All Phenotypes Wap<tm1(cre)Arge> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Wap^tm1(cre)Arge
targeted mutation 1, Argiris Efstratiadis
MGI:2177210

Summary

16 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Wap^tm1(cre)Arge/Wap^tm1(cre)Arge	involves: 129S1/Sv * C57BL/6J	MGI:3038955
cn2	Eef1a1^{tm1(Kras*)Arge}/Eef1a1⁺ Wap^tm1(cre)Arge/Wap⁺	involves: 129S1/Sv	MGI:3837707
cn3	Eef1a1^{tm1(Kras*)Arge}/Eef1a1⁺ Igf1r^tm2Arge/Igf1r^tm2Arge Wap^tm1(cre)Arge/Wap⁺	involves: 129S1/Sv	MGI:3837711
cn4	Actb^{tm1(PyVT)Arge}/Actb⁺ Wap^tm1(cre)Arge/Wap⁺	involves: 129S1/Sv	MGI:3032632
cn5	Eef1a1^{tm1(Kras*)Arge}/Eef1a1⁺ Igf1r^tm2Arge/Igf1r⁺ Wap^tm1(cre)Arge/Wap⁺	involves: 129S1/Sv	MGI:3837708
cn6	Brca1^tm2.1Cxd/Brca1^tm3.1Rjbr Trp53^tm3Tyj/Trp53⁺ Wap^tm1(cre)Arge/Wap⁺	involves: 129S1/Sv * 129S4/SvJae * 129S6/SvEvTac * C57BL/6	MGI:5494461
cn7	Brca1^tm2.1Cxd/Brca1^tm2Rjbr Trp53^tm3Tyj/Trp53⁺ Wap^tm1(cre)Arge/Wap⁺	involves: 129S1/Sv * 129S4/SvJae * 129S6/SvEvTac * C57BL/6	MGI:5494458
cn8	Brca1^tm2.1Cxd/Brca1^tm2.1Cxd Trp53^tm3Tyj/Trp53⁺ Wap^tm1(cre)Arge/Wap⁺	involves: 129S1/Sv * 129S4/SvJae * 129S6/SvEvTac * C57BL/6	MGI:5494460
cn9	Brca1^tm2.1Cxd/Brca1^tm3.1Rjbr Wap^tm1(cre)Arge/Wap⁺	involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6	MGI:5494459
cn10	Brca2^tm2Arge/Brca2^tm2Arge Wap^tm1(cre)Arge/Wap^tm1(cre)Arge	involves: 129S1/Sv * C57BL/6	MGI:2177239
cn11	Brca1^tm1Thl/Brca1^tm1Thl Wap^tm1(cre)Arge/0	involves: 129S1/Sv * C57BL/6J	MGI:3805033
cn12	Bard1^tm1Thl/Bard1^tm2Thl Wap^tm1(cre)Arge/0	involves: 129S1/Sv * C57BL/6J	MGI:3805024
cn13	Brca1^tm1Arge/Brca1^tm1Thl Wap^tm1(cre)Arge/0	involves: 129S/SvEv * 129S1/Sv * C57BL/6J	MGI:3805032
cn14	Brca2^tm1Arge/Brca2^tm2Arge Wap^tm1(cre)Arge/Wap⁺	involves: 129S/SvEv * C57BL/6	MGI:2177237
cn15	Bard1^tm2Thl/Bard1^tm2Thl Brca1^tm1Thl/Brca1^tm1Thl Wap^tm1(cre)Arge/0	involves: 129/Sv * 129S1/Sv * C57BL/6J	MGI:3805035
cn16	Bard1^tm2Thl/Bard1^tm2Thl Wap^tm1(cre)Arge/0	involves: 129/Sv * 129S1/Sv * C57BL/6J	MGI:3805029

Allelic Composition	Wap^tm1(cre)Arge/Wap^tm1(cre)Arge
Genetic Background	involves: 129S1/Sv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wap^tm1(cre)Arge mutation (0 available); any Wap mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:70564 )

• no overt phenotype; females do not appear to have a defect in maternal milk production or quality

Allelic Composition	Eef1a1^{tm1(Kras*)Arge}/Eef1a1⁺ Wap^tm1(cre)Arge/Wap⁺
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eef1a1^{tm1(Kras*)Arge} mutation (0 available); any Eef1a1 mutation (60 available)
Wap^tm1(cre)Arge mutation (0 available); any Wap mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Histology and immunophenotyping of mammary carcinomas in Eef1a1^{tm1(Kras*)Arge}/Eef1a1⁺ Wap^tm1(cre)Arge/Wap⁺ mice

mortality/aging

decreased tumor-free survival time ( J:146290 )

