All Phenotypes Lif<tm1Stw> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Lif^tm1Stw
targeted mutation 1, Colin L Stewart
MGI:2177780

Summary

15 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lif^tm1Stw/Lif^tm1Stw	involves: 129S1/Sv	MGI:4834679
hm2	Lif^tm1Stw/Lif^tm1Stw	involves: 129S1/Sv * BALB/c	MGI:4834898
hm3	Lif^tm1Stw/Lif^tm1Stw	involves: 129S1/Sv * BALB/c * C57BL/6J	MGI:4834782
hm4	Lif^tm1Stw/Lif^tm1Stw	involves: 129S1/Sv * C57BL/6	MGI:4834753
hm5	Lif^tm1Stw/Lif^tm1Stw	involves: 129S1/Sv * C57BL/6 * MF1	MGI:4834890
hm6	Lif^tm1Stw/Lif^tm1Stw	involves: 129S1/Sv * C57BL/6J	MGI:2177781
hm7	Lif^tm1Stw/Lif^tm1Stw	involves: 129S1/Sv * MF1	MGI:4834997
cx8	Igf1^tm1Arge/Igf1⁺ Lif^tm1Stw/Lif^tm1Stw	involves: 129S/SvEv * 129S1/Sv	MGI:4834804
cx9	Igf1^tm1Arge/Igf1^tm1Arge Lif^tm1Stw/Lif^tm1Stw	involves: 129S/SvEv * 129S1/Sv	MGI:4834806
cx10	Igf1^tm1Arge/Igf1⁺ Lif^tm1Stw/Lif^tm1Stw	involves: 129S/SvEv * 129S1/Sv * BALB/c * C57BL/6J * MF1	MGI:4834783
cx11	Igf1^tm1Arge/Igf1^tm1Arge Lif^tm1Stw/Lif⁺	involves: 129S/SvEv * 129S1/Sv * BALB/c * C57BL/6J * MF1	MGI:4834785
cx12	Igf1^tm1Arge/Igf1^tm1Arge Lif^tm1Stw/Lif^tm1Stw	involves: 129S/SvEv * 129S1/Sv * BALB/c * C57BL/6J * MF1	MGI:4834786
cx13	Igf1^tm1Arge/Igf1⁺ Lif^tm1Stw/Lif^tm1Stw	involves: 129S/SvEv * 129S1/Sv * C57BL/6 * MF1	MGI:4834891
cx14	Igf1^tm1Arge/Igf1⁺ Lif^tm1Stw/Lif⁺	involves: 129S/SvEv * 129S1/Sv * C57BL/6 * MF1	MGI:4834892
cx15	Il6^tm1Kopf/Il6^tm1Kopf Lif^tm1Stw/Lif^tm1Stw	involves: 129S1/Sv * 129S2/SvPas * C57BL/6	MGI:4834760

Allelic Composition	Lif^tm1Stw/Lif^tm1Stw
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lif^tm1Stw mutation (1 available); any Lif mutation (11 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal mammary gland growth during pregnancy ( J:83804 )

• mice exhibit precocious alveolar development during early pregnancy compared with wild-type mice

• as early as 4 weeks during pregnancy, ductal elongation is reduced and ducts are thicker than in wild-type mice

• during pregnancy, terminal end buds are more round and disorientated than in wild-type mice

• during pregnancy, the number of alveolar buds is increased 2-fold compared to in wild-type mice

nervous system

decreased motor neuron number ( J:103711 )

• at E18.5, mice exhibit reduced motor neurons in the brainstem nuclei (trigeminal nuclei) compared with wild-type mice

homeostasis/metabolism

decreased circulating adrenocorticotropin level ( J:34269 )

• in unstressed and stressed mice

endocrine/exocrine glands

abnormal involution of the mammary gland ( J:83804 )

• after forced involution, alveoli remain intact and extended with reduced apoptosis compared to in similarly treated wild-type mice

• however, forced involution induces shedding of cells into the lumen

abnormal mammary gland growth during pregnancy ( J:83804 )

• mice exhibit precocious alveolar development during early pregnancy compared with wild-type mice

• as early as 4 weeks during pregnancy, ductal elongation is reduced and ducts are thicker than in wild-type mice

• during pregnancy, terminal end buds are more round and disorientated than in wild-type mice

• during pregnancy, the number of alveolar buds is increased 2-fold compared to in wild-type mice

abnormal mammary gland duct morphology ( J:83804 )

• as early as 4 weeks during pregnancy, ductal elongation is reduced and ducts are thicker than in wild-type mice

abnormal mammary gland alveolus morphology ( J:83804 )

• as early as 4 weeks during pregnancy, ductal elongation is reduced and ducts are thicker than in wild-type mice

• during pregnancy, terminal end buds are more round and disorientated than in wild-type mice

• during pregnancy, the number of alveolar buds is increased 2-fold compared to in wild-type mice

abnormal mammary gland physiology ( J:83804 )

• after forced involution, alveoli remain intact and extended with reduced apoptosis compared to in similarly treated wild-type mice

integument

abnormal involution of the mammary gland ( J:83804 )

• after forced involution, alveoli remain intact and extended with reduced apoptosis compared to in similarly treated wild-type mice

• however, forced involution induces shedding of cells into the lumen

abnormal mammary gland growth during pregnancy ( J:83804 )

• mice exhibit precocious alveolar development during early pregnancy compared with wild-type mice

• as early as 4 weeks during pregnancy, ductal elongation is reduced and ducts are thicker than in wild-type mice

• during pregnancy, terminal end buds are more round and disorientated than in wild-type mice

• during pregnancy, the number of alveolar buds is increased 2-fold compared to in wild-type mice

abnormal mammary gland duct morphology ( J:83804 )

• as early as 4 weeks during pregnancy, ductal elongation is reduced and ducts are thicker than in wild-type mice

abnormal mammary gland alveolus morphology ( J:83804 )

• as early as 4 weeks during pregnancy, ductal elongation is reduced and ducts are thicker than in wild-type mice

• during pregnancy, terminal end buds are more round and disorientated than in wild-type mice

• during pregnancy, the number of alveolar buds is increased 2-fold compared to in wild-type mice

abnormal mammary gland physiology ( J:83804 )

• after forced involution, alveoli remain intact and extended with reduced apoptosis compared to in similarly treated wild-type mice

Allelic Composition	Lif^tm1Stw/Lif^tm1Stw
Genetic Background	involves: 129S1/Sv * BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lif^tm1Stw mutation (1 available); any Lif mutation (11 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:136940 )

• in D-Gal-sensitized mice treated with LPS

immune system

decreased leukocyte cell number ( J:136940 )

• in LPS-treated mice

increased circulating interleukin-6 level ( J:136940 )

• in LPS-treated mice

increased circulating tumor necrosis factor level ( J:136940 )

• in LPS-treated mice

increased circulating serum amyloid protein level ( J:136940 )

• LPS-treated mice exhibit increased serum amyloid A initially and P protein at 24 to 48 hours compared with similarly treated wild-type mice

decreased interleukin-10 secretion ( J:136940 )

• in macrophages from LPS-treated mice

increased susceptibility to endotoxin shock ( J:136940 )

• LPS-treated mice exhibit decreased IL10 secretion by macrophages and increased leukopenia, thrombocytopenia, and serum levels of TNFalpha, IL6, and serum amyloid A and P protein compared with similarly treated wild-type mice

• D-Gal-sensitized mice treated with LPS exhibit increased clinical symptoms of shock (huddled posture, piloerection, shivering, diarrhea, and body weight loss), liver damage (elevated alanine and aspartate transaminase levels, vascular congestion, hemorrhage, hepatocelluar vacuolization, fragmentation, pyknosis, and necrosis), neutrophil recruitment to the lungs, and lethality compared with similarly treated wild-type mice

increased susceptibility to bacterial infection induced morbidity/mortality ( J:136940 )

• in D-Gal-sensitized mice treated with LPS

liver/biliary system

liver vascular congestion ( J:136940 )

• in D-Gal-sensitized mice treated with LPS

liver hemorrhage ( J:136940 )

• in D-Gal-sensitized mice treated with LPS

abnormal hepatocyte morphology ( J:136940 )

• D-Gal-sensitized mice treated with LPS exhibit hepatocelluar vacuolization, fragmentation, and pyknosis compared with similarly treated wild-type mice

hepatic necrosis ( J:136940 )

• in D-Gal-sensitized mice treated with LPS

homeostasis/metabolism

increased circulating interleukin-6 level ( J:136940 )

