All Phenotypes Tg(Lck-cre)I57Jxm MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Lck-cre)I57Jxm
transgene insertion I57, Jamey Marth
MGI:2177584

Summary

28 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Elavl1^tm1Dkon/Elavl1^tm1Dkon Tg(Lck-cre)I57Jxm/0	B6.Cg-Elavl1^tm1Dkon Tg(Lck-cre)I57Jxm	MGI:3847929
cn2	Elavl1^tm1Dkon/Elavl1^tm1Dkon Tg(Lck-cre)I57Jxm/0 Tg(TcraH-Y,TcrbH-Y)71Vbo/?	B6.Cg-Elavl1^tm1Dkon Tg(Lck-cre)I57Jxm Tg(TcraH-Y,TcrbH-Y)71Vbo	MGI:3847930
cn3	Fas^tm1Cgn/Fas^tm1Cgn Tg(Lck-cre)I57Jxm/0	B6.Cg-Fas^tm1Cgn Tg(Lck-cre)I57Jxm	MGI:3690547
cn4	Nr3c1^tm2Gsc/Nr3c1^tm2Gsc Tg(Lck-cre)I57Jxm/0	B6.Cg-Nr3c1^tm2Gsc Tg(Lck-cre)I57Jxm	MGI:3817872
cn5	Stat5a^tm2Mam/Stat5a^tm2Mam Stat5b^tm1Mam/Stat5b^tm1Mam Tg(Lck-cre)I57Jxm/0	involves: 129 * 129S6/SvEvTac * C57BL/6 * ICR	MGI:4839921
cn6	Stat5b^tm1Mam/Stat5b^tm1Mam Tg(Lck-cre)I57Jxm/0	involves: 129 * 129S6/SvEvTac * C57BL/6 * ICR	MGI:4839922
cn7	Birc5^tm1Mak/Birc5^tm1Mak Tg(Lck-cre)I57Jxm/0	involves: 129P2/OlaHsd	MGI:3046207
cn8	Cd19^tm1(cre)Cgn/Cd19⁺ Ltbr^tm1Avt/Ltbr^tm1Avt Tg(Lck-cre)I57Jxm/0	involves: 129P2/OlaHsd	MGI:4453323
cn9	Cbl^tm2Hua/Cbl^tm2Hua Cblb^tm1Hua/Cblb^tm1Hua Tg(Lck-cre)I57Jxm/0	involves: 129P2/OlaHsd * C57BL/6 * ICR	MGI:2652089
cn10	Socs1^tm1Wehi/Socs1^tm3Wehi Tg(Lck-cre)I57Jxm/0	involves: 129P2/OlaHsd * C57BL/6 * ICR	MGI:2656984
cn11	Igbp1^tm1Imku/Y Tg(Lck-cre)I57Jxm/?	involves: 129P2/OlaHsd * ICR	MGI:3603799
cn12	Polb^tm1Rsky/Polb^tm1Rsky Tg(Lck-cre)I57Jxm/0	involves: 129P2/OlaHsd * ICR	MGI:3763215
cn13	Tnf^tm2.1Gkl/Tnf^tm2.1Gkl Tg(Lck-cre)I57Jxm/0	involves: 129S/SvEv * ICR	MGI:3629599
cn14	Srsf2^tm1Xdfu/Srsf2^tm1Xdfu Tg(Lck-cre)I57Jxm/?	involves: 129S4/SvJae * 129X1/SvJ * ICR	MGI:3037198
cn15	Srsf2^tm1Xdfu/Srsf2⁺ Tg(Lck-cre)I57Jxm/?	involves: 129S4/SvJae * 129X1/SvJ * ICR	MGI:3037204
cn16	Fadd^tm1Wnt/Fadd^tm1Wnt Tg(Fadd)33Wnt/0 Tg(Lck-cre)I57Jxm/0 Tg(Tcra2C,Tcrb2C)1Dlo/0	involves: 129S4/SvJae * C57BL/6 * C57L * CBA * ICR * SJL	MGI:4358109
cn17	Fadd^tm1Wnt/Fadd^tm1Wnt Tg(Fadd)33Wnt/0 Tg(Lck-cre)I57Jxm/0	involves: 129S4/SvJae * C57BL/6 * CBA * ICR	MGI:4358108
cn18	Stam^tm2Sug/Stam^tm2Sug Stam2^tm1Sug/Stam2^tm1Sug Tg(Lck-cre)I57Jxm/0	involves: 129S4/SvJae * C57BL/6 * ICR	MGI:3029479
cn19	Gt(ROSA)26Sor^{tm2(ITK/Syk)Hjum}/Gt(ROSA)26Sor⁺ Tg(Lck-cre)I57Jxm/0	involves: 129S6/SvEvTac * ICR	MGI:5586736
cn20	Arnt^tm1.1Gonz/Arnt^tm1.2Gonz Tg(Lck-cre)I57Jxm/0	involves: 129X1/SvJ * ICR	MGI:2679368
cn21	Ikbkb^tm1Cgn/Ikbkb^tm1Cgn Tg(Lck-cre)I57Jxm/0	involves: C57BL/6 * ICR	MGI:2679018
cn22	Tg(Lck-cre)I57Jxm/? Traf2^tm1Rbr/Traf2^tm1Rbr	involves: C57BL/6 * ICR	MGI:3777349
cn23	Tg(Lck-cre)I57Jxm/? Traf3^tm1Rbr/Traf3^tm1Rbr	involves: C57BL/6 * ICR * SJL	MGI:3777350
cn24	Nfatc3^tm1Grc/Nfatc3^tm1Grc Tg(Lck-cre)I57Jxm/0	involves: ICR	MGI:3820650
cn25	Nfatc2^tm1Rao/Nfatc2^tm1Rao Nfatc3^tm1Grc/Nfatc3^tm1Grc Tg(Lck-cre)I57Jxm/0	involves: ICR	MGI:3820653
cn26	Relb^tm1.1Fwei/Relb^tm1.1Fwei Tg(Lck-cre)I57Jxm/0	involves: ICR	MGI:5441216
cn27	Rela^tm1Rsch/Rela^tm1Rsch Tg(Lck-cre)I57Jxm/0	involves: ICR	MGI:5441218
cn28	Ltbr^tm1Avt/Ltbr^tm1Avt Tg(Lck-cre)I57Jxm/0	Not Specified	MGI:4453322

