homeostasis/metabolism
• slight increase in blood glucose concentration (165 mg/dl vs. 132 mg/dl in wild-type)
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Allele Symbol Allele Name Allele ID |
Gcktm1.1Mgn targeted mutation 1.1, Mark A Magnuson MGI:2177709 |
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Summary |
5 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• slight increase in blood glucose concentration (165 mg/dl vs. 132 mg/dl in wild-type)
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• about 10% increase in blood glucose concentration (194 mg/dl vs. 175 mg/dl in wild-type)
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• more than 80% neonatal mortality as a result of severe hyperglycemia
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• highly variable but increased blood glucose concentrations
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• decreased by about 70%
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• diminished hepatic glycogen
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• diminished hepatic glycogen
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
maturity-onset diabetes of the young type 2 | DOID:0111100 |
OMIM:125851 |
J:51826 |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• 70% decrease in insulin secretion during hyperglycemic clamp studies
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• blood glucose concentration is increased by about 50% compared to heterozygous Gcktm1.1Mgn mice
• under fasting conditions, have a 25% increase in blood glucose concentration, without differences in basal insulin concentration
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• glucose turnover and glucose infusion rates during hyperglycemic clamp are reduced by about 60 and 70%, respectively
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• net glycogen synthesis in liver is reduced by about 50% during hyperglycemic clamp studies
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• 70% decrease in insulin secretion during hyperglycemic clamp studies
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
maturity-onset diabetes of the young type 2 | DOID:0111100 |
OMIM:125851 |
J:51826 |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• secrete 70% less insulin in response to glucose stimulus
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• 10% increase in fed blood glucose concentration
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• post-absorptive (fed) plasma insulin concentrations twice that of controls
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• glucose turnover and glucose infusion rates during hyperglycemic clamp are reduced
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• net hepatic glycogen synthesis is reduced by about 90% during hyperglycemic clamp studies
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• mild insulin resistance
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• secrete 70% less insulin in response to glucose stimulus
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
maturity-onset diabetes of the young type 2 | DOID:0111100 |
OMIM:125851 |
J:51826 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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