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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		E2f3tm1.1Gle
targeted mutation 1.1, Gustavo Leone
MGI:2177317
Summary 8 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		E2f3tm1.1Gle/E2f3tm1.1Gle 129-E2f3tm1.1Gle MGI:3806826
hm2
 		E2f3tm1.1Gle/E2f3tm1.1Gle B6.129P2-E2f3tm1.1Gle MGI:3806825
hm3
 		E2f3tm1.1Gle/E2f3tm1.1Gle FVB.129P2-E2f3tm1.1Gle MGI:3806824
hm4
 		E2f3tm1.1Gle/E2f3tm1.1Gle involves: 129P2/OlaHsd * C57BL/6J MGI:3806828
hm5
 		E2f3tm1.1Gle/E2f3tm1.1Gle involves: 129P2/OlaHsd * C57BL/6J * FVB MGI:3806829
hm6
 		E2f3tm1.1Gle/E2f3tm1.1Gle involves: 129P2/OlaHsd * FVB MGI:3806830
cn7
 		E2f3tm1.1Gle/E2f3tm1.1Gle
Rbl1tm1Htr/Rbl1tm1Htr
Tg(Pax6-cre,GFP)2Pgr/? 		involves: 129 * C57BL/6 * FVB/N * NMRI MGI:3722920
cn8
 		E2f1tm1Meg/E2f1tm1Meg
E2f3tm1.1Gle/E2f3tm1.1Gle
Rbl1tm1Htr/Rbl1tm1Htr
Tg(Pax6-cre,GFP)2Pgr/? 		involves: 129 * C57BL/6 * FVB/N * NMRI MGI:3722927


Genotype
MGI:3806826
hm1
Allelic
Composition		 E2f3tm1.1Gle/E2f3tm1.1Gle
Genetic
Background		 129-E2f3tm1.1Gle
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f3tm1.1Gle mutation (0 available); any E2f3 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:138289 )
• Background Sensitivity: unlike mice on a mixed background, mice on a pure 129 background display complete embryonic lethality




Genotype
MGI:3806825
hm2
Allelic
Composition		 E2f3tm1.1Gle/E2f3tm1.1Gle
Genetic
Background		 B6.129P2-E2f3tm1.1Gle
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f3tm1.1Gle mutation (0 available); any E2f3 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:138289 )
• Background Sensitivity: unlike mice on a mixed background, mice on a congenic C57BL/6J background display complete embryonic lethality




Genotype
MGI:3806824
hm3
Allelic
Composition		 E2f3tm1.1Gle/E2f3tm1.1Gle
Genetic
Background		 FVB.129P2-E2f3tm1.1Gle
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f3tm1.1Gle mutation (0 available); any E2f3 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:138289 )
• Background Sensitivity: unlike mice on a mixed background, mice on a congenic FVB background display complete embryonic lethality




Genotype
MGI:3806828
hm4
Allelic
Composition		 E2f3tm1.1Gle/E2f3tm1.1Gle
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f3tm1.1Gle mutation (0 available); any E2f3 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:138289 )
N
• Background Sensitivity: unlike mice on an inbred background, in mice on a mixed background no significant embryonic lethality is seen




Genotype
MGI:3806829
hm5
Allelic
Composition		 E2f3tm1.1Gle/E2f3tm1.1Gle
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f3tm1.1Gle mutation (0 available); any E2f3 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:138289 )
N
• Background Sensitivity: unlike mice on an inbred background, in mice on a mixed background no significant embryonic lethality is seen




Genotype
MGI:3806830
hm6
Allelic
Composition		 E2f3tm1.1Gle/E2f3tm1.1Gle
Genetic
Background		 involves: 129P2/OlaHsd * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f3tm1.1Gle mutation (0 available); any E2f3 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:138289 )
N
• Background Sensitivity: unlike mice on an inbred background, in mice on a mixed background no significant embryonic lethality is seen




Genotype
MGI:3722920
cn7
Allelic
Composition		 E2f3tm1.1Gle/E2f3tm1.1Gle
Rbl1tm1Htr/Rbl1tm1Htr
Tg(Pax6-cre,GFP)2Pgr/?
Genetic
Background		 involves: 129 * C57BL/6 * FVB/N * NMRI
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f3tm1.1Gle mutation (0 available); any E2f3 mutation (33 available)
Rbl1tm1Htr mutation (0 available); any Rbl1 mutation (60 available)
Tg(Pax6-cre,GFP)2Pgr mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
decreased retina ganglion cell number ( J:124204 )
• apoptosis eliminates most retinal ganglion cells
decreased retina rod cell number ( J:124204 )
• apoptosis eliminates many rod cells
abnormal amacrine cell morphology ( J:124204 )
• while present, starburst amacrine cell (SAC) tracks are slightly disordered due to a lack of synaptic partner cells
• however, markers of SAC differentiation are restored
• 91% of Camk2a+ SAC express Chat and Slc18a3 compared to 60% in wild-type mice, 5.6% in Rbl1 null mice and 3.7% in Rb/E2f1 null mice due to the presence of Camk2a+ ganglion cells that would normally be killed by apoptosis
abnormal retina bipolar cell morphology ( J:124204 )
• apoptosis eliminates most bipolar cells
abnormal eye development ( J:124204 )
• retinal transition cells (RTC) undergo ectopic cell divisions
• however, markers of starburst amacrine cell differentiation are restored

nervous system
decreased retina ganglion cell number ( J:124204 )
• apoptosis eliminates most retinal ganglion cells
decreased retina rod cell number ( J:124204 )
• apoptosis eliminates many rod cells
abnormal amacrine cell morphology ( J:124204 )
• while present, starburst amacrine cell (SAC) tracks are slightly disordered due to a lack of synaptic partner cells
• however, markers of SAC differentiation are restored
• 91% of Camk2a+ SAC express Chat and Slc18a3 compared to 60% in wild-type mice, 5.6% in Rbl1 null mice and 3.7% in Rb/E2f1 null mice due to the presence of Camk2a+ ganglion cells that would normally be killed by apoptosis
abnormal retina bipolar cell morphology ( J:124204 )
• apoptosis eliminates most bipolar cells




Genotype
MGI:3722927
cn8
Allelic
Composition		 E2f1tm1Meg/E2f1tm1Meg
E2f3tm1.1Gle/E2f3tm1.1Gle
Rbl1tm1Htr/Rbl1tm1Htr
Tg(Pax6-cre,GFP)2Pgr/?
Genetic
Background		 involves: 129 * C57BL/6 * FVB/N * NMRI
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f1tm1Meg mutation (2 available); any E2f1 mutation (28 available)
E2f3tm1.1Gle mutation (0 available); any E2f3 mutation (33 available)
Rbl1tm1Htr mutation (0 available); any Rbl1 mutation (60 available)
Tg(Pax6-cre,GFP)2Pgr mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
vision/eye phenotype ( J:124204 )
N
• bipolar and ganglion cell death, starburst amacrine cell (SAC) differentiation, and SAC track disorder observed in Rbl1 null, Rbl1/E2f3 null or Rbl1/E2f1 null mice are rescued




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory