Phenotypes associated with this allele

• Allele Symbol: Myc^tm1Atp
• Allele Name: targeted mutation 1, Andreas Trumpp
• Allele ID: MGI:2177578
• Summary: 12 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Myc^tm1Atp/Myc^tm1Atp	involves: 129P2/OlaHsd	MGI:2655680
hm2	Myc^tm1Atp/Myc^tm1Atp	involves: 129P2/OlaHsd * FVB/N	MGI:3811815
ht3	Myc^tm1Atp/Myc^+	B6.129P2-Myc^tm1Atp	MGI:3811831
ht4	Myc^tm1Atp/Myc^+	involves: 129P2/OlaHsd * FVB/N	MGI:3811816
ht5	Myc^tm1Atp/Myc^tm2.1Atp	involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL	MGI:3811819
cn6	Myc^tm1Atp/Myc^tm2.1Atp Tg(Mx1-cre)1Cgn/0	involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N * SJL	MGI:3811820
cx7	Cdkn1b^tm1Mlf/Cdkn1b^+ Myc^tm1Atp/Myc^+	involves: 129P2/OlaHsd * 129S4/SvJaeSor * FVB/N	MGI:3811822
cx8	Cdkn1b^tm1Mlf/Cdkn1b^tm1Mlf Myc^tm1Atp/Myc^+	involves: 129P2/OlaHsd * 129S4/SvJaeSor * FVB/N	MGI:3811821
cx9	Cdkn1b^tm1Mlf/Cdkn1b^tm1Mlf Myc^tm1Atp/Myc^tm1Atp	involves: 129P2/OlaHsd * 129S4/SvJaeSor * FVB/N	MGI:3811823
cx10	Il15^tm1Imx/Il15^+ Myc^tm1Atp/Myc^+	involves: 129P2/OlaHsd * C57BL/6	MGI:3811833
cx11	Il15^tm1Imx/Il15^tm1Imx Myc^tm1Atp/Myc^+	involves: 129P2/OlaHsd * C57BL/6	MGI:3811834
cx12	Del(15Rr316124-Rr313939)2Fsp/+ Myc^tm1Atp/Myc^+	involves: 129P2/OlaHsd * C57BL/6	MGI:7411328

Genotype
MGI:2655680

hm1

• Allelic Composition: Myc^tm1Atp/Myc^tm1Atp
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal chorion morphology ( J:137630 )

• fetal blood vessels and allantoic mesenchyme fail to invade the chorion compartment unlike in wild-type mice

abnormal placenta morphology ( J:137630 )

• mice exhibit abnormal chorioallantoic placenta with a failure of branching morphogenesis

• fewer proliferating cells are found within the placenta compared to in wild-type mice

placental labyrinth hypoplasia ( J:137630 )

abnormal trophoblast layer morphology ( J:137630 )

• the number of epithelial derived choronic-trophoblast cells is decreased compared to in wild-type mice

cardiovascular system

cardiovascular system phenotype ( J:137630 )

N • embryonic vasculature development is normal

Genotype
MGI:3811815

hm2

• Allelic Composition: Myc^tm1Atp/Myc^tm1Atp
• Genetic Background: involves: 129P2/OlaHsd * FVB/N

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:73369 )

• mice die at E10.5

hematopoietic system

absent common myeloid progenitor cells ( J:73369 )

• yolk sac cells fail to produce myeloid-like colonies as do wild-type cells in methylcellulose culture

absent erythroid progenitor cell ( J:73369 )

• yolk sac cells fail to produce erythroid-like colonies as do wild-type cells in methylcellulose culture

cellular

absent fibroblast proliferation ( J:73369 )

• mouse embryonic fibroblasts exhibit no proliferation in culture unlike wild-type cells

embryo

decreased embryo size ( J:73369 )

• at E9.5

pale yolk sac ( J:73369 )

• at E9.5

growth/size/body

decreased embryo size ( J:73369 )

• at E9.5

Genotype
MGI:3811831

ht3

• Allelic Composition: Myc^tm1Atp/Myc⁺
• Genetic Background: B6.129P2-Myc^tm1Atp

immune system

immune system phenotype ( J:132730 )

N • thymocyte development is normal

decreased T cell proliferation ( J:132730 )

• 60% of activated T cells remain in a resting state compared to 30% in wild-type mice

• mice exhibit a 2-fold decreased in the number of dividing cells compared to in wild-type mice

