All Phenotypes Msra<tm1Jmo> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Msra^tm1Jmo
targeted mutation 1, Jackob Moskovitz
MGI:2177027

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Msra^tm1Jmo/Msra^tm1Jmo	involves: 129X1/SvJ * C57BL/6	MGI:5490956
hm2	Msra^tm1Jmo/Msra^tm1Jmo	involves: 129X1/SvJ * C57BL/6J	MGI:3576570
cx3	Msra^tm1Jmo/Msra^tm1Jmo Msrb1^tm1.1Rlev/Msrb1^tm1.1Rlev	involves: 129X1/SvJ * BALB/cJ * C57BL/6	MGI:5490957

Allelic Composition	Msra^tm1Jmo/Msra^tm1Jmo
Genetic Background	involves: 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msra^tm1Jmo mutation (3 available); any Msra mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

growth/size/body region phenotype ( J:196824 )

N	• mice exhibit normal growth regardless of methionine content in diet

Allelic Composition	Msra^tm1Jmo/Msra^tm1Jmo
Genetic Background	involves: 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msra^tm1Jmo mutation (3 available); any Msra mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:72532 )

• 10% reduction in survival under hypoxia

• 40% reduction in survival under normotensive conditions

• all are dead by 23 months of age

cellular

oxidative stress ( J:72532 )

• sensitivity to oxidative stress increased in kidney, liver, and brain in particular

• measured as an increase in carbonylated protein

homeostasis/metabolism

abnormal enzyme/coenzyme level ( J:72532 )

• under conditions of hyperoxia thioredoxin reductase levels in the liver increase less than they do in controls (2X vs 3 X)

• thioredoxin reductase levels in the brain drop 40% under hyperoxia conditions whereas they are unaffected in controls

behavior/neurological

abnormal gait ( J:72532 )

• after 6 months of age, homozygous mice walk on the tips of their toes

Allelic Composition	Msra^tm1Jmo/Msra^tm1Jmo Msrb1^tm1.1Rlev/Msrb1^tm1.1Rlev
Genetic Background	involves: 129X1/SvJ * BALB/cJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msra^tm1Jmo mutation (3 available); any Msra mutation (36 available)
Msrb1^tm1.1Rlev mutation (1 available); any Msrb1 mutation (8 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:196824 )

• in mice fed a diet with 0.10% or 0.15% methionine unlike single homozygotes

• however, mice fed a diet with 0.45% methionine exhibit normal growth

postnatal growth retardation ( J:196824 )

• in mice fed a diet with 0.10% or 0.15% methionine unlike single homozygotes

• however, mice fed a diet with 0.45% methionine exhibit normal growth

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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