Allelic Composition	Elavl1^tm1Dkon/Elavl1^tm1Dkon Tg(Lck-cre)I57Jxm/0
Genetic Background	B6.Cg-Elavl1^tm1Dkon Tg(Lck-cre)I57Jxm

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elavl1^tm1Dkon mutation (1 available); any Elavl1 mutation (43 available)
Tg(Lck-cre)I57Jxm mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal positive T cell selection ( J:148866 )

• there is a relative decrease in the DP thymocytes initiating (TCRbeta^intCD69^high) and undergoing (TCRbeta^highCD69^high)positive selection

increased double-negative T cell number ( J:148866 )

• double negative thymocyte numbers are significantly increased in number starting at 4 weeks of age

• the largest increase in numbers occur in the DN4 population

increased double-positive T cell number ( J:148866 )

• double positive thymocyte numbers are significantly increased in number starting at 10 weeks of age

decreased CD4-positive, alpha-beta T cell number ( J:148866 )

• splenic CD4⁺ T cell numbers are significantly less than controls

• with age, numbers drop below half that in controls

decreased CD8-positive, alpha-beta T cell number ( J:148866 )

• splenic CD8⁺ T cell numbers are significantly less than controls

• with age, numbers drop below half that in controls

increased single-positive T cell number ( J:148866 )

• double positive thymocyte numbers are significantly increased in number starting at 10 weeks of age

abnormal T cell physiology ( J:148866 )

• the ability of thymocytes to egress from the thymus is reduced in these mice

• the number of recent thymic emigrants in the periphery is reduced by about a third

• thymocytes migrate poorly to CXCL12 or CCR7

abnormal thymocyte activation ( J:148866 )

• about twice as many thymocytes in both the double negative and double positive subsets are in the S or G2/M phase

• thymocytes have a reduced response to TCR stimulation

hematopoietic system

abnormal positive T cell selection ( J:148866 )

• there is a relative decrease in the DP thymocytes initiating (TCRbeta^intCD69^high) and undergoing (TCRbeta^highCD69^high)positive selection

increased double-negative T cell number ( J:148866 )

• double negative thymocyte numbers are significantly increased in number starting at 4 weeks of age

• the largest increase in numbers occur in the DN4 population

increased double-positive T cell number ( J:148866 )

• double positive thymocyte numbers are significantly increased in number starting at 10 weeks of age

decreased CD4-positive, alpha-beta T cell number ( J:148866 )

• splenic CD4⁺ T cell numbers are significantly less than controls

• with age, numbers drop below half that in controls

decreased CD8-positive, alpha-beta T cell number ( J:148866 )

• splenic CD8⁺ T cell numbers are significantly less than controls

• with age, numbers drop below half that in controls

increased single-positive T cell number ( J:148866 )

• double positive thymocyte numbers are significantly increased in number starting at 10 weeks of age

abnormal T cell physiology ( J:148866 )

• the ability of thymocytes to egress from the thymus is reduced in these mice

• the number of recent thymic emigrants in the periphery is reduced by about a third

• thymocytes migrate poorly to CXCL12 or CCR7

abnormal thymocyte activation ( J:148866 )

• about twice as many thymocytes in both the double negative and double positive subsets are in the S or G2/M phase

• thymocytes have a reduced response to TCR stimulation

endocrine/exocrine glands

abnormal thymocyte activation ( J:148866 )

• about twice as many thymocytes in both the double negative and double positive subsets are in the S or G2/M phase

• thymocytes have a reduced response to TCR stimulation

Allelic Composition	Elavl1^tm1Dkon/Elavl1^tm1Dkon Tg(Lck-cre)I57Jxm/0 Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Genetic Background	B6.Cg-Elavl1^tm1Dkon Tg(Lck-cre)I57Jxm Tg(TcraH-Y,TcrbH-Y)71Vbo

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elavl1^tm1Dkon mutation (1 available); any Elavl1 mutation (43 available)
Tg(Lck-cre)I57Jxm mutation (1 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased thymocyte number ( J:148866 )

• there is a 50% increase in transgenic CD8 single-positive thymocytes in male mice

• however, there is no corresponding increase in transgenic CD8⁺ T cells in the periphery

abnormal negative T cell selection ( J:148866 )

• there is a 50% increase in transgenic CD8 single-positive thymocytes in male mice suggesting a defect in negative selection

hematopoietic system

increased thymocyte number ( J:148866 )

• there is a 50% increase in transgenic CD8 single-positive thymocytes in male mice

• however, there is no corresponding increase in transgenic CD8⁺ T cells in the periphery

abnormal negative T cell selection ( J:148866 )

• there is a 50% increase in transgenic CD8 single-positive thymocytes in male mice suggesting a defect in negative selection

endocrine/exocrine glands

increased thymocyte number ( J:148866 )

• there is a 50% increase in transgenic CD8 single-positive thymocytes in male mice

• however, there is no corresponding increase in transgenic CD8⁺ T cells in the periphery

Allelic Composition	Fas^tm1Cgn/Fas^tm1Cgn Tg(Lck-cre)I57Jxm/0
Genetic Background	B6.Cg-Fas^tm1Cgn Tg(Lck-cre)I57Jxm

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fas^tm1Cgn mutation (1 available); any Fas mutation (82 available)
Tg(Lck-cre)I57Jxm mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

lymph node hypoplasia ( J:114948 )

• at 7 months of age, lymph nodes contain fewer than 0.1 million cells

Allelic Composition	Nr3c1^tm2Gsc/Nr3c1^tm2Gsc Tg(Lck-cre)I57Jxm/0
Genetic Background	B6.Cg-Nr3c1^tm2Gsc Tg(Lck-cre)I57Jxm

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr3c1^tm2Gsc mutation (1 available); any Nr3c1 mutation (35 available)
Tg(Lck-cre)I57Jxm mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased T cell apoptosis ( J:137157 )

• T cells fail to exhibit an increase in apoptosis following treatment with dexamethasone unlike Nr3c1^tm2Gsc control cells

increased susceptibility to experimental autoimmune encephalomyelitis ( J:137157 )

• following exposure to MOG, mice exhibit earlier induction of experimental autoimmune encephalomyelitis than in similarly treated wild-type mice and fail to recover after treatment with dexamethasone as do Nr3c1^tm2Gsc control mice

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:137157 )

• T cells fail to exhibit an increase in apoptosis following treatment with dexamethasone unlike Nr3c1^tm2Gsc control cells

• following induction of experimental autoimmune encephalomyelitis and treatment with dexamethasone, regulatory T cell numbers are not as diminished as in Nr3c1^tm2Gsc control mice and expression of Foxp3 is unaltered

• unlike in peripheral T cells from Nr3c1^tm2Gsc control mice, treatment with dexamethasone does not reduced expression of cell adhesion molecules

cellular

decreased T cell apoptosis ( J:137157 )

• T cells fail to exhibit an increase in apoptosis following treatment with dexamethasone unlike Nr3c1^tm2Gsc control cells

hematopoietic system

decreased T cell apoptosis ( J:137157 )

• T cells fail to exhibit an increase in apoptosis following treatment with dexamethasone unlike Nr3c1^tm2Gsc control cells

Allelic Composition	Stat5a^tm2Mam/Stat5a^tm2Mam Stat5b^tm1Mam/Stat5b^tm1Mam Tg(Lck-cre)I57Jxm/0
Genetic Background	involves: 129 * 129S6/SvEvTac * C57BL/6 * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat5a^tm2Mam mutation (1 available); any Stat5a mutation (48 available)
Stat5b^tm1Mam mutation (0 available); any Stat5b mutation (33 available)
Tg(Lck-cre)I57Jxm mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

enlarged spleen ( J:122463 )

• splenomegaly starting at the age of 4 weeks

abnormal T cell subpopulation ratio ( J:122463 )

• increased ratio of CD4+ versus CD8+ cells in thymus, peripheral blood, spleen, and lymph nodes

decreased CD8-positive, alpha-beta T cell number ( J:122463 )

• reduction of CD8+ T cells in thymus, peripheral blood, spleen and lymph nodes

abnormal acute inflammation ( J:122463 )

• lymphoid organ infiltration starting at the age of 4 weeks

hematopoietic system

enlarged spleen ( J:122463 )

• splenomegaly starting at the age of 4 weeks

abnormal T cell subpopulation ratio ( J:122463 )

• increased ratio of CD4+ versus CD8+ cells in thymus, peripheral blood, spleen, and lymph nodes

decreased CD8-positive, alpha-beta T cell number ( J:122463 )

• reduction of CD8+ T cells in thymus, peripheral blood, spleen and lymph nodes

growth/size/body

enlarged spleen ( J:122463 )

• splenomegaly starting at the age of 4 weeks

Allelic Composition	Stat5b^tm1Mam/Stat5b^tm1Mam Tg(Lck-cre)I57Jxm/0
Genetic Background	involves: 129 * 129S6/SvEvTac * C57BL/6 * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat5b^tm1Mam mutation (0 available); any Stat5b mutation (33 available)
Tg(Lck-cre)I57Jxm mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

enlarged spleen ( J:122463 )

• splenomegaly starting at the age of 4 weeks

abnormal T cell subpopulation ratio ( J:122463 )

• increased ratio of CD4+ versus CD8+ cells in thymus, peripheral blood, spleen, and lymph nodes

decreased CD8-positive, alpha-beta T cell number ( J:122463 )

• reduction of CD8+ T cells in thymus, peripheral blood, spleen and lymph nodes

abnormal acute inflammation ( J:122463 )

• lymphoid organ infiltration starting at the age of 4 weeks

hematopoietic system

enlarged spleen ( J:122463 )

• splenomegaly starting at the age of 4 weeks

abnormal T cell subpopulation ratio ( J:122463 )

• increased ratio of CD4+ versus CD8+ cells in thymus, peripheral blood, spleen, and lymph nodes

decreased CD8-positive, alpha-beta T cell number ( J:122463 )

• reduction of CD8+ T cells in thymus, peripheral blood, spleen and lymph nodes

growth/size/body

enlarged spleen ( J:122463 )

• splenomegaly starting at the age of 4 weeks

Allelic Composition	Birc5^tm1Mak/Birc5^tm1Mak Tg(Lck-cre)I57Jxm/0
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Birc5^tm1Mak mutation (1 available); any Birc5 mutation (20 available)
Tg(Lck-cre)I57Jxm mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell cycle ( J:90892 )

• more CD25⁺CD44^- double negative cells are in G1 and fewer are in S indicating cell cycle arrest

• no typical telophase cells can be found among the Birc5 deficient cells

increased T cell apoptosis ( J:90892 )

• 37% CD25⁺CD44^-- and 32% of CD25^-CD44^- double negative cells are apoptotic compared to only 5-7% of cells in littermate controls

hematopoietic system

increased T cell apoptosis ( J:90892 )

• 37% CD25⁺CD44^-- and 32% of CD25^-CD44^- double negative cells are apoptotic compared to only 5-7% of cells in littermate controls

abnormal thymus corticomedullary boundary morphology ( J:90892 )

• the thymus lacks the normal cortex-medulla compartmentalization

small thymus ( J:90892 )

• the thymus is much smaller

abnormal T cell morphology ( J:90892 )

• shorter and thicker spindles are seen in mutant CD25⁺CD44^-- and CD25^-CD44^- double negative cells

• the vast majority of the cells in the thymus appear to be immature thymocytes

decreased thymocyte number ( J:90892 )

• the average number of thymocytes is about 2% that seen in littermate controls

decreased double-negative T cell number ( J:90892 )

• the overall number of DN cells is decreased however these now make up about 95% of the total thymocytes

• CD25⁺CD44^- DN cells make up about 80% of the total DN cells compared to less than 50% in littermate controls

• CD25^-CD44^- DN cells are reduced to about 4% of the total DN cells compared to less than about 30% in littermate controls

immune system

increased T cell apoptosis ( J:90892 )

• 37% CD25⁺CD44^-- and 32% of CD25^-CD44^- double negative cells are apoptotic compared to only 5-7% of cells in littermate controls

abnormal thymus corticomedullary boundary morphology ( J:90892 )

• the thymus lacks the normal cortex-medulla compartmentalization

small thymus ( J:90892 )

• the thymus is much smaller

abnormal T cell morphology ( J:90892 )

• shorter and thicker spindles are seen in mutant CD25⁺CD44^-- and CD25^-CD44^- double negative cells

• the vast majority of the cells in the thymus appear to be immature thymocytes

decreased thymocyte number ( J:90892 )

• the average number of thymocytes is about 2% that seen in littermate controls

decreased double-negative T cell number ( J:90892 )

