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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Bcl2l1tm1.1Mam
targeted mutation 1.1, Lothar Hennighausen
MGI:2176700
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Bcl2l1tm1Dlo/Bcl2l1tm1.1Mam
Tg(Aicda-cre)9Mbu/0 		B6.Cg-Bcl2l1tm1Dlo/Bcl2l1tm1.1Mam Tg(Aicda-cre)9Mbu MGI:4840319
cn2
 		Bak1tm1Thsn/Bak1tm1Thsn
Baxtm1Sjk/Baxtm2Sjk
Bcl2l1tm1.1Mam/Bcl2l1tm1.1Mam
Tg(MMTV-cre)#Mam/0 		involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * FVB MGI:3819938
cn3
 		Bcl2l1tm1.1Mam/Bcl2l1tm1.1Mam
Tg(Ins2-cre)25Mgn/0
Tg(RIP1-Tag)2Dh/0 		involves: 129S6/SvEvTac * C57BL/6 * DBA MGI:3843604
cn4
 		Bcl2l1tm1.1Mam/Bcl2l1tm1.1Mam
7630403G23RikTg(Th-cre)1Tmd/? 		involves: 129S6/SvEvTac * C57BL/6 * SJL MGI:3586797
cx5
 		Bcl2l1tm1.1Mam/Bcl2l1tm1.1Mam
Tg(RIP1-Tag)2Dh/0 		involves: 129S6/SvEvTac * C57BL/6 * DBA MGI:3843606


Genotype
MGI:4840319
cn1
Allelic
Composition		 Bcl2l1tm1Dlo/Bcl2l1tm1.1Mam
Tg(Aicda-cre)9Mbu/0
Genetic
Background		 B6.Cg-Bcl2l1tm1Dlo/Bcl2l1tm1.1Mam Tg(Aicda-cre)9Mbu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l1tm1.1Mam mutation (0 available); any Bcl2l1 mutation (104 available)
Bcl2l1tm1Dlo mutation (0 available); any Bcl2l1 mutation (104 available)
Tg(Aicda-cre)9Mbu mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:166069 )
N
• affinity maturation among NP-reactive B cells and germinal cell formation are normal
decreased IgG1 level ( J:166069 )
• following immunization with NP-KLH, the frequency of NP-specific IgG1 in the bone marrow compared to in similarly treated wild-type mice

hematopoietic system
decreased IgG1 level ( J:166069 )
• following immunization with NP-KLH, the frequency of NP-specific IgG1 in the bone marrow compared to in similarly treated wild-type mice




Genotype
MGI:3819938
cn2
Allelic
Composition		 Bak1tm1Thsn/Bak1tm1Thsn
Baxtm1Sjk/Baxtm2Sjk
Bcl2l1tm1.1Mam/Bcl2l1tm1.1Mam
Tg(MMTV-cre)#Mam/0
Genetic
Background		 involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bak1tm1Thsn mutation (2 available); any Bak1 mutation (25 available)
Baxtm1Sjk mutation (1 available); any Bax mutation (24 available)
Baxtm2Sjk mutation (1 available); any Bax mutation (24 available)
Bcl2l1tm1.1Mam mutation (0 available); any Bcl2l1 mutation (104 available)
Tg(MMTV-cre)#Mam mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:141545 )
N
• unlike in Bcl2l1tm1.1Mam/Bcl2l1tm1.1Mam Tg(MMTV-cre)Mam mice or Bnip3ltm1Ney homozygotes, spleen size, red blood cell numbers and reticulocytes clear of mitochondria are normal




Genotype
MGI:3843604
cn3
Allelic
Composition		 Bcl2l1tm1.1Mam/Bcl2l1tm1.1Mam
Tg(Ins2-cre)25Mgn/0
Tg(RIP1-Tag)2Dh/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l1tm1.1Mam mutation (0 available); any Bcl2l1 mutation (104 available)
Tg(Ins2-cre)25Mgn mutation (2 available)
Tg(RIP1-Tag)2Dh mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased pancreas tumor incidence ( J:146436 )
• 13 week old mice have a mean of over 4 tumors with an average volume greater than 50 mm3
• there is a significantly higher proportion of encapsulated, non-invasive tumors in these mice compared to Tg(RIP1-Tag)2Dh transgenics (22.8% vs. 4.3%)

endocrine/exocrine glands
increased pancreas tumor incidence ( J:146436 )
• 13 week old mice have a mean of over 4 tumors with an average volume greater than 50 mm3
• there is a significantly higher proportion of encapsulated, non-invasive tumors in these mice compared to Tg(RIP1-Tag)2Dh transgenics (22.8% vs. 4.3%)

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
pancreatic carcinoma DOID:4905 OMIM:260350
 J:146436




Genotype
MGI:3586797
cn4
Allelic
Composition		 Bcl2l1tm1.1Mam/Bcl2l1tm1.1Mam
7630403G23RikTg(Th-cre)1Tmd/?
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
7630403G23RikTg(Th-cre)1Tmd mutation (1 available); any 7630403G23Rik mutation (3 available)
Bcl2l1tm1.1Mam mutation (0 available); any Bcl2l1 mutation (104 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased brain weight ( J:99848 )
• brain weight is 508 +/- 24 mg compared to 571 +/- 8 mg in controls
decreased substantia nigra size ( J:99848 )
• the number of cells is decreased by 25 - 30% and most of the cells lost are tyrosine hydroxylase expressing cells
abnormal locus ceruleus morphology ( J:99848 )
• the number of cells is decreased by 31% and by 27% at 1 and 8-12 months of age, respectively, and most of the cells lost are tyrosine hydroxylase expressing cells

growth/size/body
decreased body weight ( J:99848 )
• body weight is reduced by 18 - 30% compared to control mice lacking the cre transgene

behavior/neurological
abnormal motor capabilities/coordination/movement ( J:99848 )
• mutants are able to stay on an accelerating rotorod significantly longer and at higher velocities

homeostasis/metabolism
decreased dopamine level ( J:99848 )
• striatal dopamine and dopamine metabolite levels are significantly reduced compared to controls




Genotype
MGI:3843606
cx5
Allelic
Composition		 Bcl2l1tm1.1Mam/Bcl2l1tm1.1Mam
Tg(RIP1-Tag)2Dh/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l1tm1.1Mam mutation (0 available); any Bcl2l1 mutation (104 available)
Tg(RIP1-Tag)2Dh mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased pancreas tumor incidence ( J:146436 )
• 13 week old mice have a mean of 7 tumors with an average volume greater than 40 mm3
• there is a significantly lower proportion of encapsulated, non-invasive tumors in these mice compared to Tg(RIP1-Tag)2Dh transgenics where cre-mediated recombination of Bcl2l1 occurs in pancreatic beta cells

endocrine/exocrine glands
increased pancreas tumor incidence ( J:146436 )
• 13 week old mice have a mean of 7 tumors with an average volume greater than 40 mm3
• there is a significantly lower proportion of encapsulated, non-invasive tumors in these mice compared to Tg(RIP1-Tag)2Dh transgenics where cre-mediated recombination of Bcl2l1 occurs in pancreatic beta cells

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
pancreatic carcinoma DOID:4905 OMIM:260350
 J:146436




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory