Phenotypes associated with this allele

• Allele Symbol: Adm^tm1Unc
• Allele Name: targeted mutation 1, University of North Carolina
• Allele ID: MGI:2176598
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adm^tm1Unc/Adm^tm1Unc	129S6/SvEvTac-Adm^tm1Unc	MGI:3772944
hm2	Adm^tm1Unc/Adm^tm1Unc	involves: 129S6/SvEvTac	MGI:2176599
ht3	Adm^tm1Unc/Adm^+	129S6/SvEvTac-Adm^tm1Unc	MGI:3763617
cx4	Adm^tm1Unc/Adm^+ Tg(Alb1-Ren)2Unc/?	129S6/SvEvTac-Adm^tm1Unc Tg(Alb1-Ren)2Unc	MGI:3763615

Genotype
MGI:3772944

hm1

• Allelic Composition: Adm^tm1Unc/Adm^tm1Unc
• Genetic Background: 129S6/SvEvTac-Adm^tm1Unc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Generalized edema in Calcrl^tm1Kmca/Calcrl^tm1Kmca, Adm^tm1Unc/Adm^tm1Unc, and Ramp2^tm1Kmca/Ramp2^tm1Kmca mice

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:130930 )

• mice die 1 to 2 days after developing edema

immune system

abnormal lymph organ development ( J:130930 )

• at E13.5, the jugular lymph sac is smaller than in wild-type mice despite lymphedema

• proliferation of lymphatic endothelial cells is decreased compared to in wild-type mice

homeostasis/metabolism

edema ( J:130930 )

• at E13.5, mice exhibit interstitial edema without hemorrhage

lymphedema ( J:130930 )

Genotype
MGI:2176599

hm2

• Allelic Composition: Adm^tm1Unc/Adm^tm1Unc
• Genetic Background: involves: 129S6/SvEvTac

Massive generalized edema of Adm^tm1Unc/Adm^tm1Unc embryos

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:67044 )

• embryos die between E13.5 and E14.5

cardiovascular system

abnormal artery morphology ( J:67044 )

• major arteries have thinner walls and are irregular in shape

abnormal myocardial trabeculae morphology ( J:67044 )

• left ventricular trabecular overdevelopment; increased number of trabeculae

disorganized myocardium ( J:67044 )

small heart ( J:67044 )

• mutant hearts are 2/3 of the normal size

abnormal heart left ventricle morphology ( J:67044 )

• the left ventricle has a thinner, convoluted compact zone

embryo

increased placenta apoptosis ( J:201446 )

• increased apoptosis in the innermost border of the maternal-fetal interface of the placenta at E13.5

• increased apoptosis of parietal trophoblast cells

decreased uterine NK cell number ( J:201446 )

abnormal placenta labyrinth morphology ( J:201446 )

• in the innermost border of the maternal-fetal interface of the placenta at E13.5

• fetal vessels are abnormally large and under-branched compared to in wild-type mice

• increase in fetal space is accompanied by a decrease in maternal sinuses

• ovary transplantation experiments demonstrate that placental defects are independent of maternal genotype

• however, the total area of vascular space is normal

abnormal placenta fetal blood space morphology ( J:201446 )

• fetal sinuses of the placenta are larger than in wild-type mice

abnormal placenta intervillous maternal lacunae morphology ( J:201446 )

• decreased in maternal sinuses

abnormal visceral yolk sac morphology ( J:67044 )

• cavity distended

homeostasis/metabolism

hydrops fetalis ( J:67044 , J:106927 )

• general edema, associated with increased size of thoracic cavity (J:67044)

• onset of edema occurs at E13.5 (J:106927)

muscle

abnormal myocardial trabeculae morphology ( J:67044 )

• left ventricular trabecular overdevelopment; increased number of trabeculae

disorganized myocardium ( J:67044 )

increased cardiomyocyte apoptosis ( J:106927 )