• the overall number of DN cells is decreased however these now make up about 95% of the total thymocytes

• CD25⁺CD44^- DN cells make up about 80% of the total DN cells compared to less than 50% in littermate controls

• CD25^-CD44^- DN cells are reduced to about 4% of the total DN cells compared to less than about 30% in littermate controls

endocrine/exocrine glands

abnormal thymus corticomedullary boundary morphology ( J:90892 )

• the thymus lacks the normal cortex-medulla compartmentalization

small thymus ( J:90892 )

• the thymus is much smaller

decreased thymocyte number ( J:90892 )

• the average number of thymocytes is about 2% that seen in littermate controls

Allelic Composition	Cd19^tm1(cre)Cgn/Cd19⁺ Ltbr^tm1Avt/Ltbr^tm1Avt Tg(Lck-cre)I57Jxm/0
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19^tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Ltbr^tm1Avt mutation (0 available); any Ltbr mutation (47 available)
Tg(Lck-cre)I57Jxm mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:158663 )

N	• susceptibility to Citrobacter rodentium infection is similar to wild-type controls

Allelic Composition	Cbl^tm2Hua/Cbl^tm2Hua Cblb^tm1Hua/Cblb^tm1Hua Tg(Lck-cre)I57Jxm/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cblb^tm1Hua mutation (0 available); any Cblb mutation (58 available)
Cbl^tm2Hua mutation (0 available); any Cbl mutation (59 available)
Tg(Lck-cre)I57Jxm mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:80427 )

• female animals were moribund at 12 weeks of age; male animals were moribund at 16 weeks of age

cardiovascular system

abnormal blood vessel morphology ( J:80427 )

• thickened intima, thickened tunica aventitia and severe T cell infilatration

growth/size/body

decreased body weight ( J:80427 )

• weight gain lagged behind wild-type controls after 3 weeks of age

enlarged spleen ( J:80427 )

hematopoietic system

increased T cell proliferation ( J:80427 )

• in response to anti-CD3 stimulation

enlarged spleen ( J:80427 )

extramedullary hematopoiesis ( J:80427 )

abnormal T cell morphology ( J:80427 )

• enlarged T cells

immune system

enlarged spleen ( J:80427 )

abnormal T cell morphology ( J:80427 )

• enlarged T cells

abnormal immune system physiology ( J:80427 )

• lymphadenopathy

increased T cell proliferation ( J:80427 )

• in response to anti-CD3 stimulation

dermatitis ( J:80427 )

• subacute dermatitis

liver/biliary system

liver fibrosis ( J:80427 )

integument

dermatitis ( J:80427 )

• subacute dermatitis

cellular

increased T cell proliferation ( J:80427 )

• in response to anti-CD3 stimulation

Allelic Composition	Socs1^tm1Wehi/Socs1^tm3Wehi Tg(Lck-cre)I57Jxm/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Socs1^tm1Wehi mutation (3 available); any Socs1 mutation (30 available)
Socs1^tm3Wehi mutation (2 available); any Socs1 mutation (30 available)
Tg(Lck-cre)I57Jxm mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

enlarged thymus medulla ( J:83009 )

• enlarged thymic medulla

thymus hyperplasia ( J:83009 )

• increase in thymus cellularity predominately due to an increase in CD8+ T cell population

abnormal T cell differentiation ( J:83009 )

• enhanced differentiation of thymocytes toward CD8+ T cells

decreased B cell number ( J:83009 )

• large reduction in the percentage of non-T cells, mostly B cells, in the lymph nodes

abnormal T cell subpopulation ratio ( J:83009 )

• increase in the ratio of mature CD8 single positive:CD4 single positive thymocytes from 1:4 to 1:1

• increase in the ratio of CD8+:CD4+ T cells in the spleen, however total numbers of T cells are unchanged

abnormal CD4-positive, alpha beta T cell morphology ( J:83009 )

• mature thymocytes, both CD4 single positive and CD8 single positive, are larger in size

increased CD4-positive, alpha-beta T cell number ( J:83009 )

• increase in CD4+ T cells in the blood

abnormal CD8-positive, alpha beta T cell morphology ( J:83009 )

• mature thymocytes, both CD4 single positive and CD8 single positive, are larger in size

increased CD8-positive, alpha-beta T cell number ( J:83009 )

• large increase in the percentage and number of CD8 single positive thymocytes at 6 weeks of age

• increase in CD8+ T cells in the blood

abnormal T cell activation ( J:83009 )

• almost all peripheral CD8+ T cells but not CD4+ T cells appear as CD44^ho, indicating that they exhibit a memory rather than activated phenotype

enlarged lymph nodes ( J:83009 )

lymph node hyperplasia ( J:83009 )

• lymph nodes contain 2-fold the number of cells in controls

hematopoietic system

enlarged thymus medulla ( J:83009 )

• enlarged thymic medulla

thymus hyperplasia ( J:83009 )

• increase in thymus cellularity predominately due to an increase in CD8+ T cell population

abnormal T cell differentiation ( J:83009 )

• enhanced differentiation of thymocytes toward CD8+ T cells

decreased B cell number ( J:83009 )

• large reduction in the percentage of non-T cells, mostly B cells, in the lymph nodes

abnormal T cell subpopulation ratio ( J:83009 )

• increase in the ratio of mature CD8 single positive:CD4 single positive thymocytes from 1:4 to 1:1

• increase in the ratio of CD8+:CD4+ T cells in the spleen, however total numbers of T cells are unchanged

abnormal CD4-positive, alpha beta T cell morphology ( J:83009 )

• mature thymocytes, both CD4 single positive and CD8 single positive, are larger in size

increased CD4-positive, alpha-beta T cell number ( J:83009 )

• increase in CD4+ T cells in the blood

abnormal CD8-positive, alpha beta T cell morphology ( J:83009 )

• mature thymocytes, both CD4 single positive and CD8 single positive, are larger in size

increased CD8-positive, alpha-beta T cell number ( J:83009 )

• large increase in the percentage and number of CD8 single positive thymocytes at 6 weeks of age

• increase in CD8+ T cells in the blood

abnormal T cell activation ( J:83009 )

• almost all peripheral CD8+ T cells but not CD4+ T cells appear as CD44^ho, indicating that they exhibit a memory rather than activated phenotype

endocrine/exocrine glands

enlarged thymus medulla ( J:83009 )

• enlarged thymic medulla

thymus hyperplasia ( J:83009 )

• increase in thymus cellularity predominately due to an increase in CD8+ T cell population

Allelic Composition	Igbp1^tm1Imku/Y Tg(Lck-cre)I57Jxm/?
Genetic Background	involves: 129P2/OlaHsd * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igbp1^tm1Imku mutation (0 available); any Igbp1 mutation (10 available)
Tg(Lck-cre)I57Jxm mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal thymus cortex morphology ( J:84395 )

• largely lacking in double positive cells

abnormal thymus corticomedullary boundary morphology ( J:84395 )

• demarcation between cortex and medulla indistinct

decreased T cell number ( J:84395 )

• peripheral spleen T cells 30% of control levels

decreased thymocyte number ( J:84395 )

• thymocyte production only 4.3% normal

• few proliferating thymocytes

decreased double-negative T cell number ( J:84395 )

• double negative cells are proportionately higher but absolute numbers are reduced

• development blocked at DN3 stage

hematopoietic system

abnormal thymus cortex morphology ( J:84395 )

• largely lacking in double positive cells

abnormal thymus corticomedullary boundary morphology ( J:84395 )

• demarcation between cortex and medulla indistinct

decreased T cell number ( J:84395 )

• peripheral spleen T cells 30% of control levels

decreased thymocyte number ( J:84395 )

• thymocyte production only 4.3% normal

• few proliferating thymocytes

decreased double-negative T cell number ( J:84395 )

• double negative cells are proportionately higher but absolute numbers are reduced

• development blocked at DN3 stage

endocrine/exocrine glands

abnormal thymus cortex morphology ( J:84395 )

• largely lacking in double positive cells

abnormal thymus corticomedullary boundary morphology ( J:84395 )

• demarcation between cortex and medulla indistinct

decreased thymocyte number ( J:84395 )

• thymocyte production only 4.3% normal

• few proliferating thymocytes

Allelic Composition	Polb^tm1Rsky/Polb^tm1Rsky Tg(Lck-cre)I57Jxm/0
Genetic Background	involves: 129P2/OlaHsd * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Polb^tm1Rsky mutation (1 available); any Polb mutation (28 available)
Tg(Lck-cre)I57Jxm mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:67942 )

N	• no difference in T cell numbers or distribution of CD4 and CD8 expression is seen in the thymus and the number of Thy-1+ cells in the spleen is normal

Allelic Composition	Tnf^tm2.1Gkl/Tnf^tm2.1Gkl Tg(Lck-cre)I57Jxm/0
Genetic Background	involves: 129S/SvEv * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Lck-cre)I57Jxm mutation (1 available)
Tnf^tm2.1Gkl mutation (1 available); any Tnf mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

small intestinal inflammation ( J:108572 )

• mice develop mice develop inflammatory bowel disease past 5 months of age with reduced severity compared to Tnf^tm2.1Gkl, Lyzs^tm1(cre)Ifo double homozygotes or Tnf^tm2Gkl heterozygotes

digestive/alimentary system

small intestinal inflammation ( J:108572 )

• mice develop mice develop inflammatory bowel disease past 5 months of age with reduced severity compared to Tnf^tm2.1Gkl, Lyzs^tm1(cre)Ifo double homozygotes or Tnf^tm2Gkl heterozygotes

Allelic Composition	Srsf2^tm1Xdfu/Srsf2^tm1Xdfu Tg(Lck-cre)I57Jxm/?
Genetic Background	involves: 129S4/SvJae * 129X1/SvJ * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Srsf2^tm1Xdfu mutation (1 available); any Srsf2 mutation (11 available)
Tg(Lck-cre)I57Jxm mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

absent thymus corticomedullary boundary ( J:88668 )

• in histological sections the cortical-medullary junction is absent

small thymus ( J:88668 )

• the size and weight of the thymus is about 10% to 30% that in wild-types

• other peripheral lymphoid organs appear normal

abnormal T cell differentiation ( J:88668 )

• in T cells sorted by stage cells with the gene deleted are progressively eliminated

• splicing of CD45 is abnormal with a significant percentage of single positive and double positive T cells expressing CD45 isoforms missing exon 5

increased double-negative T cell number ( J:88668 )

• the percentage of double-negative T cells could be elevated up to 40% of the total (compared to 6% in wild-type)

• T cell development is arrested at the CD44^-CD25⁺ stage

decreased T cell number ( J:88668 )

• the absolute number of single positive T cells is greatly reduced

decreased thymocyte number ( J:88668 )

• a dramatic reduction in total thymocytes is seen

decreased double-positive T cell number ( J:88668 )

• the percentage of double-positive T cells could be decreased down to 50% of the total (compared to 85% in wild-type)

abnormal spleen white pulp morphology ( J:88668 )

• the white pulp is paler than normal

• the absolute number of single positive T cells is significantly reduced

• none of the mature T cells found in the spleen have the gene deleted

• the spleen is otherwise unaffected

immune system

absent thymus corticomedullary boundary ( J:88668 )

• in histological sections the cortical-medullary junction is absent

small thymus ( J:88668 )

• the size and weight of the thymus is about 10% to 30% that in wild-types

• other peripheral lymphoid organs appear normal

abnormal T cell differentiation ( J:88668 )

• in T cells sorted by stage cells with the gene deleted are progressively eliminated

• splicing of CD45 is abnormal with a significant percentage of single positive and double positive T cells expressing CD45 isoforms missing exon 5

increased double-negative T cell number ( J:88668 )

• the percentage of double-negative T cells could be elevated up to 40% of the total (compared to 6% in wild-type)

• T cell development is arrested at the CD44^-CD25⁺ stage

decreased double-positive T cell number ( J:88668 )

• the percentage of double-positive T cells could be decreased down to 50% of the total (compared to 85% in wild-type)

decreased T cell number ( J:88668 )

• the absolute number of single positive T cells is greatly reduced

decreased thymocyte number ( J:88668 )

• a dramatic reduction in total thymocytes is seen

abnormal spleen white pulp morphology ( J:88668 )

• the white pulp is paler than normal

• the absolute number of single positive T cells is significantly reduced

• none of the mature T cells found in the spleen have the gene deleted

• the spleen is otherwise unaffected

endocrine/exocrine glands

absent thymus corticomedullary boundary ( J:88668 )

• in histological sections the cortical-medullary junction is absent

small thymus ( J:88668 )

• the size and weight of the thymus is about 10% to 30% that in wild-types

• other peripheral lymphoid organs appear normal

decreased thymocyte number ( J:88668 )

• a dramatic reduction in total thymocytes is seen

Allelic Composition	Srsf2^tm1Xdfu/Srsf2⁺ Tg(Lck-cre)I57Jxm/?
Genetic Background	involves: 129S4/SvJae * 129X1/SvJ * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Srsf2^tm1Xdfu mutation (1 available); any Srsf2 mutation (11 available)
Tg(Lck-cre)I57Jxm mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased thymus weight ( J:88668 )

• a modest reduction in thymic weight is seen

decreased thymocyte number ( J:88668 )

• a modest reduction in the total number of thymocytes is seen

immune system

decreased thymus weight ( J:88668 )

• a modest reduction in thymic weight is seen

decreased thymocyte number ( J:88668 )

• a modest reduction in the total number of thymocytes is seen

endocrine/exocrine glands

decreased thymus weight ( J:88668 )

• a modest reduction in thymic weight is seen

decreased thymocyte number ( J:88668 )

• a modest reduction in the total number of thymocytes is seen

Allelic Composition	Fadd^tm1Wnt/Fadd^tm1Wnt Tg(Fadd)33Wnt/0 Tg(Lck-cre)I57Jxm/0 Tg(Tcra2C,Tcrb2C)1Dlo/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * C57L * CBA * ICR * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fadd^tm1Wnt mutation (0 available); any Fadd mutation (18 available)
Tg(Fadd)33Wnt mutation (0 available)
Tg(Lck-cre)I57Jxm mutation (1 available)
Tg(Tcra2C,Tcrb2C)1Dlo mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

thymus hypoplasia ( J:69617 )

increased double-negative T cell number ( J:69617 )

hematopoietic system

thymus hypoplasia ( J:69617 )

increased double-negative T cell number ( J:69617 )

endocrine/exocrine glands

thymus hypoplasia ( J:69617 )

Allelic Composition	Fadd^tm1Wnt/Fadd^tm1Wnt Tg(Fadd)33Wnt/0 Tg(Lck-cre)I57Jxm/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * CBA * ICR

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

thymus hypoplasia ( J:69617 )

• reduced 2-fold

abnormal T cell differentiation ( J:69617 )

• mice exhibit a slight increase in L cell stage (between DN3 and DN4) compared with wild-type mice

increased double-negative T cell number ( J:69617 )

• percent

decreased double-positive T cell number ( J:69617 )

• percent and absolute number

increased B cell number ( J:69617 )

• in the periphery

decreased CD4-positive, alpha-beta T cell number ( J:69617 )

• lower percentage in the periphery

decreased CD8-positive, alpha-beta T cell number ( J:69617 )

• lower percentage in the periphery

hematopoietic system

thymus hypoplasia ( J:69617 )

• reduced 2-fold

abnormal T cell differentiation ( J:69617 )

• mice exhibit a slight increase in L cell stage (between DN3 and DN4) compared with wild-type mice

increased double-negative T cell number ( J:69617 )

• percent

decreased double-positive T cell number ( J:69617 )

• percent and absolute number

increased B cell number ( J:69617 )

• in the periphery

decreased CD4-positive, alpha-beta T cell number ( J:69617 )

• lower percentage in the periphery

decreased CD8-positive, alpha-beta T cell number ( J:69617 )

• lower percentage in the periphery

endocrine/exocrine glands

thymus hypoplasia ( J:69617 )

• reduced 2-fold

Allelic Composition	Stam^tm2Sug/Stam^tm2Sug Stam2^tm1Sug/Stam2^tm1Sug Tg(Lck-cre)I57Jxm/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stam2^tm1Sug mutation (2 available); any Stam2 mutation (56 available)
Stam^tm2Sug mutation (1 available); any Stam mutation (43 available)
Tg(Lck-cre)I57Jxm mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased T cell proliferation ( J:80617 )

• responses to TCR stimulation and cytokines are severely impaired

decreased T cell number ( J:80617 )

• numbers of mature single positive CD4 or CD8 cells were reduced, and peripheral T cell numbers were reduced

immune system

decreased T cell proliferation ( J:80617 )

• responses to TCR stimulation and cytokines are severely impaired

decreased T cell number ( J:80617 )

• numbers of mature single positive CD4 or CD8 cells were reduced, and peripheral T cell numbers were reduced

cellular

decreased T cell proliferation ( J:80617 )

• responses to TCR stimulation and cytokines are severely impaired

Allelic Composition	Gt(ROSA)26Sor^{tm2(ITK/Syk)Hjum}/Gt(ROSA)26Sor⁺ Tg(Lck-cre)I57Jxm/0
Genetic Background	involves: 129S6/SvEvTac * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm2(ITK/Syk)Hjum} mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(Lck-cre)I57Jxm mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:207306 )

N	• mice exhibit normal percentages and total cell numbers of double positive or single positive thymocytes and CD4+ or CD8+ peripheral T cells in the spleen

increased mature B cell number ( J:207306 )

• in the spleen

increased plasma cell number ( J:207306 )

• in the spleen

increased CD4-positive, alpha-beta T cell number ( J:207306 )

increased activated T cell number ( J:207306 )

• CD4+ and CD8+ T cells in the spleen

abnormal spleen morphology ( J:207306 )

• with altered follicular structure and widely scattered T cells

enlarged spleen ( J:207306 )

• with expanded T cell pool, mainly CD4+ T cells

abnormal immunoglobulin level ( J:207306 )

increased IgA level ( J:207306 )

increased IgG level ( J:207306 )

increased IgM level ( J:207306 )

abnormal circulating cytokine level ( J:207306 )

increased circulating interferon-gamma level ( J:207306 )

increased circulating interleukin-10 level ( J:207306 )

• slightly

increased circulating interleukin-2 level ( J:207306 )

• slightly

increased circulating interleukin-4 level ( J:207306 )

increased circulating interleukin-6 level ( J:207306 )

• slightly

increased circulating tumor necrosis factor level ( J:207306 )

abnormal cytokine secretion ( J:207306 )

increased interferon-gamma secretion ( J:207306 )

• from un-stimulated splenic T cells

increased interleukin-10 secretion ( J:207306 )

• from un-stimulated and stimulated splenic T cells

increased interleukin-2 secretion ( J:207306 )

• from un-stimulated splenic T cells

increased interleukin-4 secretion ( J:207306 )

• from stimulated splenic T cells

increased interleukin-6 secretion ( J:207306 )

• from un-stimulated splenic T cells

increased tumor necrosis factor secretion ( J:207306 )

• from un-stimulated splenic T cells

increased inflammatory response ( J:207306 )

• systemic inflammation

liver/biliary system

abnormal liver morphology ( J:207306 )

homeostasis/metabolism

abnormal circulating cytokine level ( J:207306 )

increased circulating interferon-gamma level ( J:207306 )

increased circulating interleukin-10 level ( J:207306 )

• slightly

increased circulating interleukin-2 level ( J:207306 )

• slightly

increased circulating interleukin-4 level ( J:207306 )

increased circulating interleukin-6 level ( J:207306 )

• slightly

increased circulating tumor necrosis factor level ( J:207306 )

hematopoietic system

increased mature B cell number ( J:207306 )

• in the spleen

increased plasma cell number ( J:207306 )

• in the spleen

increased CD4-positive, alpha-beta T cell number ( J:207306 )

increased activated T cell number ( J:207306 )

• CD4+ and CD8+ T cells in the spleen

abnormal spleen morphology ( J:207306 )

• with altered follicular structure and widely scattered T cells

enlarged spleen ( J:207306 )

• with expanded T cell pool, mainly CD4+ T cells

abnormal immunoglobulin level ( J:207306 )

increased IgA level ( J:207306 )

increased IgG level ( J:207306 )

increased IgM level ( J:207306 )

growth/size/body

enlarged spleen ( J:207306 )

• with expanded T cell pool, mainly CD4+ T cells

Allelic Composition	Arnt^tm1.1Gonz/Arnt^tm1.2Gonz Tg(Lck-cre)I57Jxm/0
Genetic Background	involves: 129X1/SvJ * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arnt^tm1.1Gonz mutation (0 available); any Arnt mutation (65 available)
Arnt^tm1.2Gonz mutation (0 available); any Arnt mutation (65 available)
Tg(Lck-cre)I57Jxm mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal immune system physiology ( J:85934 )

• resistance to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induced thymic involution

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:85934 )

• resistance to the environmental pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induced thymic involution

Allelic Composition	Ikbkb^tm1Cgn/Ikbkb^tm1Cgn Tg(Lck-cre)I57Jxm/0
Genetic Background	involves: C57BL/6 * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikbkb^tm1Cgn mutation (0 available); any Ikbkb mutation (56 available)
Tg(Lck-cre)I57Jxm mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased CD4-positive, alpha-beta T cell number ( J:85810 )

• CD4+ T cell numbers are reduced in the spleen and lymph nodes

decreased CD8-positive, alpha-beta T cell number ( J:85810 )

• CD8+ T cell numbers are reduced in the spleen and lymph nodes

hematopoietic system

decreased CD4-positive, alpha-beta T cell number ( J:85810 )

• CD4+ T cell numbers are reduced in the spleen and lymph nodes

decreased CD8-positive, alpha-beta T cell number ( J:85810 )

• CD8+ T cell numbers are reduced in the spleen and lymph nodes

Allelic Composition	Tg(Lck-cre)I57Jxm/? Traf2^tm1Rbr/Traf2^tm1Rbr
Genetic Background	involves: C57BL/6 * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Lck-cre)I57Jxm mutation (1 available)
Traf2^tm1Rbr mutation (0 available); any Traf2 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased mature B cell number ( J:132877 )

• mature B cells are virtually absent from the lymph nodes

absent follicular B cells ( J:132877 )

• follicular B cells are absent from the spleen

absent marginal zone B cells ( J:132877 )

• marginal zone B cells are absent from the spleen

hematopoietic system

decreased mature B cell number ( J:132877 )

• mature B cells are virtually absent from the lymph nodes

absent follicular B cells ( J:132877 )

• follicular B cells are absent from the spleen

absent marginal zone B cells ( J:132877 )

• marginal zone B cells are absent from the spleen

Allelic Composition	Tg(Lck-cre)I57Jxm/? Traf3^tm1Rbr/Traf3^tm1Rbr
Genetic Background	involves: C57BL/6 * ICR * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Lck-cre)I57Jxm mutation (1 available)
Traf3^tm1Rbr mutation (0 available); any Traf3 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased CD4-positive, alpha-beta T cell number ( J:132877 )

• numbers of CD4 T cells in the spleen are slightly reduced

decreased CD8-positive, alpha-beta T cell number ( J:132877 )

• numbers of CD8 T cells in the spleen are slightly reduced

abnormal T cell physiology ( J:132877 )

• extensive activation of the alternative NF-kappaB pathway occurs though no effect on T cell survival is observed

hematopoietic system

decreased CD4-positive, alpha-beta T cell number ( J:132877 )

• numbers of CD4 T cells in the spleen are slightly reduced

decreased CD8-positive, alpha-beta T cell number ( J:132877 )

• numbers of CD8 T cells in the spleen are slightly reduced

abnormal T cell physiology ( J:132877 )

• extensive activation of the alternative NF-kappaB pathway occurs though no effect on T cell survival is observed

Allelic Composition	Nfatc3^tm1Grc/Nfatc3^tm1Grc Tg(Lck-cre)I57Jxm/0
Genetic Background	involves: ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfatc3^tm1Grc mutation (0 available); any Nfatc3 mutation (71 available)
Tg(Lck-cre)I57Jxm mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased T cell apoptosis ( J:141917 )

• in culture, the initial number of double positive T cell undergoing apoptosis is greater than for wild-type cells

• however, the rate of apoptosis in vitro is normal

thymus hypoplasia ( J:141917 )

• the total number of thymocytes is reduced by half of wild-type

decreased thymocyte number ( J:141917 )

• the total number of thymocytes is reduced by half of wild-type

• the number of single positive T cells in the thymus is lower than in wild-type mice

• however, the number of double positive cells is normal

abnormal T cell differentiation ( J:141917 )

• T cell development is partially blocked after pre-TCR signaling and the DN4 population is reduced compared to in wild-type mice

increased double-negative T cell number ( J:141917 )

• mice exhibit an increase in double negative T cell compared to in wild-type mice up to stage DN4

decreased CD4-positive, alpha-beta T cell number ( J:141917 )

• in the thymus

decreased CD8-positive, alpha-beta T cell number ( J:141917 )

• in the thymus

lymph node hypoplasia ( J:141917 )

• the total number of inguinal lymph node cells is decreased by half of wild-type

hematopoietic system

increased T cell apoptosis ( J:141917 )

• in culture, the initial number of double positive T cell undergoing apoptosis is greater than for wild-type cells

• however, the rate of apoptosis in vitro is normal

thymus hypoplasia ( J:141917 )

• the total number of thymocytes is reduced by half of wild-type

decreased thymocyte number ( J:141917 )

• the total number of thymocytes is reduced by half of wild-type

• the number of single positive T cells in the thymus is lower than in wild-type mice

• however, the number of double positive cells is normal

abnormal T cell differentiation ( J:141917 )

• T cell development is partially blocked after pre-TCR signaling and the DN4 population is reduced compared to in wild-type mice

increased double-negative T cell number ( J:141917 )

• mice exhibit an increase in double negative T cell compared to in wild-type mice up to stage DN4

decreased CD4-positive, alpha-beta T cell number ( J:141917 )

• in the thymus

decreased CD8-positive, alpha-beta T cell number ( J:141917 )

• in the thymus

cellular

increased T cell apoptosis ( J:141917 )

• in culture, the initial number of double positive T cell undergoing apoptosis is greater than for wild-type cells

• however, the rate of apoptosis in vitro is normal

endocrine/exocrine glands

thymus hypoplasia ( J:141917 )

• the total number of thymocytes is reduced by half of wild-type

decreased thymocyte number ( J:141917 )

• the total number of thymocytes is reduced by half of wild-type

• the number of single positive T cells in the thymus is lower than in wild-type mice

• however, the number of double positive cells is normal

Allelic Composition	Nfatc2^tm1Rao/Nfatc2^tm1Rao Nfatc3^tm1Grc/Nfatc3^tm1Grc Tg(Lck-cre)I57Jxm/0
Genetic Background	involves: ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfatc2^tm1Rao mutation (3 available); any Nfatc2 mutation (53 available)
Nfatc3^tm1Grc mutation (0 available); any Nfatc3 mutation (71 available)
Tg(Lck-cre)I57Jxm mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased T cell apoptosis ( J:141917 )

• the rate of T cells undergoing apoptosis in culture is slightly greater than in wild-type and Nfatc3^tm1Grc/Nfatc3^tm1Grc Tg(Lck-cre)I57Jxm mice

• however, the number of T cells initially undergoing apoptosis is normal

abnormal T cell differentiation ( J:141917 )

• T cell development is partially blocked after pre-TCR signaling and the DN4 population is reduced compared to in wild-type mice but is not more severe than in Nfatc3^tm1Grc/Nfatc3^tm1Grc Tg(Lck-cre)I57Jxm mice

abnormal double-negative T cell morphology ( J:141917 )

• mice exhibit an increase in DN1 and subsequently a more severe decrease in the number of DN4 T cells compared to in wild-type, Nfactc3 null or Nfact2 null mice

hematopoietic system

increased T cell apoptosis ( J:141917 )

• the rate of T cells undergoing apoptosis in culture is slightly greater than in wild-type and Nfatc3^tm1Grc/Nfatc3^tm1Grc Tg(Lck-cre)I57Jxm mice

• however, the number of T cells initially undergoing apoptosis is normal

abnormal T cell differentiation ( J:141917 )

abnormal double-negative T cell morphology ( J:141917 )

• mice exhibit an increase in DN1 and subsequently a more severe decrease in the number of DN4 T cells compared to in wild-type, Nfactc3 null or Nfact2 null mice

cellular

increased T cell apoptosis ( J:141917 )

• the rate of T cells undergoing apoptosis in culture is slightly greater than in wild-type and Nfatc3^tm1Grc/Nfatc3^tm1Grc Tg(Lck-cre)I57Jxm mice

• however, the number of T cells initially undergoing apoptosis is normal

Allelic Composition	Relb^tm1.1Fwei/Relb^tm1.1Fwei Tg(Lck-cre)I57Jxm/0
Genetic Background	involves: ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Relb^tm1.1Fwei mutation (0 available); any Relb mutation (33 available)
Tg(Lck-cre)I57Jxm mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal gamma-delta T cell morphology ( J:169863 )

• reduced IL17-expressing splenic gamma-delta T cells and Vgamma4 gamma-delta T cells

immune system

immune system phenotype ( J:169863 )

N	• alpha-beta Th17 cell differentiation is normal

abnormal gamma-delta T cell morphology ( J:169863 )

• reduced IL17-expressing splenic gamma-delta T cells and Vgamma4 gamma-delta T cells

decreased interleukin-17 secretion ( J:169863 )

• in the peritoneal cavity of E. coli-infected mice

• in TCRbeta+CD4+CD44^hi thymocytes

increased susceptibility to bacterial infection ( J:169863 )

• mice infected with E. coli exhibit reduced peritoneal neutrophils and IL17 in the peritoneal cavity compared with control mice

Allelic Composition	Rela^tm1Rsch/Rela^tm1Rsch Tg(Lck-cre)I57Jxm/0
Genetic Background	involves: ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rela^tm1Rsch mutation (0 available); any Rela mutation (28 available)
Tg(Lck-cre)I57Jxm mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal gamma-delta T cell morphology ( J:169863 )

• reduced IL17-expressing splenic gamma-delta T cells and Vgamma4 gamma-delta T cells

immune system

immune system phenotype ( J:169863 )

N	• alpha-beta Th17 cell differentiation is normal

abnormal gamma-delta T cell morphology ( J:169863 )

• reduced IL17-expressing splenic gamma-delta T cells and Vgamma4 gamma-delta T cells

decreased interleukin-17 secretion ( J:169863 )

• in the peritoneal cavity of E. coli-infected mice

• in TCRbeta+CD4+CD44^hi thymocytes

increased susceptibility to bacterial infection ( J:169863 )

• mice infected with E. coli exhibit reduced peritoneal neutrophils and IL17 in the peritoneal cavity compared with control mice

Allelic Composition	Ltbr^tm1Avt/Ltbr^tm1Avt Tg(Lck-cre)I57Jxm/0
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ltbr^tm1Avt mutation (0 available); any Ltbr mutation (47 available)
Tg(Lck-cre)I57Jxm mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:158663 )

N	• susceptibility to Citrobacter rodentium infection is similar to wild-type controls

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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