All Phenotypes Tg(Camk2a-cre)1Szi MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Camk2a-cre)1Szi
transgene insertion 1, Scott Zeitlin
MGI:2177768

Summary

8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ercc6^tm1Gvh/Ercc6^tm1Gvh Xpa^tm1Gvh/Xpa^tm1Hvs Tg(Camk2a-cre)1Szi/0	involves: 129P2/OlaHsd * C57BL/6J * CBA	MGI:5312300
cn2	Htt^tm1Szi/Htt^tm2Szi Tg(Camk2a-cre)1Szi/0	involves: 129S/SvEv * 129S1/Sv * C57BL/6 * CBA	MGI:3605769
cn3	Bdnf^tm1Sieg/Bdnf^tm1Sieg Tg(Camk2a-cre)1Szi/0	involves: 129S/SvEv * C57BL/6 * CBA	MGI:2678292
cn4	Rap1a^tm1Morz/Rap1a^tm1Morz Rap1b^tm1Morz/Rap1b^tm1Morz Tg(Camk2a-cre)1Szi/?	involves: 129S/SvEv * C57BL/6J * CBA	MGI:3777607
cn5	Adora2a^tm1Dyj/Adora2a^tm1Dyj Tg(Camk2a-cre)1Szi/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	MGI:3625435
cn6	Adora2a^tm1Dyj/Adora2a^tm1.1Dyj Tg(Camk2a-cre)1Szi/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	MGI:3625463
cn7	Hif1a^tm3Rsjo/Hif1a^tm3Rsjo Tg(Camk2a-cre)1Szi/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	MGI:4418498
cn8	Oxtr^tm1.1Wsy/Oxtr^tm1.1Wsy Tg(Camk2a-cre)1Szi/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL	MGI:3801098

Allelic Composition	Ercc6^tm1Gvh/Ercc6^tm1Gvh Xpa^tm1Gvh/Xpa^tm1Hvs Tg(Camk2a-cre)1Szi/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ercc6^tm1Gvh mutation (1 available); any Ercc6 mutation (78 available)
Tg(Camk2a-cre)1Szi mutation (0 available)
Xpa^tm1Gvh mutation (0 available); any Xpa mutation (21 available)
Xpa^tm1Hvs mutation (3 available); any Xpa mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Dilated ventricles and brain atrophy in Ercc6^tm1Gvh/Ercc6^tm1Gvh Xpa^tm1Gvh/Xpa^tm1Hvs Tg(Camk2a-cre)1Szi/0 mice

mortality/aging

premature death ( J:179808 )

• between 12 and 22 months

nervous system

seizures ( J:179808 )

• from 9 to 12 months of age, mice exhibit seizure behavior characterized by episodes of immobility unlike control mice

microgliosis ( J:179808 )

abnormal telencephalon morphology ( J:179808 )

• at 6 to 12 months of age, mice exhibit atrophy in the telencephalon (cortex, hippocampus, caudate-putamen and septum) unlike control mice

dilated lateral ventricle ( J:179808 )

• at 65 weeks

abnormal dorsal striatum morphology ( J:179808 )

• atrophic at 6 to 12 months of age

hippocampus atrophy ( J:179808 )

• atrophic at 6 to 12 months of age

abnormal cerebral cortex morphology ( J:179808 )

• mild atrophy at 6 months of age

• severe atrophy in older mice

abnormal neocortex morphology ( J:179808 )

• atrophic at 65 weeks

thin cerebral cortex ( J:179808 )

• at 6 to 12 months of age

astrocytosis ( J:179808 )

neuron degeneration ( J:179808 )

behavior/neurological

increased thigmotaxis ( J:179808 )

impaired coordination ( J:179808 )

• at 12 months of age

seizures ( J:179808 )

• from 9 to 12 months of age, mice exhibit seizure behavior characterized by episodes of immobility unlike control mice

growth/size/body

decreased body size ( J:179808 )

• at 9 to 12 months of age

decreased body weight ( J:179808 )

• at 9 to 12 months of age

immune system

microgliosis ( J:179808 )

hematopoietic system

microgliosis ( J:179808 )

Allelic Composition	Htt^tm1Szi/Htt^tm2Szi Tg(Camk2a-cre)1Szi/0
Genetic Background	involves: 129S/SvEv * 129S1/Sv * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htt^tm1Szi mutation (0 available); any Htt mutation (178 available)
Htt^tm2Szi mutation (0 available); any Htt mutation (178 available)
Tg(Camk2a-cre)1Szi mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:65520 )

• die between 11 and 13 months of age

growth/size/body

decreased body size ( J:65520 )

• smaller than controls at weaning and at P60

behavior/neurological

limb grasping ( J:65520 )

• abnormal limb clasping at P60 that becomes progressively more severe such that mice curl their body upon clasping and maintain the posture for several seconds following return to cage

tremors ( J:65520 )

• exhibit a slight tremor at 10-12 months of age

impaired coordination ( J:65520 )

• exhibit motor defects in mutants subjected to cage-top rotation test and elevated wire rod hanging test

decreased locomotor activity ( J:65520 )

• noticeably hypoactive at 10-12 months of age

nervous system

gliosis ( J:65520 )

• gliosis is seen throughout the forebrain in older mutants

astrocytosis ( J:65520 )

• reactive astocytosis in the entorhinal cortex, striatum, and frontal cortex at 4 and 10 months of age

neurodegeneration ( J:65520 )

• 4 and 8 month old mutants exhibit neurodegeneration in the external capsule fibre tracts and in fibre bundles of the internal capsule within the striatum, in the amygdala and in both the frontal and dorsal cortex

reproductive system

oligozoospermia ( J:65520 )

• exhibit a reduction in the number of spermatocytes and round spermatids in the seminiferous tubules and in mature motile sperm in the lumen of the epididymis

abnormal seminiferous tubule morphology ( J:65520 )

• disorganized and contain fewer spermatocytes and round spermatids compared to controls

small testis ( J:65520 )

• testis is about 50% the weight of controls

reduced male fertility ( J:65520 )

endocrine/exocrine glands

abnormal seminiferous tubule morphology ( J:65520 )

• disorganized and contain fewer spermatocytes and round spermatids compared to controls

small testis ( J:65520 )

• testis is about 50% the weight of controls

cellular

oligozoospermia ( J:65520 )

• exhibit a reduction in the number of spermatocytes and round spermatids in the seminiferous tubules and in mature motile sperm in the lumen of the epididymis

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Huntington's disease		DOID:12858	OMIM:143100	J:65520

Allelic Composition	Bdnf^tm1Sieg/Bdnf^tm1Sieg Tg(Camk2a-cre)1Szi/0
Genetic Background	involves: 129S/SvEv * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnf^tm1Sieg mutation (0 available); any Bdnf mutation (42 available)
Tg(Camk2a-cre)1Szi mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

reduced long-term potentiation ( J:85602 )

• significant decrease in the magnitude of LTP induced by 200 Hz tetanic stimulation, such that the mean field EPSP measured 1 hour after induction of LTP is enhanced to only 145% of its pretetanus level in mutants compared to 198% enhancement in controls

• the enhancement of FM 1-43 (a fluorescent marker of synaptic vesicle cycling) release from presynaptic terminals seen in controls during high-frequency (200 Hz) tetanic stimulation is blocked in mutants; rate of FM 1-43 release during low-frequency (50 Hz) tetanic stimulation is normal

• mutants exhibit a smaller magnitude of LTP 1 hour following theta burst stimulation, with an enhancement in the fEPSP to 136.7% of it's initial value compared to 166% in controls

Allelic Composition	Rap1a^tm1Morz/Rap1a^tm1Morz Rap1b^tm1Morz/Rap1b^tm1Morz Tg(Camk2a-cre)1Szi/?
Genetic Background	involves: 129S/SvEv * C57BL/6J * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rap1a^tm1Morz mutation (2 available); any Rap1a mutation (25 available)
Rap1b^tm1Morz mutation (2 available); any Rap1b mutation (32 available)
Tg(Camk2a-cre)1Szi mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal nervous system physiology ( J:132855 )

• protein levels of Rap1 are reduced by 89.4% in the cortex and 38.7% in the thalamus

abnormal excitatory postsynaptic potential ( J:132855 )

• synaptic efficacy in cortical but not thalamic input to the lateral amygdale is 2.5-fold higher than in wild-type mice

• current-voltage relationships for AMPAR and NMDAR currents are similar to wild-type mice

reduced long-term potentiation ( J:132855 )

• in the cortico-amygdala pathway, spike-timing-dependent LTP was substantially reduced with only 2 of 7 cells showing a LTP response compared to 8 of 11 cells from wild-type

abnormal synaptic glutamate release ( J:132855 )

• EPSC evoked by minimal stimulation of cortical inputs into the lateral amygdale reveals increased release of glutamate

decreased paired-pulse facilitation ( J:132855 )

• mice do not demonstrate PPF in cortical inputs to the lateral amygdale before or after long-term potentiation

behavior/neurological

abnormal cued conditioning behavior ( J:132855 )

• mice have reduced fear learning as measured by freezing to a conditioned stimulus both 3 hours and 48 hours after training with a moderately adversive unconditioned stimulus

• there is no difference in fear learning compared to wild-type mice when a more severe unconditioned stimulus is used in training

