Phenotypes associated with this allele

• Allele Symbol: Gad1^tm1Mrc
• Allele Name: targeted mutation 1, Mario R Capecchi
• Allele ID: MGI:2177566
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gad1^tm1Mrc/Gad1^tm1Mrc	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:2177571

Genotype
MGI:2177571

hm1

• Allelic Composition: Gad1^tm1Mrc/Gad1^tm1Mrc
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Cleft palate phenotype in Gad1^tm1Mrc/Gad1^tm1Mrc mice

mortality/aging

neonatal lethality, complete penetrance ( J:43954 )

• die shortly after birth

craniofacial

narrow maxilla ( J:43954 )

• observe some narrowing of the maxilla

• however, the mandible is normal

palatal shelves fail to meet at midline ( J:43954 )

• in newborns and E18.5 day mutant fetuses, the palatal shelves do elevate but fail to fuse

cleft secondary palate ( J:43954 )

• 92% of homozygotes exhibit a complete cleft of the secondary palate

• palatal shelves do elevate but fail to fuse

skeleton

narrow maxilla ( J:43954 )

• observe some narrowing of the maxilla

• however, the mandible is normal

digestive/alimentary system

palatal shelves fail to meet at midline ( J:43954 )

• in newborns and E18.5 day mutant fetuses, the palatal shelves do elevate but fail to fuse

cleft secondary palate ( J:43954 )

• 92% of homozygotes exhibit a complete cleft of the secondary palate

• palatal shelves do elevate but fail to fuse

meteorism ( J:43954 )

• mice frequently aspirate air into their intestinal tracts

homeostasis/metabolism

cyanosis ( J:43954 )

dehydration ( J:43954 )

hypoxia ( J:43954 )

• E18.5 fetuses delivered by caesarean sections are distinguishable from controls by their blue skin, suggesting hypoxia

behavior/neurological

abnormal suckling behavior ( J:43954 )

• homozygotes that survive birth fail to nurse, leading to fetal dehydration

growth/size/body

palatal shelves fail to meet at midline ( J:43954 )

• in newborns and E18.5 day mutant fetuses, the palatal shelves do elevate but fail to fuse

cleft secondary palate ( J:43954 )

• 92% of homozygotes exhibit a complete cleft of the secondary palate

• palatal shelves do elevate but fail to fuse

meteorism ( J:43954 )

• mice frequently aspirate air into their intestinal tracts