Phenotypes associated with this allele

• Allele Symbol: Selplg^tm1Fur
• Allele Name: targeted mutation 1, Bruce Furie
• Allele ID: MGI:2176571
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Selplg^tm1Fur/Selplg^tm1Fur	involves: 129/Sv * C57BL/6J * SJL	MGI:2176573
cx2	Fas^lpr/Fas^lpr Selplg^tm1Fur/Selplg^tm1Fur	MRL.Cg-Selplg^tm1Fur Fas^lpr	MGI:3800806

Genotype
MGI:2176573

hm1

• Allelic Composition: Selplg^tm1Fur/Selplg^tm1Fur
• Genetic Background: involves: 129/Sv * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

impaired neutrophil chemotaxis ( J:75412 )

• during experimental peritonitis

impaired leukocyte tethering or rolling ( J:75412 )

• impaired

increased eosinophil cell number ( J:75412 )

• 3.5-fold higher than in wild-type mice

increased neutrophil cell number ( J:75412 )

• 2.9-fold higher than in wild-type mice

hematopoietic system

impaired neutrophil chemotaxis ( J:75412 )

• during experimental peritonitis

impaired leukocyte tethering or rolling ( J:75412 )

• impaired

increased eosinophil cell number ( J:75412 )

• 3.5-fold higher than in wild-type mice

increased neutrophil cell number ( J:75412 )

• 2.9-fold higher than in wild-type mice

cellular

impaired neutrophil chemotaxis ( J:75412 )

• during experimental peritonitis

impaired leukocyte tethering or rolling ( J:75412 )

• impaired

Genotype
MGI:3800806

cx2

• Allelic Composition: Fas^lpr/Fas^lpr; Selplg^tm1Fur/Selplg^tm1Fur
• Genetic Background: MRL.Cg-Selplg^tm1Fur Fas^lpr

mortality/aging

premature death ( J:127199 )

• overall survival is reduced compared to Fas^lpr homozygotes (median survival is 21 weeks vs 26 weeks for Fas mutants); renal lesions are severe at time of death

immune system

abnormal chemokine level ( J:127199 )

• significant increases are observed at 16 weeks, in contrast to Selp-null, Fas double mutants; levels are significantly higher than control at 20 weeks

glomerulonephritis ( J:127199 )

• at 20 weeks of age, kidneys display higher lesion scores than controls

dermatitis ( J:127199 )

• double mutants show more rapid onset of cutaneous inflammation than Fas^lpr homozygotes

renal/urinary system

glomerulonephritis ( J:127199 )

• at 20 weeks of age, kidneys display higher lesion scores than controls

homeostasis/metabolism

abnormal chemokine level ( J:127199 )

• significant increases are observed at 16 weeks, in contrast to Selp-null, Fas double mutants; levels are significantly higher than control at 20 weeks

integument

dermatitis ( J:127199 )

• double mutants show more rapid onset of cutaneous inflammation than Fas^lpr homozygotes