Allelic Composition	Adora2a^tm1Dyj/Adora2a^tm1Dyj Tg(Camk2a-cre)1Szi/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adora2a^tm1Dyj mutation (1 available); any Adora2a mutation (40 available)
Tg(Camk2a-cre)1Szi mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal locomotor activation ( J:104338 )

• in response to the adenosine (A2a) agonist KW-6002, locomotion is induced in male control animals but not in conditional knockout mice

• enhancement of fine movement behavior in controls is observed in response to amphetamine treatment but not in knockouts

Allelic Composition	Adora2a^tm1Dyj/Adora2a^tm1.1Dyj Tg(Camk2a-cre)1Szi/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adora2a^tm1.1Dyj mutation (0 available); any Adora2a mutation (40 available)
Adora2a^tm1Dyj mutation (1 available); any Adora2a mutation (40 available)
Tg(Camk2a-cre)1Szi mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

impaired behavioral response to addictive substance ( J:104338 )

• daily treatment with amphetamine enhances locomotor responses in male control mice but does not affect male mutants; 1 week after cessation of treatment robust locomotor sensitization persists in controls

abnormal locomotor activation ( J:102700 , J:104338 )

• control mice exhibit greater locomotor response when treated with a Grm5 antagonist, MPEP, than forebrain-specific knockout mice (J:102700)

• in response to the adenosine (A2a) agonist KW-6002, locomotion is induced in male control animals but not in conditional knockout mice (J:104338)

• enhancement of fine movement behavior in male controls is observed in response to amphetamine treatment but not in knockouts (J:104338)

Allelic Composition	Hif1a^tm3Rsjo/Hif1a^tm3Rsjo Tg(Camk2a-cre)1Szi/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hif1a^tm3Rsjo mutation (3 available); any Hif1a mutation (50 available)
Tg(Camk2a-cre)1Szi mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:121971 )

• following transient middle cerebral artery occlusion

nervous system

abnormal brain vasculature morphology ( J:121971 )

• mice exhibit a slight reduction in cerebral cortex microvascular density compared with Hif1a^tm3Rsjo homozygotes

decreased susceptibility to ischemic brain injury ( J:121971 )

• following bilateral common carotid artery occlusion, mice exhibit decreased neuronal damage compared to in similarly treated Hif1a^tm3Rsjo homozygotes

increased susceptibility to ischemic brain injury ( J:121971 )

• following transient middle cerebral artery occlusion, mice exhibit increased infarct size, increased neurological deficit scores, and mortality compared with similarly treated Hif1a^tm3Rsjo homozygotes

increased cerebral infarct size ( J:121971 )

• 4 days after transient middle cerebral artery occlusion, infarct size is larger than in similarly treated Hif1a^tm3Rsjo homozygotes

• the neuroprotective effects on infarct size and neurological deficit scores of 3,4-dihydroxybenzoic acid, deferoxamine (DFO), and DP following transient middle cerebral artery occlusion is decreased compared to in similarly treated Hif1a^tm3Rsjo homozygotes

• however, mice still respond to neuroprotective hypoxia with reduced infarct volume at shorter exposure periods than wild-type mice

hydrocephaly ( J:121971 )

• uncommon

homeostasis/metabolism

abnormal physiological response to xenobiotic ( J:121971 )

decreased susceptibility to ischemic brain injury ( J:121971 )

• following bilateral common carotid artery occlusion, mice exhibit decreased neuronal damage compared to in similarly treated Hif1a^tm3Rsjo homozygotes

increased susceptibility to ischemic brain injury ( J:121971 )

increased cerebral infarct size ( J:121971 )

• 4 days after transient middle cerebral artery occlusion, infarct size is larger than in similarly treated Hif1a^tm3Rsjo homozygotes

• however, mice still respond to neuroprotective hypoxia with reduced infarct volume at shorter exposure periods than wild-type mice

behavior/neurological

abnormal behavior ( J:121971 )

• following transient middle cerebral artery occlusion, mice exhibit increased neurological deficit scores compared with similarly treated Hif1a^tm3Rsjo homozygotes

cardiovascular system

abnormal brain vasculature morphology ( J:121971 )

• mice exhibit a slight reduction in cerebral cortex microvascular density compared with Hif1a^tm3Rsjo homozygotes

Allelic Composition	Oxtr^tm1.1Wsy/Oxtr^tm1.1Wsy Tg(Camk2a-cre)1Szi/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Oxtr^tm1.1Wsy mutation (1 available); any Oxtr mutation (41 available)
Tg(Camk2a-cre)1Szi mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:137445 )

• weigh less than control mice

• weight discrepancy relative to controls increases with age

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:137445 )

N	• normal milk production

behavior/neurological

abnormal social investigation ( J:137445 )

• less time spend by males investigating either familiar or novel females during second trials

• 5-trial recognition studies indicated no difference between mutant mice and controls

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