Phenotypes associated with this allele

• Allele Symbol: Gabra1^tm1Twr
• Allele Name: targeted mutation 1, Thomas W Rosahl
• Allele ID: MGI:2177612
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gabra1^tm1Twr/Gabra1^tm1Twr	involves: 129S7/SvEvBrd * C57BL/6	MGI:3832432

Genotype
MGI:3832432

hm1

• Allelic Composition: Gabra1^tm1Twr/Gabra1^tm1Twr
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:69290 )

• fewer than expected mice survive birth

• however, lethality decreases in subsequent generations

reproductive system

decreased litter size ( J:69290 )

• mice produce smaller than normal litters

• however, litter size increases in subsequent generations

nervous system

abnormal GABA-mediated receptor currents ( J:69290 )

• 23 of 52 Purkinje neurons fail to respond to 1mM GABA unlike wild-type cells while the rest exhibit decreased current amplitudes compared to wild-type cells

• Purkinje cells exhibit reduced potentiation following treatment with zolpidem compared to wild-type mice

• however, potentiation induced by chlorodiazepoxide is normal

behavior/neurological

behavior/neurological phenotype ( J:69290 )

N • mice exhibit normal locomotion, coordination, balance and habituation

poor grooming ( J:69290 )

• mice are less well groomed prior to weaning

• however, grooming improves with age

tremors ( J:69290 )

• when mice are handled

homeostasis/metabolism

abnormal physiological response to xenobiotic ( J:69290 )

• Purkinje cells exhibit reduced potentiation following treatment with zolpidem compared to wild-type mice

• however, potentiation induced by chlorodiazepoxide is normal

growth/size/body

decreased body weight ( J:69290 )

• prior to weaning but improves with age