All Phenotypes Myc<tm2.1Atp> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Myc^tm2.1Atp/Myc⁺	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:3811817
ht2	Myc^tm1Atp/Myc^tm2.1Atp	involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL	MGI:3811819
cn3	Hnf4a^tm1(cre)Sdv/Hnf4a⁺ Myc^tm2.1Atp/Myc^tm2.1Atp	involves: 129P2/OlaHsd * 129S/SvEv	MGI:3811917
cn4	Myc^tm2.1Atp/Myc^tm2.1Atp Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:3811915
cn5	Myc^tm2.1Atp/Myc^tm2.1Atp Tg(Mx1-cre)1Cgn/0	involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N * SJL	MGI:3811825
cn6	Myc^tm1Atp/Myc^tm2.1Atp Tg(Mx1-cre)1Cgn/0	involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N * SJL	MGI:3811820
cn7	Myc^tm2.1Atp/Myc^tm2.1Atp Tg(Pdx1-cre)1Herr/0	involves: 129P2/OlaHsd * C57BL/6J * CBA/J	MGI:4412367
cn8	Myc^tm2.1Atp/Myc^tm2.1Atp Tg(Tek-cre)1Rwng/0	involves: 129P2/OlaHsd * FVB/N	MGI:3811916

Allelic Composition	Myc^tm2.1Atp/Myc⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myc^tm2.1Atp mutation (0 available); any Myc mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased T cell proliferation ( J:73369 )

• the percent of T cells that proliferate in response to TCR stimulation is 63% compared to 69% in wild-type cells with fewer cells re-entering the cell cycle then in wild-type samples

growth/size/body

decreased body weight ( J:73369 )

• mice exhibit decreased weight compared to wild-type mice that is not as severe as in Myc^tm1Atp heterozygotes

hematopoietic system

decreased T cell proliferation ( J:73369 )

• the percent of T cells that proliferate in response to TCR stimulation is 63% compared to 69% in wild-type cells with fewer cells re-entering the cell cycle then in wild-type samples

cellular

decreased T cell proliferation ( J:73369 )

• the percent of T cells that proliferate in response to TCR stimulation is 63% compared to 69% in wild-type cells with fewer cells re-entering the cell cycle then in wild-type samples

Allelic Composition	Myc^tm1Atp/Myc^tm2.1Atp
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myc^tm1Atp mutation (0 available); any Myc mutation (43 available)
Myc^tm2.1Atp mutation (0 available); any Myc mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:73369 )

N	• despite cellular defects in T cell proliferation, activated T cells blast normally

decreased T cell proliferation ( J:73369 )

• the percent of T cells that proliferate in response to TCR stimulation is 15% compared to 69% in wild-type cells with fewer cells re-entering the cell cycle then in wild-type samples

spleen hypoplasia ( J:73369 )

lymph node hypoplasia ( J:73369 )

growth/size/body

decreased body weight ( J:73369 )

• mice exhibit decreased weight compared to wild-type mice that is not as severe as in Myc^tm1Atp heterozygotes

hematopoietic system

decreased T cell proliferation ( J:73369 )

• the percent of T cells that proliferate in response to TCR stimulation is 15% compared to 69% in wild-type cells with fewer cells re-entering the cell cycle then in wild-type samples

decreased bone marrow cell number ( J:73369 )

spleen hypoplasia ( J:73369 )

cellular

decreased T cell proliferation ( J:73369 )

• the percent of T cells that proliferate in response to TCR stimulation is 15% compared to 69% in wild-type cells with fewer cells re-entering the cell cycle then in wild-type samples

Allelic Composition	Hnf4a^tm1(cre)Sdv/Hnf4a⁺ Myc^tm2.1Atp/Myc^tm2.1Atp
Genetic Background	involves: 129P2/OlaHsd * 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hnf4a^tm1(cre)Sdv mutation (2 available); any Hnf4a mutation (28 available)
Myc^tm2.1Atp mutation (0 available); any Myc mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:137630 )

N	• mice are viable

liver/biliary system

liver/biliary system phenotype ( J:137630 )

N	• liver size and morphology are normal

Allelic Composition	Myc^tm2.1Atp/Myc^tm2.1Atp Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3^{Tg(Sox2-cre)1Amc} mutation (5 available); any Edil3 mutation (43 available)
Myc^tm2.1Atp mutation (0 available); any Myc mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:137630 )

• mice die between E11.25 and E11.75

liver/biliary system

liver hypoplasia ( J:137630 )

hematopoietic system

abnormal common myeloid progenitor cell morphology ( J:137630 )

• when embryonic or yolk sac cells are cultured, few abnormal colony-forming unit-granulocyte/macrophage colonies form unlike when wild-type cells are cultured

impaired hematopoiesis ( J:137630 )

• despite normal numbers of hematopoietic stem cells, hematopoiesis is impaired

decreased erythroid progenitor cell number ( J:137630 )

• erythroblast precursors are decreased 1500-fold compared to in wild-type mice due to a 19-fold increased in apoptosis at E9.5 and a 41-fold increased at E10.5

• when embryonic or yolk sac cells are cultured, few abnormal blast-forming unit-erythroid colonies form unlike when wild-type cells are cultured

abnormal proerythroblast morphology ( J:137630 )

• the number of early basophilic erythroblasts is decreased 11.5-fold compared to in wild-type mice

embryo

decreased embryo size ( J:137630 )

