Analysis Tools|
Allele Symbol Allele Name Allele ID |
Bdnftm3Jae targeted mutation 3, Rudolf Jaenisch MGI:2176750 |
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| Summary |
9 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• locomotor activity, anxiety, and novel object recognition responses in animals receiving injections of a lentivirus-cre (LV-cre) in the prelimbic cortex are similar to controls
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• animals receiving injections of a LV-cre in the prelimbic cortex display normal acquisition and expression of newly acquired fear, but when retested for fear to the cue (tone), show significantly decreased freezing responses relative to controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• locomotor function, baseline startle response, pain sensitivity and prepulse inhibition are similar to controls
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• mice show robust attenuation of freezing when presented with the conditioned stimulus (tone) when tested for expression of previously learned fear
• mice show deficits in short- and long-term learning and memory to the conditioned cue, but display normal rate of extinction of conditioned fear
• 7,8-Dihydroxyflavone treatment rescues this impairment in cued fear conditioning
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• life span is shorter than in Mecp2 single homozygous mice
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• at P30 the firing rate of layer 5 pyramidal neurons of the somatosensory cortex is reduced compared to controls
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Rett syndrome | DOID:1206 |
OMIM:312750 OMIM:613454 |
J:106973 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• life span is shorter than in Mecp2 single hemizygous mice but longer than in mutant mice homozygous for the Bdnf allele
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• food intake is 74% higher than in controls
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• display increased inter-male aggression
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• mutants by 4 weeks of age become agitated and active and appear stressed when handled
• mutants continue to appear agitated after the habituation period in a novel cage, with a 40% reduction in activity after an hour of habituation compared to 72% reduction in controls
• in a light/dark exploration test, mutants take 3.6 times longer to make the first transition from the dark to the light compartment, they spend half as much time in the light zone compared with controls and only make 35% the number of dark-to-light zone transitions compared to controls
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• hindlimb clasping
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• hyperactive when stressed
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• increased body weight is seen at 8 weeks of age and by 30 weeks, males and females are 80 and 150% heavier than controls, respectively
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• 10% increase in naso-anal length compared with controls
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• abnormal starvation response in mutants as indicated by continued elevation of leptin, increased reduction in glucose levels, and attenuated NPY levels compared to controls after 48 hours of fasting
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• glucose levels are 70% higher than in controls
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• serum insulin levels are elevated 6-fold in obese mutants but normal in younger lean mutants
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• serum leptin levels are elevated 15-fold in obese mutants but normal in younger lean mutants
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• cholesterol levels are increased by 54% compared to controls
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• sterility in obese females but not younger lean females, indicating that sterility is secondary to the effect of obesity
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• decreased size of CA2 neurons
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• decreased size of the olfactory glomeruli
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• an increased number of stimulations are required to initiate kindling behavior, however once initiated progression through subsequent classes of kindling is the same as in wild-type mice and no increase in the current required to induce the initial electrographic seizure is seen
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• an increased number of stimulations are required to initiate kindling behavior, however once initiated progression through subsequent classes of kindling is the same as in wild-type mice and no increase in the current required to induce the initial electrographic seizure is seen
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• no response is seen to the antidepressant desipramine in mutants when doxycycline treatment is stopped at 3 months of age
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• contextual learning is impaired in mutants when doxycycline treatment is stopped at 3 months of age compared to mutant littermates maintained on doxycycline
• contextual learning is virtually absent in mutants when no doxycycline treatment is given throughout development
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• cued learning is normal in mutants when doxycycline treatment is stopped at 3 months of age but impaired when no doxycycline treatment is given throughout development
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• mutants bred without doxycycline treatment are hyperactive compared to mutants bred with doxycycline treatment
• hyperactivity is not seen when doxycycline treatment is stopped at 3 months of a
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• long term potentiation is impaired requiring a greater amplitude stimulus to evoke any response in mutants when doxycycline treatment is stopped at 3 months of age compared to mutant littermates maintained on doxycycline
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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