Phenotypes associated with this allele

• Allele Symbol: Gck^tm1.2Mgn
• Allele Name: targeted mutation 1.2, Mark A Magnuson
• Allele ID: MGI:2177710
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gck^tm1.2Mgn/Gck^tm1.2Mgn	involves: 129S6/SvEvTac * C57BL/6	MGI:3590685
ht2	Gck^tm1.2Mgn/Gck^+	involves: 129S6/SvEvTac * C57BL/6	MGI:3590686

Genotype
MGI:3590685

hm1

• Allelic Composition: Gck^tm1.2Mgn/Gck^tm1.2Mgn
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:51826 )

• die within 4 days of birth from severe diabetes

homeostasis/metabolism

hyperglycemia ( J:51826 )

• plasma glucose concentration of 566 mg/dl compared to 73 mg/dl in wild-type, at 2 days of age

decreased circulating insulin level ( J:51826 )

• reduced by approximately 70%

increased circulating free fatty acids level ( J:51826 )

• about 1.8-fold increase

decreased liver glycogen level ( J:51826 )

• diminished hepatic glycogen

liver/biliary system

decreased liver glycogen level ( J:51826 )

• diminished hepatic glycogen

hepatic steatosis ( J:51826 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
maturity-onset diabetes of the young type 2		DOID:0111100	OMIM:125851	J:51826

Genotype
MGI:3590686

ht2

• Allelic Composition: Gck^tm1.2Mgn/Gck⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

homeostasis/metabolism

decreased insulin secretion ( J:51826 )

• insulin secretion in response to the hyperglycemic clamp is decreased by 60%

hyperglycemia ( J:51826 )

• plasma glucose concentration increases over time (117 mg/dl vs. 73 mg/dl in wild-type at 2 days and 304 mg/dl vs. 175 mg/dl in wild-type at 6-10 weeks of age)

impaired glucose tolerance ( J:51826 )

• 70% reduction in glucose infusion rate in hyperglycemic clamp studies

decreased liver glycogen level ( J:51826 )

• intermediate levels of hepatic glycogen under normal conditions

• hepatic glycogen synthesis is decreased by more than 90% in response to the hyperglycemic clamp

liver/biliary system

decreased liver glycogen level ( J:51826 )

• intermediate levels of hepatic glycogen under normal conditions

• hepatic glycogen synthesis is decreased by more than 90% in response to the hyperglycemic clamp

hepatic steatosis ( J:51826 )

• intermediate amount of steatosis

endocrine/exocrine glands

decreased insulin secretion ( J:51826 )

• insulin secretion in response to the hyperglycemic clamp is decreased by 60%

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
maturity-onset diabetes of the young type 2		DOID:0111100	OMIM:125851	J:51826