostate intraepithelial neoplasia incidence ( J:231906 )

• mice show a similar number of prostate ductules affected by intraepithelial neoplasia (mPIN) as single Pten^tm1Hwu conditional mice

neoplasm

increased prostate gland adenocarcinoma incidence ( J:231906 )

• one mouse at 6 weeks of age shows a microinvasive adenocarcinoma

• mice fed a high-fat diet upon weaning show an increase in the penetrance and number of microinvasive foci of microinvasive adenocarcinoma

increased prostate intraepithelial neoplasia incidence ( J:231906 )

• mice show a similar number of prostate ductules affected by intraepithelial neoplasia (mPIN) as single Pten^tm1Hwu conditional mice

reproductive system

increased prostate gland adenocarcinoma incidence ( J:231906 )

• one mouse at 6 weeks of age shows a microinvasive adenocarcinoma

• mice fed a high-fat diet upon weaning show an increase in the penetrance and number of microinvasive foci of microinvasive adenocarcinoma

increased prostate intraepithelial neoplasia incidence ( J:231906 )

• mice show a similar number of prostate ductules affected by intraepithelial neoplasia (mPIN) as single Pten^tm1Hwu conditional mice

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