Phenotypes associated with this allele

• Allele Symbol: Tg(Myhca-cre)1Lrsn
• Allele Name: transgene insertion 1, Nils-Goran Larsson
• Allele ID: MGI:2177636
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Atp2a2^tm1.1Iemr/Atp2a2^tm1.1Iemr Tg(Myhca-cre)1Lrsn/0	involves: 129P2/OlaHsd * C57BL/6Crl * FVB	MGI:4415178
cn2	Tfam^tm1Lrsn/Tfam^tm1Lrsn Tg(Myhca-cre)1Lrsn/0	involves: 129S1/Sv * 129X1/SvJ * FVB	MGI:2177637

Genotype
MGI:4415178

cn1

• Allelic Composition: Atp2a2^tm1.1Iemr/Atp2a2^tm1.1Iemr; Tg(Myhca-cre)1Lrsn/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6Crl * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:155628 )

• although alive at E10.5, embryos die by E11.5

Genotype
MGI:2177637

cn2

• Allelic Composition: Tfam^tm1Lrsn/Tfam^tm1Lrsn; Tg(Myhca-cre)1Lrsn/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

mortality/aging

premature death ( J:61372 )

• animals surviving past neonatal stage survive for several months; variable penetrance speculated to be the result of a modifying gene

neonatal lethality, incomplete penetrance ( J:61372 )

• 75% of animals die as neonates

cardiovascular system

dilated heart atrium ( J:61372 )

increased heart weight ( J:61372 )

dilated heart left ventricle ( J:61372 )

dilated heart right ventricle ( J:61372 )

cellular

abnormal respiratory electron transport chain ( J:61372 )

• respiratory chain dysfunction in heart; variable penetrance speculated to be the result of a modifying gene

growth/size/body

increased heart weight ( J:61372 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Kearns-Sayre syndrome		DOID:12934	OMIM:530000	J:61372