Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tg(Camk2a-cre)1Lfr transgene insertion 1, Louis F Reichardt MGI:2177631 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• seizure threshold measured by ECT test in this conditional null shows an increase in both males and females
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• seizure threshold measured by ECT test in this conditional null shows an increase in both males and females
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at 5-6 months of age, preceded by 1-2 weeks of rapid physical deterioration
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• degeneration of cortical organization in neocortex
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• neuronal apoptosis in neocortex and hippocampus; progressive with age
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• resipratory chain dysfunction in neurons of the neocortex and hippocampus
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• compression occurs
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• severe compression of layers II/III and layer V of the visual cortex
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• mice exhibit a loss of Pou3f1-expressing neurons
• neuron cell bodies exhibit a 27% reduction in size with round morphology
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• dendrites are thin and exhibit reduced complexity
• primary dendrites possess fewer and/or shorter branches
• the average apical diameter of a dendrite is reduced by 41% compared to in heterozygotes
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• mice exhibit a loss of Pou3f1-expressing neurons
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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