• by E13.5, see a 6-fold increase in apoptosis throughout the heart, particularly in the ventricular apex, endocardial cushion, and septum

cellular

increased cardiomyocyte apoptosis ( J:106927 )

• by E13.5, see a 6-fold increase in apoptosis throughout the heart, particularly in the ventricular apex, endocardial cushion, and septum

increased placenta apoptosis ( J:201446 )

• increased apoptosis in the innermost border of the maternal-fetal interface of the placenta at E13.5

• increased apoptosis of parietal trophoblast cells

hematopoietic system

decreased uterine NK cell number ( J:201446 )

immune system

decreased uterine NK cell number ( J:201446 )

reproductive system

decreased uterine NK cell number ( J:201446 )

abnormal uterine spiral artery remodeling ( J:201446 )

• reduced maternal spiral artery remodeling with thick smooth muscle layer throughout the decidua

• reduced proliferation of endothelial cells in spiral arteries and failure to shed smooth muscle cells

endocrine/exocrine glands

decreased uterine NK cell number ( J:201446 )

Genotype
MGI:3763617

ht3

• Allelic Composition: Adm^tm1Unc/Adm⁺
• Genetic Background: 129S6/SvEvTac-Adm^tm1Unc

cardiovascular system

cardiovascular system phenotype ( J:125933 )

N • blood pressure under resting conditions and hypotension induced by pregnancy or after LPS treatment is normal

Genotype
MGI:3763615

cx4

• Allelic Composition: Adm^tm1Unc/Adm⁺; Tg(Alb1-Ren)2Unc/?
• Genetic Background: 129S6/SvEvTac-Adm^tm1Unc Tg(Alb1-Ren)2Unc

cardiovascular system

increased myocardial fiber size ( J:125933 )

• male cardiomyocytes are larger than in Tg(Alb1-Ren)1Unc male mice

• however, there is no difference in cardiomyocyte size in female mice compared to Tg(Alb1-Ren)1Unc female mice

cardiac hypertrophy ( J:125933 )

• male mice exhibit increased cardiac hypertrophy compared to Tg(Alb1-Ren)1Unc male mice

• however, female mice are not significantly different in terms of cardiac hypertrophy compared to female mice containing Tg(Alb1-Ren)1Unc and the degree of coronary artery fibrosis is the same as in Tg(Alb1-Ren)1Unc mice regardless of gender

increased systemic arterial blood pressure ( J:125933 )

• 149+/-12 mmHg compared to 108+/-9 mmHg in wild-type mice

• however, blood pressure is not significantly different from Tg(Alb1-Ren)1Unc containing mice

renal/urinary system

glomerulosclerosis ( J:125933 )

• glomerulosclerosis is worse in male mice than in Tg(Alb1-Ren)1Unc male mice

• however, there is no difference in glomerulosclerosis in female mice compared to Tg(Alb1-Ren)1Unc female mice

renal cast ( J:125933 )

• presence of proteinacious casts is worse in male mice than in Tg(Alb1-Ren)1Unc male mice

• however, there is no difference in presence of proteinacious casts in female mice compared to Tg(Alb1-Ren)1Unc female mice

renal fibrosis ( J:125933 )

• renal fibrosis is worse in male mice than in Tg(Alb1-Ren)1Unc male mice

• however, there is no difference in renal fibrosis in female mice compared to Tg(Alb1-Ren)1Unc female mice

muscle

increased myocardial fiber size ( J:125933 )

• male cardiomyocytes are larger than in Tg(Alb1-Ren)1Unc male mice

• however, there is no difference in cardiomyocyte size in female mice compared to Tg(Alb1-Ren)1Unc female mice

growth/size/body

cardiac hypertrophy ( J:125933 )

• male mice exhibit increased cardiac hypertrophy compared to Tg(Alb1-Ren)1Unc male mice

• however, female mice are not significantly different in terms of cardiac hypertrophy compared to female mice containing Tg(Alb1-Ren)1Unc and the degree of coronary artery fibrosis is the same as in Tg(Alb1-Ren)1Unc mice regardless of gender