Phenotypes associated with this allele

• Allele Symbol: Gabra1^tm1Rmck
• Allele Name: targeted mutation 1, Ruth M McKernan
• Allele ID: MGI:2177611
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gabra1^tm1Rmck/Gabra1^tm1Rmck	involves: 129S7/SvEvBrd * BALB/c * C57BL/6	MGI:3832491

Genotype
MGI:3832491

hm1

• Allelic Composition: Gabra1^tm1Rmck/Gabra1^tm1Rmck
• Genetic Background: involves: 129S7/SvEvBrd * BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal behavioral response to xenobiotic ( J:62214 )

• diazepam-treated mice fail to exhibit impaired balance and coordination due to sedative effects as do similarly treated wild-type mice

• however, mice exhibit a normal myorelaxant response to diazepam

• locomotor activity is increased in diazepam-treated mice compared to in similarly treated wild-type mice