mortality/aging
embryo
Allele Symbol Allele Name Allele ID |
Brca2tm1Brd targeted mutation 1, Allan Bradley MGI:2177233 |
||||||||||||||||||||
Summary |
4 genotypes
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• no obvious histological anomalies or morphological defects other than small size at stages E16.5 and E18.5
|
• at stages E16.5 and E18.5
|
• significantly reduced survival rate after gamma-ray exposure
|
• significantly reduced lifespan
|
• mice born at below expected Mendelian ratio
• reduced number of embryos at stage E16.5
• normal Mendelian ration of genotypes at stages E9.5, E13.5 and E14.5
|
N |
• normal histological and morphological appearance
|
• at stages E16.5 and E18.5
|
• persisting through weaning and adulthood
|
• persisting through weaning and adulthood
|
• significantly reduced at age 4-6 weeks
|
• significantly reduced at age 4-6 weeks
|
• significantly reduced survival rate after gamma-ray exposure
|
• significantly reduced at age 4-6 weeks
|
• significantly reduced at age 4-6 weeks
|
N |
• normal nursing
|
N |
• fertile and producing normal litter size
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• mice exhibit normal gonad sizes, fecundity and fertility
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 11/19/2024 MGI 6.24 |
|
|