Phenotypes associated with this allele

• Allele Symbol: Lepr^tm1.1Rck
• Allele Name: targeted mutation 1.1, Jeffrey M Friedman
• Allele ID: MGI:2176775
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lepr^tm1.1Rck/Lepr^tm1.1Rck	involves: 129P2/OlaHsd	MGI:2176783
cn2	Lepr^tm1Rck/Lepr^tm1.1Rck Tg(Alb1-cre)1Rck/0	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:2176781
cn3	Lepr^tm1Rck/Lepr^tm1.1Rck Tg(Syn1-cre)671Jxm/0	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:2176782

Genotype
MGI:2176783

hm1

• Allelic Composition: Lepr^tm1.1Rck/Lepr^tm1.1Rck
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

obese ( J:72241 )

Genotype
MGI:2176781

cn2

• Allelic Composition: Lepr^tm1Rck/Lepr^tm1.1Rck; Tg(Alb1-cre)1Rck/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

normal phenotype

no abnormal phenotype detected ( J:72241 )

• normal body weight, normal amounts of adipose tissue, normal clinical chemistry and normal liver

Genotype
MGI:2176782

cn3

• Allelic Composition: Lepr^tm1Rck/Lepr^tm1.1Rck; Tg(Syn1-cre)671Jxm/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

adipose tissue

increased total body fat amount ( J:72241 )

growth/size/body

abnormal body composition ( J:72241 )

• increased adipose tissue mass and decreased lean tissue mass

increased body weight ( J:72241 )

• observed after 5 weeks of age

homeostasis/metabolism

hyperglycemia ( J:72241 )

• 2.3 fold greater plasma glucose levels in females compared to littermates; males normal

increased circulating insulin level ( J:72241 )

• hyperinsulinemia; 6 fold greater plasma insulin levels in males and 16.1 fold greater levels in females compared to littermates

increased circulating leptin level ( J:72241 )

• 5.8 fold greater in males and 8.3 fold greater in females compared to littermates

liver/biliary system

hepatic steatosis ( J:72241 )

• enlarged liver due to fatty deposits