All Phenotypes Il4<tm1Lky> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Il4^tm1(CD2)Mmrs/Il4^tm1Lky	involves: 129/Sv * C57BL/6	MGI:3687996
cx2	Il4^tm1Lky/Il4⁺ Lat^tm1.1Mal/Lat^tm1.1Mal	involves: 129S2/SvPas * C57BL/6	MGI:4357974
cx3	Il4^tm1Lky/Il4^tm1Lky Itk^tm1Litt/Itk^tm1Litt	involves: 129S4/SvJae * BALB/c * C57BL/6J	MGI:3771807

Allelic Composition	Il4^tm1(CD2)Mmrs/Il4^tm1Lky
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4^tm1(CD2)Mmrs mutation (0 available); any Il4 mutation (46 available)
Il4^tm1Lky mutation (3 available); any Il4 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:113279 )

• mice are viable; dual-reporter mice were used for detailed profiling of Il4 mRNA and protein production in response to stimulation in culture and parasitic infection in vivo

Allelic Composition	Il4^tm1Lky/Il4⁺ Lat^tm1.1Mal/Lat^tm1.1Mal
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4^tm1Lky mutation (3 available); any Il4 mutation (46 available)
Lat^tm1.1Mal mutation (0 available); any Lat mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal T-helper 2 physiology ( J:151840 )

• the first CD4⁺ T cells that seed the periphery in newborn mice undergo rapid expansion and convert into pathogenic Th2 effector cells

hematopoietic system

abnormal T-helper 2 physiology ( J:151840 )

• the first CD4⁺ T cells that seed the periphery in newborn mice undergo rapid expansion and convert into pathogenic Th2 effector cells

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:129883 )

N	• both Th1 and Th2 programs can be induced in Itk-null cells when Th1 priming or Th2 priming conditions are used

abnormal T-helper 2 physiology ( J:129883 )

• upon restimulation with anti-TCR antibodies, numbers of Il4 (EGFP) expressing cells remains constant (~65%, elevated relative to wild-type cells) but Il4 protein production is markedly attenuated; however if TCR-mediated signaling is bypassed with stimulation by PMA/ionomycin, Th2-primed null cells show similar levels of Il4 secretion to wild-type cells

• similar results are obtained in vivo

abnormal cytokine secretion ( J:129883 )

• only Th1-primed cells can secrete effector cytokines (interferon gamma) upon restimulation; Th2-primed cells do not secrete Il4 upon restimulation as shown by Il4 reporter expression

• similar results are obtained in vivo

• after infection with Leishmania major, restimulation with L. major antigens reveals defects in Il4 production

abnormal response to infection ( J:129883 )

• after infection with Leishmania major, restimulation with L. major antigens reveals defects in Il4 production

cellular

abnormal cell death ( J:129883 )

• fewer Itk-null lymphocytes undergo activation induced cell death than wild-type cells upon restimulation

hematopoietic system

abnormal T-helper 2 physiology ( J:129883 )

• similar results are obtained in vivo

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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