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Allele Symbol Allele Name Allele ID |
Arnttm1Gonz targeted mutation 1, Frank Gonzalez MGI:2176696 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• induction of Cyp1A1 and Cyp1a2 by TCDD is absent from the liver, in addition Cyp1a2 constitutive expression is decreased
• hepatic induction of Slc2a1, Aldoa, and Hmox1 by CoCl2, which mimics physiological hypoxia, is variably reduced
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mammary gland development is normal and females are able to raise litters even after several pregnancies
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• incomplete development of alveoli probably secondary to impaired ovarian function as tissue transplanted into athymic nude mice develops normally
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• contain fewer primordial follicles but similar numbers of primary and preantral/antral follicles compared to controls
• however estrus cycle and the levels of estradiol and progesterone are similar to controls
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• fewer primordial follicles compared to controls
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• average litter size is 4 +/- 2 pups
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• incomplete development of alveoli probably secondary to impaired ovarian function as tissue transplanted into athymic nude mice develops normally
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• contain fewer primordial follicles but similar numbers of primary and preantral/antral follicles compared to controls
• however estrus cycle and the levels of estradiol and progesterone are similar to controls
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• fewer primordial follicles compared to controls
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• 60% of dams can not support their pups and surviving pups are smaller compared to pups nursed by homozygous dams lacking Cre expression (controls)
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• incomplete development of alveoli probably secondary to impaired ovarian function as tissue transplanted into athymic nude mice develops normally
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• 60% of dams can not support their pups and surviving pups are smaller compared to pups nursed by homozygous dams lacking Cre expression (controls)
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 07/05/2024 MGI 6.24 |
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