All Phenotypes Fhit<tm1Hbn> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fhit^tm1Hbn/Fhit^tm1Hbn	involves: 129X1/SvJ * C57BL/6	MGI:3029764
ht2	Fhit^tm1Hbn/Fhit⁺	involves: 129X1/SvJ * C57BL/6	MGI:3029765
cx3	Fhit^tm1Hbn/Fhit^tm1Hbn Hint1^tm1.1Tpm/Hint1^tm1.1Tpm	involves: 129X1/SvJ * BALB/c * C57BL/6	MGI:2663686
cx4	Fhit^tm1Hbn/Fhit^tm1Hbn Hint1^tm1.1Tpm/Hint1⁺	involves: 129X1/SvJ * BALB/c * C57BL/6	MGI:2663691

Allelic Composition	Fhit^tm1Hbn/Fhit^tm1Hbn
Genetic Background	involves: 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fhit^tm1Hbn mutation (0 available); any Fhit mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:71303 )

• 29% of heterozygous mice were found dead before normal life span with evidence of widespread infections

neoplasm

increased tumor incidence ( J:71303 )

• in untreated mice, the incidence of spontaneous tumors of various types was 53%

increased incidence of tumors by chemical induction ( J:71303 )

• 89% of mice exhibit large sebaceous tumors after a single dose of NMBA, especially in the gastrointestinal tract

hematopoietic system

decreased granulocyte number ( J:71303 )

• granulocyte numbers are 2-6% of total blood lymphocytes; controls granulocyte numbers are 15% of total

immune system

decreased granulocyte number ( J:71303 )

• granulocyte numbers are 2-6% of total blood lymphocytes; controls granulocyte numbers are 15% of total

increased susceptibility to infection ( J:71303 )

• mice exhibit evidence of widespread infections and abcesses

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:71303 )

• 89% of mice exhibit large sebaceous tumors after a single dose of NMBA, especially in the gastrointestinal tract

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:71303 )

• 26% of heterozygous mice were found dead before normal life span with evidence of widespread infections

neoplasm

increased tumor incidence ( J:71303 )

• in untreated mice, the incidence of spontaneous tumors of various types was 53%

increased incidence of tumors by chemical induction ( J:61946 , J:71303 , J:110096 )

• 10 weeks after NMBA treatment, all heterozygous mice exhibited tumors in various tissues, especially the gastrointestinal tract including the forestomach and squamocolumnar juction; the incidence of tumors in control mice was 25% (J:61946)

• 78% of mice exhibit large sebaceous tumors after a single dose of NMBA, especially in the gastrointestinal tract (J:71303)

• mutants develop preneoplastic lesions of the uterus more frequently than wild-type after multiple doses of benzol[a]pyrene (B[a]P), however develop similar levels of forestomach and lung tumors (J:110096)

hematopoietic system

decreased granulocyte number ( J:71303 )

• granulocyte numbers are 2-6% of total blood lymphocytes; controls granulocyte numbers are 15% of total

immune system

decreased granulocyte number ( J:71303 )

• granulocyte numbers are 2-6% of total blood lymphocytes; controls granulocyte numbers are 15% of total

increased susceptibility to infection ( J:71303 )

• mice exhibit evidence of widespread infections and abcesses

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:61946 , J:71303 , J:110096 )

• 78% of mice exhibit large sebaceous tumors after a single dose of NMBA, especially in the gastrointestinal tract (J:71303)

integument

alopecia ( J:110096 )

• spontaneous alopecia areata and hair bulb cell apoptosis are greatly accelerated in mutants compared to wild-type

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Muir-Torre syndrome		DOID:0050465	OMIM:158320	J:61946

Allelic Composition	Fhit^tm1Hbn/Fhit^tm1Hbn Hint1^tm1.1Tpm/Hint1^tm1.1Tpm
Genetic Background	involves: 129X1/SvJ * BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fhit^tm1Hbn mutation (0 available); any Fhit mutation (22 available)
Hint1^tm1.1Tpm mutation (0 available); any Hint1 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased tumor incidence ( J:83562 )

• a small number of extraintestinal tumors and neoplasias were observed; spectrum was similar to that noted in Fhit deficient mice

Allelic Composition	Fhit^tm1Hbn/Fhit^tm1Hbn Hint1^tm1.1Tpm/Hint1⁺
Genetic Background	involves: 129X1/SvJ * BALB/c * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased tumor incidence ( J:83562 )

• a small number of extraintestinal tumors and neoplasias were observed; spectrum was similar to that noted in Fhit deficient mice

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