• antigen-specific memory CD8+ T cells exhibit a cell autonomous impaired homeostatic proliferation compared to in wild-type mice

• memory CD44^high CD8+ T cells exhibit impaired proliferation in response to IL15 compared to similarly treated wild-type cells

decreased memory T cell number ( J:132730 )

• the number of CD8+ CD44^high memory T cells is decreased between 2- and 3-fold compared to in wild-type mice

• however, steady state turnover and survival of memory T cells is normal

abnormal NK cell physiology ( J:132730 )

• NK cells exhibit a slight reduction in IL15 induced proliferation compared to similarly treated wild-type cells

• however, normal proliferation of NK cells was normal at high concentrations Il15

hematopoietic system

decreased T cell proliferation ( J:132730 )

• 60% of activated T cells remain in a resting state compared to 30% in wild-type mice

• mice exhibit a 2-fold decreased in the number of dividing cells compared to in wild-type mice

• antigen-specific memory CD8+ T cells exhibit a cell autonomous impaired homeostatic proliferation compared to in wild-type mice

• memory CD44^high CD8+ T cells exhibit impaired proliferation in response to IL15 compared to similarly treated wild-type cells

decreased memory T cell number ( J:132730 )

• the number of CD8+ CD44^high memory T cells is decreased between 2- and 3-fold compared to in wild-type mice

• however, steady state turnover and survival of memory T cells is normal

abnormal NK cell physiology ( J:132730 )

• NK cells exhibit a slight reduction in IL15 induced proliferation compared to similarly treated wild-type cells

• however, normal proliferation of NK cells was normal at high concentrations Il15

cellular

decreased T cell proliferation ( J:132730 )

• 60% of activated T cells remain in a resting state compared to 30% in wild-type mice

• mice exhibit a 2-fold decreased in the number of dividing cells compared to in wild-type mice

• antigen-specific memory CD8+ T cells exhibit a cell autonomous impaired homeostatic proliferation compared to in wild-type mice

• memory CD44^high CD8+ T cells exhibit impaired proliferation in response to IL15 compared to similarly treated wild-type cells

Genotype
MGI:3811816

ht4

• Allelic Composition: Myc^tm1Atp/Myc⁺
• Genetic Background: involves: 129P2/OlaHsd * FVB/N

immune system

decreased T cell proliferation ( J:73369 )

• the percent of T cells that proliferate in response to TCR stimulation is 43% compared to 69% in wild-type cells with fewer cells re-entering the cell cycle than in wild-type samples

spleen hypoplasia ( J:73369 )

lymph node hypoplasia ( J:73369 )

small lymphoid organs ( J:73369 )

• thymus, spleen, lymph node and bone marrow organ to body weight ratios are reduced compared to in wild-type mice

lymphoid hypoplasia ( J:73369 )

• in the spleen, lymph nodes and bone marrow

growth/size/body

decreased body size ( J:73369 )

• at birth

decreased body weight ( J:73369 )

• adult mice are 18% to 22% smaller than wild-type mice by weight

postnatal growth retardation ( J:73369 )

decreased fetal size ( J:73369 )

• at E16.5

cellular

decreased T cell proliferation ( J:73369 )

• the percent of T cells that proliferate in response to TCR stimulation is 43% compared to 69% in wild-type cells with fewer cells re-entering the cell cycle than in wild-type samples

decreased fibroblast proliferation ( J:73369 )

• mouse embryonic fibroblasts exhibit decreased proliferation in culture compared to wild-type cells

adipose tissue

decreased white adipose tissue amount ( J:73369 )

limbs/digits/tail

short tail ( J:73369 )

hematopoietic system

decreased T cell proliferation ( J:73369 )

• the percent of T cells that proliferate in response to TCR stimulation is 43% compared to 69% in wild-type cells with fewer cells re-entering the cell cycle than in wild-type samples

decreased bone marrow cell number ( J:73369 )

spleen hypoplasia ( J:73369 )

Genotype
MGI:3811819

ht5

• Allelic Composition: Myc^tm1Atp/Myc^tm2.1Atp
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

immune system

immune system phenotype ( J:73369 )

N • despite cellular defects in T cell proliferation, activated T cells blast normally

decreased T cell proliferation ( J:73369 )

• the percent of T cells that proliferate in response to TCR stimulation is 15% compared to 69% in wild-type cells with fewer cells re-entering the cell cycle then in wild-type samples

spleen hypoplasia ( J:73369 )

lymph node hypoplasia ( J:73369 )

growth/size/body

decreased body weight ( J:73369 )

