About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(KRT5-cre/ERT2)2Ipc
transgene insertion 2, I Pierre Chambon
MGI:2177429
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Tg(KRT5-cre/ERT2)2Ipc/0
Upf3atm1.1Wilk/Upf3atm1.1Wilk 		involves: 129 * 129S4/SvJaeSor * C57BL/6 * SJL MGI:6117764
cn2
 		Foxn1tm1.1Dmsu/Foxn1tm1.1Dmsu
Tg(KRT5-cre/ERT2)2Ipc/0 		involves: 129/Sv * C57BL/6 * SJL MGI:4454659


Genotype
MGI:6117764
cn1
Allelic
Composition		 Tg(KRT5-cre/ERT2)2Ipc/0
Upf3atm1.1Wilk/Upf3atm1.1Wilk
Genetic
Background		 involves: 129 * 129S4/SvJaeSor * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(KRT5-cre/ERT2)2Ipc mutation (3 available)
Upf3atm1.1Wilk mutation (0 available); any Upf3a mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell physiology ( J:234504 )
• reduced expression of NMD (nonsense-mediated decay) target transcripts Atf4, Cdh11, Ern2, Smad5 and Smad7 in olfactory epithelium




Genotype
MGI:4454659
cn2
Allelic
Composition		 Foxn1tm1.1Dmsu/Foxn1tm1.1Dmsu
Tg(KRT5-cre/ERT2)2Ipc/0
Genetic
Background		 involves: 129/Sv * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxn1tm1.1Dmsu mutation (1 available); any Foxn1 mutation (106 available)
Tg(KRT5-cre/ERT2)2Ipc mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Thymic atrophy in tamoxifen treated Foxn1tm1.1Dmsu/Foxn1tm1.1Dmsu Tg(KRT5-cre/ERT2)2Ipc/0 mice and Foxn1tm1.1Dmsu/Foxn1tm1.1Dmsu Tg(CAG-cre/Esr1*)5Amc/0 mice

immune system
abnormal thymus corticomedullary boundary morphology ( J:159773 )
• following tamoxifen treatment, the medullary region architecture is altered and the corticomedullary junction becomes indistinct compared to in wild-type mice
abnormal thymus medulla morphology ( J:159773 )
• following tamoxifen treatment, the medullary region architecture is altered and the corticomedullary junction becomes indistinct compared to in wild-type mice
small thymus ( J:159773 )
• following tamoxifen treatment
thymus atrophy ( J:159773 )
• following tamoxifen treatment
decreased thymocyte number ( J:159773 )
• following tamoxifen treatment

hematopoietic system
abnormal thymus corticomedullary boundary morphology ( J:159773 )
• following tamoxifen treatment, the medullary region architecture is altered and the corticomedullary junction becomes indistinct compared to in wild-type mice
abnormal thymus medulla morphology ( J:159773 )
• following tamoxifen treatment, the medullary region architecture is altered and the corticomedullary junction becomes indistinct compared to in wild-type mice
small thymus ( J:159773 )
• following tamoxifen treatment
thymus atrophy ( J:159773 )
• following tamoxifen treatment
decreased thymocyte number ( J:159773 )
• following tamoxifen treatment

endocrine/exocrine glands
abnormal thymus corticomedullary boundary morphology ( J:159773 )
• following tamoxifen treatment, the medullary region architecture is altered and the corticomedullary junction becomes indistinct compared to in wild-type mice
abnormal thymus medulla morphology ( J:159773 )
• following tamoxifen treatment, the medullary region architecture is altered and the corticomedullary junction becomes indistinct compared to in wild-type mice
small thymus ( J:159773 )
• following tamoxifen treatment
thymus atrophy ( J:159773 )
• following tamoxifen treatment
decreased thymocyte number ( J:159773 )
• following tamoxifen treatment




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory