All Phenotypes Gata1<tm2.1Sho> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gata1^tm2.1Sho
targeted mutation 2.1, Stuart Orkin
MGI:2177587

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gata1^tm2.1Sho/Gata1^tm2.1Sho	involves: 129/Sv * 129S4/SvJae	MGI:3798924
ht2	Gata1^tm2.1Sho/Gata1⁺	involves: 129S4/SvJae * C57BL/6	MGI:4415827
ot3	Gata1^tm2.1Sho/Y	involves: 129S4/SvJae * C57BL/6	MGI:4415826

Allelic Composition	Gata1^tm2.1Sho/Gata1^tm2.1Sho
Genetic Background	involves: 129/Sv * 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata1^tm2.1Sho mutation (0 available); any Gata1 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal hematopoietic system physiology ( J:106670 )

• early megakaryocyte maturation is blocked and proplatelet formation in culture is rare

Allelic Composition	Gata1^tm2.1Sho/Gata1⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata1^tm2.1Sho mutation (0 available); any Gata1 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal megakaryocyte differentiation ( J:41605 )

increased megakaryocyte cell number ( J:41605 )

• large increase in megakaryocytes in hematopoietic tissues, presumably because of mosaicism resulting from random X inactivation

• however, normal numbers of platelets

abnormal megakaryocyte progenitor cell morphology ( J:41605 )

• proliferation of megakaryocyte progenitors is greatly enhanced in fetal livers, presumably because of mosaicism resulting from random X inactivation

cellular

abnormal megakaryocyte differentiation ( J:41605 )

Allelic Composition	Gata1^tm2.1Sho/Y
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata1^tm2.1Sho mutation (0 available); any Gata1 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:41605 )

N	• mutants do not develop anemia and exhibit almost normal viability

abnormal megakaryocyte morphology ( J:41605 )

• megakaryocytes are smaller than normal, have scant cytoplasm and condensed nuclei

abnormal megakaryocyte differentiation ( J:41605 )

• maturation of megakaryocytes is arrested

increased megakaryocyte cell number ( J:41605 )

• 10-fold increase in megakaryocytes in the spleen and bone marrow

• excess of abnormal megakaryocytes in the yolk sac and early fetal liver

abnormal megakaryocyte progenitor cell morphology ( J:41605 )

• proliferation of megakaryocyte progenitors is greatly enhanced in fetal livers

thrombocytopenia ( J:41605 )

• platelet numbers are reduced to about 15% of normal

increased mean platelet volume ( J:41605 )

cellular

abnormal megakaryocyte differentiation ( J:41605 )

• maturation of megakaryocytes is arrested

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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