• median tumor-free survival of lactating female mice is 9 days from the first parturition

neoplasm

increased mammary gland tumor incidence ( J:146290 )

• within 2 days to 2 months of first delivery, lactating females develop palpable multifocal, fully invasive tumors of the mammary gland unlike wild-type mice

• median tumor-free survival of lactating female mice is 9 days from the first parturition

• lactating female mice develop adenocarcinomas, and pale, squamous, and spindle cell carcinomas

• however, treatment with picropodophyllin decreases tumor mass

increased mammary adenocarcinoma incidence ( J:146290 )

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:146290 )

• within 2 days to 2 months of first delivery, lactating females develop palpable multifocal, fully invasive tumors of the mammary gland unlike wild-type mice

• median tumor-free survival of lactating female mice is 9 days from the first parturition

• lactating female mice develop adenocarcinomas, and pale, squamous, and spindle cell carcinomas

• however, treatment with picropodophyllin decreases tumor mass

increased mammary adenocarcinoma incidence ( J:146290 )

integument

increased mammary gland tumor incidence ( J:146290 )

• within 2 days to 2 months of first delivery, lactating females develop palpable multifocal, fully invasive tumors of the mammary gland unlike wild-type mice

• median tumor-free survival of lactating female mice is 9 days from the first parturition

• lactating female mice develop adenocarcinomas, and pale, squamous, and spindle cell carcinomas

• however, treatment with picropodophyllin decreases tumor mass

increased mammary adenocarcinoma incidence ( J:146290 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:146290

Allelic Composition	Eef1a1^{tm1(Kras*)Arge}/Eef1a1⁺ Igf1r^tm2Arge/Igf1r^tm2Arge Wap^tm1(cre)Arge/Wap⁺
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eef1a1^{tm1(Kras*)Arge} mutation (0 available); any Eef1a1 mutation (60 available)
Igf1r^tm2Arge mutation (1 available); any Igf1r mutation (88 available)
Wap^tm1(cre)Arge mutation (0 available); any Wap mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased tumor-free survival time ( J:146290 )

• median tumor free survival of lactating females is 101 days from the first parturition

neoplasm

increased mammary gland tumor incidence ( J:146290 )

• female mice develop mammary gland tumors after 3 pregnancies with an 11-fold increase in latency compared to in Eef1a1^{tm1(Kras*)Arge} Wap^tm1(cre)Arge heterozygotes

• median tumor free survival of lactating females is 101 days from the first parturition

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:146290 )

• female mice develop mammary gland tumors after 3 pregnancies with an 11-fold increase in latency compared to in Eef1a1^{tm1(Kras*)Arge} Wap^tm1(cre)Arge heterozygotes

• median tumor free survival of lactating females is 101 days from the first parturition

integument

increased mammary gland tumor incidence ( J:146290 )

• female mice develop mammary gland tumors after 3 pregnancies with an 11-fold increase in latency compared to in Eef1a1^{tm1(Kras*)Arge} Wap^tm1(cre)Arge heterozygotes

• median tumor free survival of lactating females is 101 days from the first parturition

Allelic Composition	Actb^{tm1(PyVT)Arge}/Actb⁺ Wap^tm1(cre)Arge/Wap⁺
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Actb^{tm1(PyVT)Arge} mutation (0 available); any Actb mutation (53 available)
Wap^tm1(cre)Arge mutation (0 available); any Wap mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:87544 )

• premature death

neoplasm

increased mammary adenocarcinoma incidence ( J:87544 )

cardiovascular system

decreased cardiac muscle contractility ( J:87544 )

• exhibited by 70% of females (mostly virgins, indicating that this phenotype is associated with cre-independent excision of the floxed neomycin cassette)

muscle

decreased cardiac muscle contractility ( J:87544 )

• exhibited by 70% of females (mostly virgins, indicating that this phenotype is associated with cre-independent excision of the floxed neomycin cassette)

integument

increased mammary adenocarcinoma incidence ( J:87544 )

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:87544 )

Allelic Composition	Eef1a1^{tm1(Kras*)Arge}/Eef1a1⁺ Igf1r^tm2Arge/Igf1r⁺ Wap^tm1(cre)Arge/Wap⁺
Genetic Background	involves: 129S1/Sv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased tumor-free survival time ( J:146290 )

