Phenotypes associated with this allele

• Allele Symbol: Gabrb2^tm1Twr
• Allele Name: targeted mutation 1, Thomas W Rosahl
• Allele ID: MGI:2177613
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gabrb2^tm1Twr/Gabrb2^tm1Twr	involves: 129S7/SvEvBrd * C57BL/6	MGI:3832434

Genotype
MGI:3832434

hm1

• Allelic Composition: Gabrb2^tm1Twr/Gabrb2^tm1Twr
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal GABA-mediated receptor currents ( J:69290 )

• the mean current amplitude of the response to GABA in Purkinje cells is decreased compared to in wild-type cells

behavior/neurological

increased exploration in new environment ( J:69290 )

• mice exhibit increased activity in a new environment

• however, mice habituate normally

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:69290 )

N • potentiation induced by chlorodiazepoxide, zolpidem, loreclezole, etomidate, or pentobarbital in Purkinje neurons is normal