Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tg(Camk2a-cre)159Kln transgene insertion 159, Rudiger Klein MGI:2176753 |
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| Summary |
7 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice showed no overt behavioral abnormalities
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| N |
• normal hippocampal architecture
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• reduced early LTP but no significant defects of basal synaptic transmission parameters or NMDA receptor component
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in the light-dark box paradigm, mutant mice spend significantly more time in the lit compartment, display a decresead latency to enter the lit compartment, and show a signicantly higher number of entries into the lit compartment than control mice; however, no significant differences in the number of entries into the dark compartment are observed
• in the elevated plus maze test, mutant mice display significantly fewer head-dips in the protected arms as a percentage of total head dips, and an increase in the percentage of entries into the open arms; however, no significant differences in the number of entries into the closed arms are observed
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• mutant mice display increased locomotor activity in the open-field paradigm
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• although basal plasma corticosterone levels are normal, mutant mice display significantly higher plasma corticosterone levels at 30 and 90 min after a 5-min restraint stress relative to similarly-stressed control mice
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• although basal plasma ACTH levels are normal, mutant mice display significantly higher plasma ACTH levels at 30 and 90 min after a 5-min restraint stress relative to similarly-stressed control mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• basal synaptic transmission is normal but synaptic strengthening is impaired as evidenced by abnormal long term potentiation
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• there is a reduced induction rate of LTP in hippocampal slices
• induction (measured as a signal 20% above baseline) only occurs 37.0% of the time after burst stimulation compared to 70% in controls
• similar results are observed after tetanus application
• impairment also occurs after long-lasting LTP (L-LTP) that is tested by repeated theta burst
• L-LTP induction rate is 14.2% compared to 62.5% and does not improve with increased stimulus strength
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• a certain degree of task-specific long-term memory appears to be present but mutants show increasingly impaired learning behavior or inappropriate coping response when facing complex and/or stressful learning paradigms such as in contextual fear conditioning, two-way avoidance, radial maze and water maze learning
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• in avoidance learning, mutants first react normally to the new environment but fall into a persisting maladaptive locomotor activity
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• in the contextual fear conditioning, mutants fail to develop an appropriate freezing response after 30 min but show correct freezing after 24 hours yet not following exposure to tone
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• mutants show impaired spatial learning in the Morris water maze test and partial impairment in the eight-arm radial maze
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• mutants exhibit persistent thigmotaxis in the water maze
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• the number of myelinated axons in the CA1 region of the hippocampus is reduced by 23%
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• reduction in LTP at CA1 hippocampal synapses
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 2 month old mice show increased immobility in the forced swim test and in the tail suspension test
• mice treated with imipramine, a tricyclic antidepressant, show increased mobility in the forced swim test and the tail suspension test
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• mice exhibit lower preference to 1% sucrose solution than controls, indicating anhedonia
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• mice perform better on the rotarod most likely due to smaller body size
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• a decrease in proliferating cells is seen in the hippocampal dentate gyrus, indicating a decrease in postnatal neurogenesis
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• mild decrease in body weight during postnatal life, however by 4 months of age, weight is similar to controls
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• a decrease in proliferating cells is seen in the hippocampal dentate gyrus, indicating a decrease in postnatal neurogenesis
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| melancholic depression | DOID:1595 |
OMIM:608516 |
J:224698 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit normal behavior
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| N |
• the hippocampus and neurons within the hippocampus are normal
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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