• median tumor free survival of lactating females is 43 days from the first parturition

neoplasm

increased mammary gland tumor incidence ( J:146290 )

• female mice develop mammary gland tumors with a 5-fold increase in latency compared to in Eef1a1^{tm1(Kras*)Arge} Wap^tm1(cre)Arge heterozygotes

• median tumor free survival of lactating females is 43 days from the first parturition

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:146290 )

• female mice develop mammary gland tumors with a 5-fold increase in latency compared to in Eef1a1^{tm1(Kras*)Arge} Wap^tm1(cre)Arge heterozygotes

• median tumor free survival of lactating females is 43 days from the first parturition

integument

increased mammary gland tumor incidence ( J:146290 )

• female mice develop mammary gland tumors with a 5-fold increase in latency compared to in Eef1a1^{tm1(Kras*)Arge} Wap^tm1(cre)Arge heterozygotes

• median tumor free survival of lactating females is 43 days from the first parturition

Allelic Composition	Brca1^tm2.1Cxd/Brca1^tm3.1Rjbr Trp53^tm3Tyj/Trp53⁺ Wap^tm1(cre)Arge/Wap⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1^tm2.1Cxd mutation (1 available); any Brca1 mutation (114 available)
Brca1^tm3.1Rjbr mutation (1 available); any Brca1 mutation (114 available)
Trp53^tm3Tyj mutation (3 available); any Trp53 mutation (240 available)
Wap^tm1(cre)Arge mutation (0 available); any Wap mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased tumor latency ( J:177853 )

• compared with Brca1^tm2.1Cxd/Brca1^tm2.1Cxd Trp53^tm3Tyj/Trp53^tm3Tyj Wap^tm1(cre)Arge/Wap^tm1(cre)Arge

Allelic Composition	Brca1^tm2.1Cxd/Brca1^tm2Rjbr Trp53^tm3Tyj/Trp53⁺ Wap^tm1(cre)Arge/Wap⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1^tm2.1Cxd mutation (1 available); any Brca1 mutation (114 available)
Brca1^tm2Rjbr mutation (1 available); any Brca1 mutation (114 available)
Trp53^tm3Tyj mutation (3 available); any Trp53 mutation (240 available)
Wap^tm1(cre)Arge mutation (0 available); any Wap mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased tumor latency ( J:177853 )

• 308 days compared with 380 days in Trp53^tm3Tyj Wap^tm1(cre)Arge double heterozygotes

• however, latency is similar to in Brca1^tm2.1Cxd/Brca1^tm2.1Cxd Trp53^tm3Tyj/Trp53⁺ Wap^tm1(cre)Arge/Wap⁺

Allelic Composition	Brca1^tm2.1Cxd/Brca1^tm2.1Cxd Trp53^tm3Tyj/Trp53⁺ Wap^tm1(cre)Arge/Wap⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1^tm2.1Cxd mutation (1 available); any Brca1 mutation (114 available)
Trp53^tm3Tyj mutation (3 available); any Trp53 mutation (240 available)
Wap^tm1(cre)Arge mutation (0 available); any Wap mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased tumor latency ( J:177853 )

• 308 days compared with 380 days in Trp53^tm3Tyj Wap^tm1(cre)Arge double heterozygotes

Allelic Composition	Brca1^tm2.1Cxd/Brca1^tm3.1Rjbr Wap^tm1(cre)Arge/Wap⁺
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1^tm2.1Cxd mutation (1 available); any Brca1 mutation (114 available)
Brca1^tm3.1Rjbr mutation (1 available); any Brca1 mutation (114 available)
Wap^tm1(cre)Arge mutation (0 available); any Wap mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:177853 )

N	• unlike in mice with Brca1^tm2.1Cxd/Brca1^tm2.1Cxd Wap^tm1(cre)Arge/Wap⁺, mice remain tumor free over a 24-month observation period

Allelic Composition	Brca2^tm2Arge/Brca2^tm2Arge Wap^tm1(cre)Arge/Wap^tm1(cre)Arge
Genetic Background	involves: 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca2^tm2Arge mutation (0 available); any Brca2 mutation (132 available)
Wap^tm1(cre)Arge mutation (0 available); any Wap mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:70564 )

• mammary tumors occur after long latency of at least 13 months of age

• T₅₀ for tumor-free survival is approximately 17 months of age

• at the end of the 20 month observation period, 20 of 26 animals developed mammary tumors; control animals developed none

