All Phenotypes Erbb2<tm2Cbm> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Egr2^tm2(cre)Pch/Egr2⁺ Erbb2^tm1Cbm/Erbb2^tm2Cbm	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6	MGI:2177311
cn2	Egr2^tm2(cre)Pch/Egr2⁺ Erbb2^tm2Cbm/Erbb2^tm2Cbm	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6	MGI:5524263
cn3	Erbb2^tm1Cbm/Erbb2^tm2Cbm Myl2^tm1(cre)Krc/Myl2⁺	involves: 129P2/OlaHsd * 129S4/SvJae	MGI:3621567

Allelic Composition	Egr2^tm2(cre)Pch/Egr2⁺ Erbb2^tm1Cbm/Erbb2^tm2Cbm
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egr2^tm2(cre)Pch mutation (2 available); any Egr2 mutation (35 available)
Erbb2^tm1Cbm mutation (0 available); any Erbb2 mutation (59 available)
Erbb2^tm2Cbm mutation (0 available); any Erbb2 mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:75421 )

• 5 of 37 die within 6 months

behavior/neurological

abnormal locomotor activation ( J:75421 )

• difficulties in hindlimb movement

abnormal gait ( J:75421 )

• gait abnormalities

growth/size/body

cachexia ( J:75421 )

• display wasting associated with weight loss and premature death

limbs/digits/tail

kinked tail ( J:75421 )

• kinked or serpentine tails

nervous system

decreased Schwann cell number ( J:75421 )

• at P3.5, see a 10-fold reduction in ventral and a 5-fold reduction in dorsal roots, with this reduction still apparent at P15, however by 6 months of age, cell numbers are similar to those in controls, however myelin sheaths formed are thin

abnormal myelin sheath morphology ( J:75421 )

• reduction in thickness of the myelin sheath of sciatic nerves at P15 that persists at 6 and 14 months of age

• thin myelin is due to the presence of fewer wraps of myelin around the axon

abnormal dorsal spinal root morphology ( J:75421 )

• dorsal roots display a severe decrease of Schwann cells in all mutants at P3.5 and P15

abnormal sciatic nerve morphology ( J:75421 )

• sciatic nerves at P15 are translucent and thin

abnormal ventral spinal root morphology ( J:75421 )

• ventral roots display a severe decrease of Schwann cells in all mutants at P3.5 and P15

• about 20% loss of axons in the L5 ventral root

abnormal myelination ( J:75421 )

• hypomyelination in sciatic, sural, saphenous nerves, nerves innervating lower leg muscles, and the dorsal spinal roots and absent myelin in ventral spinal roots

• occasionally see large-caliber axons lacking myelin that are still surrounded by a Schwann cell basal lamina in the sciatic nerve

Allelic Composition	Egr2^tm2(cre)Pch/Egr2⁺ Erbb2^tm2Cbm/Erbb2^tm2Cbm
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egr2^tm2(cre)Pch mutation (2 available); any Egr2 mutation (35 available)
Erbb2^tm2Cbm mutation (0 available); any Erbb2 mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

demyelination ( J:199150 )

• peripheral without Schwann cell turn-over

behavior/neurological

behavior/neurological phenotype ( J:199150 )

N	• mice exhibit normal motor coordination

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:77347 )

• 27% die before reaching 6 months of age and 20% die during echochardiographic or ECG examination

postnatal lethality, incomplete penetrance ( J:77347 )

• 16% die within the first 2 weeks, the rest reach adulthood

cardiovascular system

abnormal myocardial fiber morphology ( J:77347 )

• adults and 3 month old mice exhibit myofiber hypertrophy

• frequently observe enlarged cardiomyocyte nuclei with abnormal morphology

cardiac hypertrophy ( J:77347 )

• heart-to-body weight ratios of adults are increased by 26%, indicative of hypertrophy

increased heart ventricle size ( J:77347 )

• adults exhibit enlarged ventricular chambers

thin ventricular wall ( J:77347 )

• seen in adults

dilated cardiomyopathy ( J:77347 )

• progressive malfunction of the heart

decreased heart ventricle muscle contractility ( J:77347 )

• at 3 months of age, ventricular diameter is increased and fractional shortening is impaired

• hearts do not compensate after aortic banding but display a further decrease in fractional shortening

decreased heart left ventricle muscle contractility ( J:77347 )

• at 1 month of age, see dilatation and loss of left ventricle contractility

prolonged QT interval ( J:77347 )

• significantly lengthened QT_c interval caused by a slowed ventricular repolarization

muscle