• mice exhibit decreased weight compared to wild-type mice that is not as severe as in Myc^tm1Atp heterozygotes

hematopoietic system

decreased T cell proliferation ( J:73369 )

• the percent of T cells that proliferate in response to TCR stimulation is 15% compared to 69% in wild-type cells with fewer cells re-entering the cell cycle then in wild-type samples

decreased bone marrow cell number ( J:73369 )

spleen hypoplasia ( J:73369 )

cellular

decreased T cell proliferation ( J:73369 )

• the percent of T cells that proliferate in response to TCR stimulation is 15% compared to 69% in wild-type cells with fewer cells re-entering the cell cycle then in wild-type samples

Genotype
MGI:3811820

cn6

• Allelic Composition: Myc^tm1Atp/Myc^tm2.1Atp; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N * SJL

immune system

immune system phenotype ( J:73369 )

N • despite cellular defects in T cell proliferation, activated T cells exposed to pIpC blast normally

Genotype
MGI:3811822

cx7

• Allelic Composition: Cdkn1b^tm1Mlf/Cdkn1b⁺; Myc^tm1Atp/Myc⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * FVB/N

growth/size/body

decreased body size ( J:73369 )

• as in Myc^tm1Atp heterozygotes

Genotype
MGI:3811821

cx8

• Allelic Composition: Cdkn1b^tm1Mlf/Cdkn1b^tm1Mlf; Myc^tm1Atp/Myc⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * FVB/N

immune system

decreased T cell proliferation ( J:73369 )

• as in Myc^tm1Atp heterozygotes

growth/size/body

decreased body size ( J:73369 )

• as in Myc^tm1Atp heterozygotes

hematopoietic system

decreased T cell proliferation ( J:73369 )

• as in Myc^tm1Atp heterozygotes

cellular

decreased T cell proliferation ( J:73369 )

• as in Myc^tm1Atp heterozygotes

Genotype
MGI:3811823

cx9

• Allelic Composition: Cdkn1b^tm1Mlf/Cdkn1b^tm1Mlf; Myc^tm1Atp/Myc^tm1Atp
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * FVB/N

mortality/aging

prenatal lethality, complete penetrance ( J:73369 )

• mice die at mid-gestation

Genotype
MGI:3811833

cx10

• Allelic Composition: Il15^tm1Imx/Il15⁺; Myc^tm1Atp/Myc⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

hematopoietic system

decreased memory T cell number ( J:132730 )

• the number of CD8+ CD44^high memory T cells is decreased compared to in wild-type mice or single heterogyzotes

immune system

decreased memory T cell number ( J:132730 )

• the number of CD8+ CD44^high memory T cells is decreased compared to in wild-type mice or single heterogyzotes

Genotype
MGI:3811834

cx11

• Allelic Composition: Il15^tm1Imx/Il15^tm1Imx; Myc^tm1Atp/Myc⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

immune system

decreased NK cell number ( J:132730 )

decreased memory T cell number ( J:132730 )

• mice exhibit the same reduction in CD8+ CD44^high memory T cells as in Il15^tm1Imx Myc^tm1Atp heterozygotes

hematopoietic system

decreased NK cell number ( J:132730 )

decreased memory T cell number ( J:132730 )

• mice exhibit the same reduction in CD8+ CD44^high memory T cells as in Il15^tm1Imx Myc^tm1Atp heterozygotes

Genotype
MGI:7411328

cx12

• Allelic Composition: Del(15Rr316124-Rr313939)2Fsp/+; Myc^tm1Atp/Myc⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

hematopoietic system

hematopoietic system phenotype ( J:257739 )

N • normal number of MMP1, HSC and T cells and erythrocytes in bone marrow

increased myeloid cell number in bone marrow ( J:257739 )

• increased multipotent progenitor (MMP) populations 3 and 4

• normal number of MMP1 and HSC cells

decreased bone marrow cell number ( J:257739 )

• decreased B cell and granulocyte numbers

• normal number of MMP1 and HSC cells

increased megakaryocyte cell number ( J:257739 )

• increased megakaryocytic cell number in bone marrow

decreased granulocyte number ( J:257739 )

• in bone marrow

decreased B cell number ( J:257739 )

• in bone marrow

immune system

decreased granulocyte number ( J:257739 )

• in bone marrow

decreased B cell number ( J:257739 )

• in bone marrow