• tumor pathology corresponded to two characteristic types, solid carcinoma and adenoacanthoma, with a mixture of the two types frequently appearing in the same tumor mass

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:70564 )

• mammary tumors occur after long latency of at least 13 months of age

• T₅₀ for tumor-free survival is approximately 17 months of age

• at the end of the 20 month observation period, 20 of 26 animals developed mammary tumors; control animals developed none

• tumor pathology corresponded to two characteristic types, solid carcinoma and adenoacanthoma, with a mixture of the two types frequently appearing in the same tumor mass

integument

increased mammary adenocarcinoma incidence ( J:70564 )

• mammary tumors occur after long latency of at least 13 months of age

• T₅₀ for tumor-free survival is approximately 17 months of age

• at the end of the 20 month observation period, 20 of 26 animals developed mammary tumors; control animals developed none

• tumor pathology corresponded to two characteristic types, solid carcinoma and adenoacanthoma, with a mixture of the two types frequently appearing in the same tumor mass

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:70564

Allelic Composition	Brca1^tm1Thl/Brca1^tm1Thl Wap^tm1(cre)Arge/0
Genetic Background	involves: 129S1/Sv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1^tm1Thl mutation (1 available); any Brca1 mutation (114 available)
Wap^tm1(cre)Arge mutation (0 available); any Wap mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:134977 )

• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 512 days

• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive

• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate

• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes

• neoplasms often invade in a broad front and push towards the underlying pectoral muscle

• a small minority of tumors have sqaumous characteristics

• pre-cancerous neoplasia are also evident throughout the mammary gland

integument

increased mammary adenocarcinoma incidence ( J:134977 )

• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 512 days

• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive

• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate

• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes

• neoplasms often invade in a broad front and push towards the underlying pectoral muscle

• a small minority of tumors have sqaumous characteristics

• pre-cancerous neoplasia are also evident throughout the mammary gland

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:134977 )

• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 512 days

• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive

• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate

• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes

• neoplasms often invade in a broad front and push towards the underlying pectoral muscle

• a small minority of tumors have sqaumous characteristics

• pre-cancerous neoplasia are also evident throughout the mammary gland

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:134977

Allelic Composition	Bard1^tm1Thl/Bard1^tm2Thl Wap^tm1(cre)Arge/0
Genetic Background	involves: 129S1/Sv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bard1^tm1Thl mutation (0 available); any Bard1 mutation (55 available)
Bard1^tm2Thl mutation (0 available); any Bard1 mutation (55 available)
Wap^tm1(cre)Arge mutation (0 available); any Wap mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:134977 )

• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 465 days

• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive

• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate

• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes

• neoplasms often invade in a broad front and push towards the underlying pectoral muscle

• a small minority of tumors have sqaumous characteristics

• pre-cancerous neoplasia are also evident throughout the mammary gland

integument

increased mammary adenocarcinoma incidence ( J:134977 )

• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 465 days

• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive

• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate

• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes

• neoplasms often invade in a broad front and push towards the underlying pectoral muscle

• a small minority of tumors have sqaumous characteristics

• pre-cancerous neoplasia are also evident throughout the mammary gland

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:134977 )

• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 465 days

• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive

• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate

• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes

• neoplasms often invade in a broad front and push towards the underlying pectoral muscle

• a small minority of tumors have sqaumous characteristics

• pre-cancerous neoplasia are also evident throughout the mammary gland

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:134977

Allelic Composition	Brca1^tm1Arge/Brca1^tm1Thl Wap^tm1(cre)Arge/0
Genetic Background	involves: 129S/SvEv * 129S1/Sv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1^tm1Arge mutation (0 available); any Brca1 mutation (114 available)
Brca1^tm1Thl mutation (1 available); any Brca1 mutation (114 available)
Wap^tm1(cre)Arge mutation (0 available); any Wap mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:134977 )

• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 512 days

• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive

• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate

• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes

• neoplasms often invade in a broad front and push towards the underlying pectoral muscle

• a small minority of tumors have sqaumous characteristics

• pre-cancerous neoplasia are also evident throughout the mammary gland

integument

increased mammary adenocarcinoma incidence ( J:134977 )

• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 512 days

• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive

• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate

• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes

• neoplasms often invade in a broad front and push towards the underlying pectoral muscle

• a small minority of tumors have sqaumous characteristics

• pre-cancerous neoplasia are also evident throughout the mammary gland

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:134977 )

• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 512 days

• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive

• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate

• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes

• neoplasms often invade in a broad front and push towards the underlying pectoral muscle

• a small minority of tumors have sqaumous characteristics

• pre-cancerous neoplasia are also evident throughout the mammary gland

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:134977

Allelic Composition	Brca2^tm1Arge/Brca2^tm2Arge Wap^tm1(cre)Arge/Wap⁺
Genetic Background	involves: 129S/SvEv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca2^tm1Arge mutation (0 available); any Brca2 mutation (132 available)
Brca2^tm2Arge mutation (0 available); any Brca2 mutation (132 available)
Wap^tm1(cre)Arge mutation (0 available); any Wap mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:70564 )

• mammary tumors occur after long latency of at least 13 months of age

• T₅₀ for tumor-free survival is approximately 17 months of age

• at the end of the 20 month observation period, 20 of 26 animals developed mammary tumors; control animals developed none

• tumor pathology corresponded to two characteristic types, solid carcinoma and adenoacanthoma, with a mixture of the two types frequently appearing in the same tumor mass

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:70564 )

• mammary tumors occur after long latency of at least 13 months of age

• T₅₀ for tumor-free survival is approximately 17 months of age

• at the end of the 20 month observation period, 20 of 26 animals developed mammary tumors; control animals developed none

• tumor pathology corresponded to two characteristic types, solid carcinoma and adenoacanthoma, with a mixture of the two types frequently appearing in the same tumor mass

integument

increased mammary adenocarcinoma incidence ( J:70564 )

• mammary tumors occur after long latency of at least 13 months of age

• T₅₀ for tumor-free survival is approximately 17 months of age

• at the end of the 20 month observation period, 20 of 26 animals developed mammary tumors; control animals developed none

• tumor pathology corresponded to two characteristic types, solid carcinoma and adenoacanthoma, with a mixture of the two types frequently appearing in the same tumor mass

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:70564

Allelic Composition	Bard1^tm2Thl/Bard1^tm2Thl Brca1^tm1Thl/Brca1^tm1Thl Wap^tm1(cre)Arge/0
Genetic Background	involves: 129/Sv * 129S1/Sv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bard1^tm2Thl mutation (0 available); any Bard1 mutation (55 available)
Brca1^tm1Thl mutation (1 available); any Brca1 mutation (114 available)
Wap^tm1(cre)Arge mutation (0 available); any Wap mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:134977 )

• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 473 days

• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive

• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate

• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes

• neoplasms often invade in a broad front and push towards the underlying pectoral muscle

• a small minority of tumors have sqaumous characteristics

• pre-cancerous neoplasia are also evident throughout the mammary gland

integument

increased mammary adenocarcinoma incidence ( J:134977 )

• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 473 days

• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive

• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate

• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes

• neoplasms often invade in a broad front and push towards the underlying pectoral muscle

• a small minority of tumors have sqaumous characteristics

• pre-cancerous neoplasia are also evident throughout the mammary gland

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:134977 )

• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 473 days

• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive

• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate

• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes

• neoplasms often invade in a broad front and push towards the underlying pectoral muscle

• a small minority of tumors have sqaumous characteristics

• pre-cancerous neoplasia are also evident throughout the mammary gland

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:134977

Allelic Composition	Bard1^tm2Thl/Bard1^tm2Thl Wap^tm1(cre)Arge/0
Genetic Background	involves: 129/Sv * 129S1/Sv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bard1^tm2Thl mutation (0 available); any Bard1 mutation (55 available)
Wap^tm1(cre)Arge mutation (0 available); any Wap mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:134977 )

• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 465 days

• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive

• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate

• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes

• neoplasms often invade in a broad front and push towards the underlying pectoral muscle

• a small minority of tumors have sqaumous characteristics

• pre-cancerous neoplasia are also evident throughout the mammary gland

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:134977 )

• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 465 days

• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive

• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate

• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes

• neoplasms often invade in a broad front and push towards the underlying pectoral muscle

• a small minority of tumors have sqaumous characteristics

• pre-cancerous neoplasia are also evident throughout the mammary gland

integument

increased mammary adenocarcinoma incidence ( J:134977 )

• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 465 days

• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive

• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate

• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes

• neoplasms often invade in a broad front and push towards the underlying pectoral muscle

• a small minority of tumors have sqaumous characteristics

• pre-cancerous neoplasia are also evident throughout the mammary gland

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:134977

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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