Phenotypes associated with this allele

• Allele Symbol: Brca2^tm1Brd
• Allele Name: targeted mutation 1, Allan Bradley
• Allele ID: MGI:2177233
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Brca2^tm1Brd/Brca2^tm1Brd	involves: 129S7/SvEvBrd	MGI:2177234
ht2	Brca2^tm1Brd/Brca2^+	involves: 129S7/SvEvBrd	MGI:2177235
ht3	Brca2^tm2.1Sks/Brca2^tm1Brd	B6.Cg-Brca2^tm1Brd Brca2^tm2.1Sks	MGI:7279298
ht4	Brca2^tm1Brd/Brca2^tm1.1Sks	involves: 129 * 129S7/SvEvBrd * C57BL/6J * FVB/N	MGI:5438031

Genotype
MGI:2177234

hm1

• Allelic Composition: Brca2^tm1Brd/Brca2^tm1Brd
• Genetic Background: involves: 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:39764 )

embryo

abnormal developmental patterning ( J:39764 )

abnormal embryonic tissue morphology ( J:39764 )

abnormal extraembryonic tissue morphology ( J:39764 )

Genotype
MGI:2177235

ht2

• Allelic Composition: Brca2^tm1Brd/Brca2⁺
• Genetic Background: involves: 129S7/SvEvBrd

normal phenotype

no abnormal phenotype detected ( J:39764 )

Genotype
MGI:7279298

ht3

• Allelic Composition: Brca2^tm2.1Sks/Brca2^tm1Brd
• Genetic Background: B6.Cg-Brca2^tm1Brd Brca2^tm2.1Sks

embryo

embryo phenotype ( J:323630 )

N • no obvious histological anomalies or morphological defects other than small size at stages E16.5 and E18.5

decreased embryo size ( J:323630 )

• at stages E16.5 and E18.5

mortality/aging

increased mortality induced by ionizing radiation ( J:323630 )

• significantly reduced survival rate after gamma-ray exposure

premature death ( J:323630 )

• significantly reduced lifespan

prenatal lethality, incomplete penetrance ( J:323630 )

• reduced number of embryos at stage E16.5

• mice born at below expected Mendelian ratio

• normal Mendelian ration of genotypes at stages E9.5, E13.5 and E14.5

growth/size/body

growth/size/body region phenotype ( J:323630 )

N • normal histological and morphological appearance

decreased embryo size ( J:323630 )

• at stages E16.5 and E18.5

decreased birth body size ( J:323630 )

decreased birth weight ( J:323630 )

decreased body size ( J:323630 )

• persisting through weaning and adulthood

decreased body weight ( J:323630 )

• persisting through weaning and adulthood

endocrine/exocrine glands

abnormal branching of the mammary ductal tree ( J:323630 )

♀ • significantly reduced at age 4-6 weeks

decreased mammary duct terminal end bud number ( J:323630 )

♀ • significantly reduced at age 4-6 weeks

homeostasis/metabolism

increased mortality induced by ionizing radiation ( J:323630 )

• significantly reduced survival rate after gamma-ray exposure

integument

abnormal branching of the mammary ductal tree ( J:323630 )

♀ • significantly reduced at age 4-6 weeks

decreased mammary duct terminal end bud number ( J:323630 )

♀ • significantly reduced at age 4-6 weeks

behavior/neurological

behavior/neurological phenotype ( J:323630 )

♀N • normal nursing

neoplasm

neoplasm ( J:323630 )

N • normal tumor incidence in aged mice

reproductive system

reproductive system phenotype ( J:323630 )

N • fertile and producing normal litter size

Genotype
MGI:5438031

ht4

• Allelic Composition: Brca2^tm1Brd/Brca2^tm1.1Sks
• Genetic Background: involves: 129 * 129S7/SvEvBrd * C57BL/6J * FVB/N

reproductive system

reproductive system phenotype ( J:187434 )

N • mice exhibit normal gonad sizes, fecundity and fertility