Phenotypes associated with this allele

• Allele Symbol: Tg(Junb)1598Angl
• Allele Name: transgene insertion 1598, Peter Angel
• Allele ID: MGI:2176970
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Jun^tm1Wag/Jun^tm1Wag Tg(Junb)1598Angl/0	involves: 129S2/SvPas * C57BL/6	MGI:2662363

Genotype
MGI:2662363

cx1

• Allelic Composition: Jun^tm1Wag/Jun^tm1Wag; Tg(Junb)1598Angl/0
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:75359 )

• only a few mutant mice survive past weaning, with the oldest one reaching 7 months of age

perinatal lethality, incomplete penetrance ( J:75359 )

• although Mendelian ratios are recovered at E14.5-E18.5, only some viable mutant mice are born

postnatal lethality, incomplete penetrance ( J:75359 )

• only 4% of mutant mice reach weaning age

vision/eye

eyelids open at birth ( J:75359 )

• newborn mutant mice have open eyes but do not show any other overt defects

cardiovascular system

cardiovascular system phenotype ( J:75359 )

N • at E12.5, mutant fetuses exhibit normal formation of the aorta and pulmonary artery, indicating that development of the cardiac outflow tract is unaffected

liver/biliary system

liver/biliary system phenotype ( J:75359 )

N • at E15.5, mutant fetuses display normal liver architecture

cellular

abnormal cell proliferation ( J:75359 )

• similar to primary MEFs isolated from E12.5 Jun^tm1(Junb)Wag homozygotes, these mutant MEFs do not enter premature senescence and show increased proliferation relative to Jun^tm1Wag cells, but do not proliferate as fast as wild-type cells