Phenotypes associated with this allele

• Allele Symbol: Srebf1^tm1Jdh
• Allele Name: targeted mutation 1, Jay D Horton
• Allele ID: MGI:2177773
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Srebf1^tm1Jdh/Srebf1^tm1Jdh	involves: 129S/SvEvBrd * C57BL/6	MGI:3801600

Genotype
MGI:3801600

hm1

• Allelic Composition: Srebf1^tm1Jdh/Srebf1^tm1Jdh
• Genetic Background: involves: 129S/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:43570 )

• only 14% of expected mice survive to adulthood

lethality throughout fetal growth and development, incomplete penetrance ( J:43570 )

• despite normal appearance at E10.5, most mice die between E11.5 and E14.5

embryonic lethality during organogenesis, incomplete penetrance ( J:43570 )

• despite normal appearance at E10.5, most mice die between E11.5 and E14.5

homeostasis/metabolism

increased liver cholesterol level ( J:43570 )

• 1.5-fold

liver/biliary system

increased liver cholesterol level ( J:43570 )

• 1.5-fold