• at E11.5

pale yolk sac ( J:137630 )

growth/size/body

decreased embryo size ( J:137630 )

• at E11.5

cardiovascular system

cardiovascular system phenotype ( J:137630 )

N	• embryonic vasculature development is normal

Allelic Composition	Myc^tm2.1Atp/Myc^tm2.1Atp Tg(Mx1-cre)1Cgn/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myc^tm2.1Atp mutation (0 available); any Myc mutation (43 available)
Tg(Mx1-cre)1Cgn mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

absent fibroblast proliferation ( J:73369 )

• following treatment with a retroviral cre, mouse embryonic fibroblasts fail to proliferate in culture unlike wild-type cells

immune system

immune system phenotype ( J:73369 )

N	• despite cellular defects in T cell proliferation, activated T cells blast normally

Allelic Composition	Myc^tm1Atp/Myc^tm2.1Atp Tg(Mx1-cre)1Cgn/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:73369 )

N	• despite cellular defects in T cell proliferation, activated T cells exposed to pIpC blast normally

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:146087 )

N	• at birth and 2 months, pancreatic contents of insulin and glucagon are similar to that of controls; islet architecture and function are normal

abnormal pancreas morphology ( J:146087 )

• in newborns, diminished surface occupied by exocrine pancreas is composed of poorly polarized acinar cells

• at 2 months, histology is grossly normal, but adipocytes accumulate in the parenchyma

• in 10 month old animals, adipose tissue is abundant; however pancreas weight is still reduced by 31%

• adipose replacement of acinar cells is gradual with 2 intermediate cells observed: acinar cells containing small lipid droplets and fat-laden cells containing zymogen but lacking other acinar markers; this suggests that acinar cells transdifferentiate into adipocytes in mature mutants

abnormal pancreatic acinus morphology ( J:146087 )

• loss of exocrine tissue affects 50% of the acinar mass

abnormal pancreatic acinar cell morphology ( J:146087 )

• acinar cells from newborns and adults have less amylase+ve and Cpa+ve zymogen granules than controls and are poorly polarized; in some pancreata, cellular localization of zymogen granules in adult cells is altered due to accumulation of lipid droplets

• some amylase containing zymogen granules are located within the thin cytoplasmic rim of adipocytes

• at 10 months, remaining acinar cells show similar dysmorphic traits to those in younger animals (see note above)

absent pancreatic acinar cells ( J:146087 )

• in 10 month-old animals, acinar cells are totally absent in entire pancreatic lobes

abnormal pancreatic duct morphology ( J:146087 )

• arborization of exocrine tree in newborns is reduced to 51% of controls and to 17% in adults

• loss of exocrine tissue affects 70% of the ductal mass

abnormal pancreas development ( J:146087 )

• growth of main pancreatic axes is unaffected but secondary branches are less developed at E15.5 and in newborns

• at E12.5, pancreata contain less proliferating pHH3+/Pdx1+/amylase -ve progenitor cells than controls

abnormal pancreas size ( J:146087 )

decreased pancreas weight ( J:146087 )

• at 2 months, pancreas weight is reduced to 55% of control weight

pancreas hypoplasia ( J:146087 )

• pancreas is hypoplastic from E12.5 onward

homeostasis/metabolism

abnormal enzyme/coenzyme activity ( J:146087 )

• at birth amylase activity in pancreatic extracts is 7% of controls, but recovers to 57% by 2 months of age; amylase acitivity per gram/pancreas is reduced 4-fold in newborns and partially recovered at 2 months

digestive/alimentary system

abnormal pancreatic acinus morphology ( J:146087 )

• loss of exocrine tissue affects 50% of the acinar mass

abnormal pancreatic acinar cell morphology ( J:146087 )

• some amylase containing zymogen granules are located within the thin cytoplasmic rim of adipocytes

• at 10 months, remaining acinar cells show similar dysmorphic traits to those in younger animals (see note above)

absent pancreatic acinar cells ( J:146087 )

• in 10 month-old animals, acinar cells are totally absent in entire pancreatic lobes

abnormal pancreatic duct morphology ( J:146087 )

• arborization of exocrine tree in newborns is reduced to 51% of controls and to 17% in adults

• loss of exocrine tissue affects 70% of the ductal mass

Allelic Composition	Myc^tm2.1Atp/Myc^tm2.1Atp Tg(Tek-cre)1Rwng/0
Genetic Background	involves: 129P2/OlaHsd * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myc^tm2.1Atp mutation (0 available); any Myc mutation (43 available)
Tg(Tek-cre)1Rwng mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:137630 )

• mice die at E11.5

liver/biliary system

abnormal liver morphology ( J:137630 )

• liver cells exhibit a mesenchymal rather than epithelial organization

small liver ( J:137630 )

liver hypoplasia ( J:137630 )

• the decrease in liver size is greater than can be numerically accounted for by hypoplasia

hematopoietic system

abnormal hematopoietic system morphology/development ( J:137630 )

• mice exhibit a hematopoietic phenotype identical to that observed in Myc^tm2.1Atp/Myc^tm2.1Atp Tg(Sox2-cre)1Amc mice

embryo

pale yolk sac ( J:137630 )

cardiovascular system

cardiovascular system phenotype ( J:137630 )

N	• embryonic vasculature development is normal

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