Phenotypes associated with this allele

• Allele Symbol: cir
• Allele Name: circling
• Allele ID: MGI:2177206
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	cir/cir	involves: C57BL/6J * ICR	MGI:3832330
hm2	cir/cir	involves: ICR	MGI:2663226
cx3	Tmie^sr/cir	involves: C57BL/6J * C57BL/How * ICR	MGI:3832331

Genotype
MGI:3832330

hm1

• Allelic Composition: cir/cir
• Genetic Background: involves: C57BL/6J * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal behavior ( J:144656 )

• in an open-field test, mice remain in the center longer than wild-type mice

impaired balance ( J:144656 )

• mice exhibit impaired balance on a stationary rod compared to wild-type mice

circling ( J:144656 )

• mice exhibit circling and an increased latency to start circling compared to wild-type mice or Tmie^sr homozygotes

Genotype
MGI:2663226

hm2

• Allelic Composition: cir/cir
• Genetic Background: involves: ICR

behavior/neurological

decreased grooming behavior ( J:73719 )

absent startle reflex ( J:73719 )

• circling mice show no acoustic startle responses to startle stimuli of 80 or 120 dB

impaired swimming ( J:73719 )

• all circling mice fail to orient themselves while swimming, spiral underwater, and are unable to keep their nose and tail above water

head shaking ( J:73719 )

• head shaking is first noticable at 7 days of age and increases over the next 3-4 days

decreased vertical activity ( J:73719 )

• circling mice display a reduced rearing score relative to wild-type mice (12.67 vs 56.17, respectively)

hyperactivity ( J:73719 )

• all mice are born normal but gradually become hyperactivite beginning at ~7 days of age

circling ( J:73719 )

• mice run in tight circles, esp. when disturbed or placed in strange surroundings, with no preference for any particular direction

pup cannibalization ( J:73719 )

♀ • female circling mice display cannibalism towards heterozygous offspring

hearing/vestibular/ear

abnormal inner ear morphology ( J:73719 )

• at 15 weeks, circling mice display morphological abnomalities of the inner ear

• in contrast, the saccule, utricle, semicircular canals, vestibular hair cells and Scarpa ganglion cells remain intact

abnormal Rosenthal canal morphology ( J:73719 )

• at 15 weeks, Rosenthal canal appears empty due to severe degeneration of the axons between the hair cells and the spiral ganglion cells

cochlear outer hair cell degeneration ( J:73719 )

• at 15 weeks, OHCs are completely lost

organ of Corti degeneration ( J:73719 )

• organ of Corti degeneration is noted at 100 days of age

• however, supporting cells and the stria vascularis remain intact

deafness ( J:73719 )

• circling mice are totally deaf, as shown by absence of acoustic startle responses at all frequencies tested

growth/size/body

decreased body weight ( J:73719 )

• at P7-P100, mutant mice weigh 20%-25% less than wild-type littermates

• however, both viability and fertility remain normal

nervous system

cochlear outer hair cell degeneration ( J:73719 )

• at 15 weeks, OHCs are completely lost

cochlear ganglion degeneration ( J:73719 )

• at 15 weeks, spiral ganglion cells are almost completely degenerated

Genotype
MGI:3832331

cx3

• Allelic Composition: Tmie^sr/cir
• Genetic Background: involves: C57BL/6J * C57BL/How * ICR

behavior/neurological

abnormal behavior ( J:144656 )

• in an open-field test, mice remain in the center longer than wild-type mice

impaired balance ( J:144656 )

• mice exhibit impaired balance on a stationary rod compared to wild-type mice

circling ( J:144656 )

• mice exhibit circling and an increased latency to start circling compared to wild-type mice or Tmie^sr homozygotes