All Phenotypes Tg(Camk2a-cre)93Kln MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Mecp2^tm1Jae/Y Tg(Camk2a-cre)93Kln/0	involves: 129S4/SvJae * BALB/c * C57BL/6 * CBA/J	MGI:3624685
cn2	Bdnf^tm3Jae/Bdnf^tm3Jae Mecp2^tm1.1Jae/Y Tg(Camk2a-cre)93Kln/0	involves: 129S4/SvJae * C57BL/6 * CBA/J	MGI:5306255
cn3	Bdnf^tm3Jae/Bdnf⁺ Mecp2^tm1.1Jae/Y Tg(Camk2a-cre)93Kln/0	involves: 129S4/SvJae * C57BL/6 * CBA/J	MGI:5306256
cn4	Col1a1^{tm8(CAG-BDNF)Jae}/Col1a1⁺ Mecp2^tm1.1Jae/Y Tg(Camk2a-cre)93Kln/0	involves: 129S4/SvJae * C57BL/6 * CBA/J	MGI:5306257
cn5	Bdnf^tm3Jae/Bdnf^tm3Jae Tg(Camk2a-cre)93Kln/0	involves: 129S4/SvJae * CBA/J	MGI:2176756

Allelic Composition	Mecp2^tm1Jae/Y Tg(Camk2a-cre)93Kln/0
Genetic Background	involves: 129S4/SvJae * BALB/c * C57BL/6 * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2^tm1Jae mutation (2 available); any Mecp2 mutation (41 available)
Tg(Camk2a-cre)93Kln mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

ataxia ( J:67909 )

• mutants appear healthy for up to 3 months when they begin to exhibit an ataxic gait

decreased locomotor activity ( J:67909 )

• mutants appear healthy for up to 3 months when they begin to show reduced nocturnal activity

growth/size/body

increased susceptibility to age related obesity ( J:67909 )

• 7 of 11 become overweight and obese at 10 weeks of age or older

• mutants appear healthy for up to 3 months when they begin to gain weight

nervous system

decreased brain weight ( J:67909 )

abnormal hippocampus CA2 region morphology ( J:67909 )

• neurons in the CA2 region are 15-25% smaller than in controls at 7.5 months of age

abnormal neuron morphology ( J:67909 )

• exhibit smaller neuronal bodies in the cortex and hippocampus but not in the cerebellum

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Rett syndrome		DOID:1206	OMIM:312750 OMIM:613454	J:67909

Allelic Composition	Bdnf^tm3Jae/Bdnf^tm3Jae Mecp2^tm1.1Jae/Y Tg(Camk2a-cre)93Kln/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnf^tm3Jae mutation (2 available); any Bdnf mutation (42 available)
Mecp2^tm1.1Jae mutation (2 available); any Mecp2 mutation (41 available)
Tg(Camk2a-cre)93Kln mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:106973 )

• life span is shorter than in Mecp2 single homozygous mice

behavior/neurological

lethargy ( J:106973 )

• dramatic reduction in wheel running activity at 4 weeks of age

nervous system

abnormal action potential ( J:106973 )

• at P30 the firing rate of layer 5 pyramidal neurons of the somatosensory cortex is reduced compared to controls

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Rett syndrome		DOID:1206	OMIM:312750 OMIM:613454	J:106973

Allelic Composition	Bdnf^tm3Jae/Bdnf⁺ Mecp2^tm1.1Jae/Y Tg(Camk2a-cre)93Kln/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * CBA/J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:106973 )

• life span is shorter than in Mecp2 single hemizygous mice but longer than in mutant mice homozygous for the Bdnf allele

Allelic Composition	Col1a1^{tm8(CAG-BDNF)Jae}/Col1a1⁺ Mecp2^tm1.1Jae/Y Tg(Camk2a-cre)93Kln/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1^{tm8(CAG-BDNF)Jae} mutation (0 available); any Col1a1 mutation (163 available)
Mecp2^tm1.1Jae mutation (2 available); any Mecp2 mutation (41 available)
Tg(Camk2a-cre)93Kln mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:106973 )

• life span is significantly longer than in Mecp2 single hemizygous mice

behavior/neurological

behavior/neurological phenotype ( J:106973 )

N	• overexpression of BDNF improves locomotor function compared to Mecp2 single hemizygous mice at 6 weeks of age

nervous system

decreased brain weight ( J:106973 )

• decreased compared to wild-type littermates but modestly increased compared to Mecp2 single hemizygous mice

abnormal action potential ( J:106973 )

• firing rate is increased compared to Mecp2 single hemizygous mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

polyphagia ( J:71969 )

• food intake is 74% higher than in controls

increased aggression towards male mice ( J:71969 )

• display increased inter-male aggression

increased anxiety-related response ( J:71969 )

• mutants by 4 weeks of age become agitated and active and appear stressed when handled

• mutants continue to appear agitated after the habituation period in a novel cage, with a 40% reduction in activity after an hour of habituation compared to 72% reduction in controls

• in a light/dark exploration test, mutants take 3.6 times longer to make the first transition from the dark to the light compartment, they spend half as much time in the light zone compared with controls and only make 35% the number of dark-to-light zone transitions compared to controls

limb grasping ( J:106973 )

• hindlimb clasping

hyperactivity ( J:71969 )

• hyperactive when stressed

growth/size/body

obese ( J:71969 )

• increased body weight is seen at 8 weeks of age and by 30 weeks, males and females are 80 and 150% heavier than controls, respectively

increased body length ( J:71969 )

• 10% increase in naso-anal length compared with controls

homeostasis/metabolism

abnormal homeostasis ( J:71969 )

• abnormal starvation response in mutants as indicated by continued elevation of leptin, increased reduction in glucose levels, and attenuated NPY levels compared to controls after 48 hours of fasting

increased circulating glucose level ( J:71969 )

• glucose levels are 70% higher than in controls

increased circulating insulin level ( J:71969 )

• serum insulin levels are elevated 6-fold in obese mutants but normal in younger lean mutants

increased circulating leptin level ( J:71969 )

• serum leptin levels are elevated 15-fold in obese mutants but normal in younger lean mutants

insulin resistance ( J:71969 )

increased cholesterol level ( J:71969 )

• cholesterol levels are increased by 54% compared to controls

reproductive system

reduced female fertility ( J:71969 )

• sterility in obese females but not younger lean females, indicating that sterility is secondary to the effect of obesity

nervous system

decreased brain weight ( J:106973 )

abnormal hippocampus CA2 region morphology ( J:106973 )

• decreased size of CA2 neurons

abnormal olfactory bulb morphology ( J:106973 )

• decreased size of the olfactory glomeruli

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