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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Bcl2l1tm1Mam
targeted mutation 1, Lothar Hennighausen
MGI:2176699
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Bcl2l1tm1Mam/Bcl2l1tm1Mam involves: 129S6/SvEvTac * C57BL/6 MGI:2176701
cx2
 		Baxtm1Sjk/Bax+
Bcl2l1tm1Mam/Bcl2l1tm1Mam 		involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6 MGI:2176704
cx3
 		Baxtm1Sjk/Baxtm1Sjk
Bcl2l1tm1Mam/Bcl2l1tm1Mam 		involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6 MGI:2662433


Genotype
MGI:2176701
hm1
Allelic
Composition		 Bcl2l1tm1Mam/Bcl2l1tm1Mam
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l1tm1Mam mutation (0 available); any Bcl2l1 mutation (104 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
decreased primordial germ cell number ( J:63161 )
• testes and ovaries had similar numbers of primordial germ cells (PGCs) as wild-type, E12.5
• progressive reduction of PGCs, E13.5-E15.5
• testes had 85% fewer PGCs relative to wild-type, E14.5
• ovaries had 58% fewer PGCs than wild-type, E13.5
abnormal apoptosis ( J:63161 )
• increased apoptosis of gonocytes observed in both ovaries and testes at E13.5

endocrine/exocrine glands
decreased primordial ovarian follicle number ( J:63161 )
• 94% fewer primordial follicles at 9 days of age than controls
small testis ( J:63161 )
• decreased size due to an absence of spermatogonia, spermatocytes, and spermatids form the seminiferous tubules, however seminal vesicles and accessory glands were normal

reproductive system
decreased primordial germ cell number ( J:63161 )
• testes and ovaries had similar numbers of primordial germ cells (PGCs) as wild-type, E12.5
• progressive reduction of PGCs, E13.5-E15.5
• testes had 85% fewer PGCs relative to wild-type, E14.5
• ovaries had 58% fewer PGCs than wild-type, E13.5
decreased primordial ovarian follicle number ( J:63161 )
• 94% fewer primordial follicles at 9 days of age than controls
small testis ( J:63161 )
• decreased size due to an absence of spermatogonia, spermatocytes, and spermatids form the seminiferous tubules, however seminal vesicles and accessory glands were normal
reduced female fertility ( J:63161 )
• approximately 25% of females were fertile
decreased litter size ( J:63161 )
• fertile females never gave birth to more than 3 pups




Genotype
MGI:2176704
cx2
Allelic
Composition		 Baxtm1Sjk/Bax+
Bcl2l1tm1Mam/Bcl2l1tm1Mam
Genetic
Background		 involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Baxtm1Sjk mutation (1 available); any Bax mutation (24 available)
Bcl2l1tm1Mam mutation (0 available); any Bcl2l1 mutation (104 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal ovarian folliculogenesis ( J:63161 )
• decreased number of ovarian follicles

reproductive system
decreased male germ cell number ( J:63161 )
• absence of spermatogonia
abnormal ovarian folliculogenesis ( J:63161 )
• decreased number of ovarian follicles

cellular
decreased male germ cell number ( J:63161 )
• absence of spermatogonia




Genotype
MGI:2662433
cx3
Allelic
Composition		 Baxtm1Sjk/Baxtm1Sjk
Bcl2l1tm1Mam/Bcl2l1tm1Mam
Genetic
Background		 involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Baxtm1Sjk mutation (1 available); any Bax mutation (24 available)
Bcl2l1tm1Mam mutation (0 available); any Bcl2l1 mutation (104 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal ovarian folliculogenesis ( J:63161 )
• increased follicle counts relative to double heterozygous control at 1 day of age
abnormal spermatogenesis ( J:63161 )
• excessive numbers of spermatogonia and spermatocytes
• mature sperm are not produced

endocrine/exocrine glands
abnormal ovarian folliculogenesis ( J:63161 )
• increased follicle counts relative to double heterozygous control at 1 day of age

cellular




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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory