All Phenotypes Gata1<tm2.1Sho> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gata1^tm2.1Sho
targeted mutation 2.1, Stuart Orkin
MGI:2177587

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gata1^tm2.1Sho/Gata1^tm2.1Sho	involves: 129/Sv * 129S4/SvJae	MGI:3798924
ht2	Gata1^tm2.1Sho/Gata1⁺	involves: 129S4/SvJae * C57BL/6	MGI:4415827
ot3	Gata1^tm2.1Sho/Y	involves: 129S4/SvJae * C57BL/6	MGI:4415826

Allelic Composition	Gata1^tm2.1Sho/Gata1^tm2.1Sho
Genetic Background	involves: 129/Sv * 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata1^tm2.1Sho mutation (0 available); any Gata1 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal hematopoietic system physiology ( J:106670 )

• early megakaryocyte maturation is blocked and proplatelet formation in culture is rare

Allelic Composition	Gata1^tm2.1Sho/Gata1⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata1^tm2.1Sho mutation (0 available); any Gata1 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal megakaryocyte differentiation ( J:41605 )

increased megakaryocyte cell number ( J:41605 )

• large increase in megakaryocytes in hematopoietic tissues, presumably because of mosaicism resulting from random X inactivation

• however, normal numbers of platelets

abnormal megakaryocyte progenitor cell morphology ( J:41605 )

• proliferation of megakaryocyte progenitors is greatly enhanced in fetal livers, presumably because of mosaicism resulting from random X inactivation

cellular

abnormal megakaryocyte differentiation ( J:41605 )

Allelic Composition	Gata1^tm2.1Sho/Y
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata1^tm2.1Sho mutation (0 available); any Gata1 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:41605 )

N	• mutants do not develop anemia and exhibit almost normal viability

abnormal megakaryocyte morphology ( J:41605 )

• megakaryocytes are smaller than normal, have scant cytoplasm and condensed nuclei

abnormal megakaryocyte differentiation ( J:41605 )

• maturation of megakaryocytes is arrested

increased megakaryocyte cell number ( J:41605 )

• 10-fold increase in megakaryocytes in the spleen and bone marrow

• excess of abnormal megakaryocytes in the yolk sac and early fetal liver

abnormal megakaryocyte progenitor cell morphology ( J:41605 )

• proliferation of megakaryocyte progenitors is greatly enhanced in fetal livers

thrombocytopenia ( J:41605 )

• platelet numbers are reduced to about 15% of normal

increased mean platelet volume ( J:41605 )

cellular

abnormal megakaryocyte differentiation ( J:41605 )

• maturation of megakaryocytes is arrested

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24