All Phenotypes Fus<tm1(DDIT3)Dron> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fus^{tm1(DDIT3)Dron}/Fus^{tm1(DDIT3)Dron}	129S6/SvEvTac-Fus^{tm1(DDIT3)Dron}	MGI:2662388
hm2	Fus^{tm1(DDIT3)Dron}/Fus^{tm1(DDIT3)Dron}	involves: 129S6/SvEvTac * CD-1	MGI:2177657

Allelic Composition	Fus^{tm1(DDIT3)Dron}/Fus^{tm1(DDIT3)Dron}
Genetic Background	129S6/SvEvTac-Fus^{tm1(DDIT3)Dron}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fus^{tm1(DDIT3)Dron} mutation (0 available); any Fus mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:60224 )

• none survive to adulthood on a 129S6/SvEv genetic background

postnatal lethality, incomplete penetrance ( J:60224 )

• while some mice are alive at weaning, none survive to adulthood on a 129S6/SvEv genetic background

• Background Sensitivity: viability is unimpaired on a genetic background involving approximately equal contributions from the 129S6/SvEv and CD1 backgrounds

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased mortality induced by gamma-irradiation ( J:60224 )

endocrine/exocrine glands

small testis ( J:60224 )

• progressive reduction in size resulting in adult testes two-thirds to half the size of those of wild-type

• selective reduction in the volume of seminiferous epithelium

growth/size/body

decreased body size ( J:60224 )

• both males and females are ~70% the size of wild-type littermates at 3 weeks of age

decreased body weight ( J:60224 )

postnatal growth retardation ( J:60224 )

reproductive system

abnormal male meiosis ( J:60224 )

• asynapsis observed 17.6% of pachytene nuclei

• non-homologous synapsis observed in 3.9% of pachytene nuclei

• increased apoptosis of pachytene spermatocytes

• some progression through meiosis in spite of partial asynapsis

• enlarged round spermatids

small testis ( J:60224 )

• progressive reduction in size resulting in adult testes two-thirds to half the size of those of wild-type

• selective reduction in the volume of seminiferous epithelium

reduced female fertility ( J:60224 )

• litters produce by mutant females were approximately half the size of those birthed by wild-type females

decreased litter size ( J:60224 )

male infertility ( J:60224 )

• males are infertile; however, serum testosterone levels are normal

homeostasis/metabolism