• in LPS-treated mice

increased circulating tumor necrosis factor level ( J:136940 )

• in LPS-treated mice

increased circulating alanine transaminase level ( J:136940 )

• in D-Gal-sensitized mice treated with LPS

increased circulating aspartate transaminase level ( J:136940 )

• in D-Gal-sensitized mice treated with LPS

increased circulating serum amyloid protein level ( J:136940 )

• LPS-treated mice exhibit increased serum amyloid A initially and P protein at 24 to 48 hours compared with similarly treated wild-type mice

behavior/neurological

abnormal pilomotor reflex ( J:136940 )

• in D-Gal-sensitized mice treated with LPS

tremors ( J:136940 )

• in D-Gal-sensitized mice treated with LPS

growth/size/body

increased susceptibility to weight loss ( J:136940 )

• in D-Gal-sensitized mice treated with LPS

cardiovascular system

liver vascular congestion ( J:136940 )

• in D-Gal-sensitized mice treated with LPS

liver hemorrhage ( J:136940 )

• in D-Gal-sensitized mice treated with LPS

digestive/alimentary system

diarrhea ( J:136940 )

• in D-Gal-sensitized mice treated with LPS

hematopoietic system

thrombocytopenia ( J:136940 )

• in LPS-treated mice

decreased leukocyte cell number ( J:136940 )

• in LPS-treated mice

Allelic Composition	Lif^tm1Stw/Lif^tm1Stw
Genetic Background	involves: 129S1/Sv * BALB/c * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lif^tm1Stw mutation (1 available); any Lif mutation (11 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:82113 )

• more mice die during the postnatal period than expected

skeleton

abnormal skeleton morphology ( J:82113 )

• mice exhibit reduced skeleton size compared with wild-type mice

Allelic Composition	Lif^tm1Stw/Lif^tm1Stw
Genetic Background	involves: 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lif^tm1Stw mutation (1 available); any Lif mutation (11 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:115507 )

N	• brain histology appears normal

abnormal brain vasculature morphology ( J:137720 )

• capillary networks in the hindbrain plexus and fore limb are densely condensed compared to in wild-type mice

abnormal glial cell morphology ( J:89814 )

• 24 hours after scalpel cortex injury, mice exhibit reduced microglial and astrocyte reaction compared with similarly treated wild-type mice

abnormal CNS glial cell morphology ( J:115507 )

• mice exhibit fewer GFAP+ glial cells are detected, especially in the stratum pyramidal, compared with wild-type mice

• however, the number of S100+ glial cells is normal

abnormal astrocyte morphology ( J:137720 )

• mice exhibit fewer GFAP+ astrocytes compared with wild-type mice

• astrocyte proliferation in the retina is increased compared to in wild-type mice until P6 to P8

integument

abnormal skin vasculature morphology ( J:137720 )

• at E11, microvessels in the trunk skin exhibit increased density compared to in wild-type mice

cellular

increased vascular endothelial cell proliferation ( J:137720 )

• endothelial proliferation in the retina is increased compared to in wild-type mice

cardiovascular system

abnormal blood vessel morphology ( J:137720 )

• microvessels in P4 trachea exhibit increased filopodia and branching compared to in wild-type mice

abnormal capillary morphology ( J:137720 )

• capillary networks in the hindbrain plexus and fore limb are densely condensed compared to in wild-type mice

abnormal brain vasculature morphology ( J:137720 )

• capillary networks in the hindbrain plexus and fore limb are densely condensed compared to in wild-type mice

abnormal retina vasculature morphology ( J:137720 )

• retinal vasculature exhibit increased endothelial filopodia and branching points and increased capillary density compared to in wild-type mice

abnormal induced retina neovascularization ( J:137720 )

• in a model of oxygen-induced retinopathy, mice exhibit increased extraretinal neovascularization compared with similarly treated wild-type mice

abnormal skin vasculature morphology ( J:137720 )

• at E11, microvessels in the trunk skin exhibit increased density compared to in wild-type mice

increased vascular endothelial cell proliferation ( J:137720 )

• endothelial proliferation in the retina is increased compared to in wild-type mice

growth/size/body

decreased body size ( J:119777 )

homeostasis/metabolism

increased circulating interleukin-1 beta level ( J:119777 )

• following exposure to complete Freund's adjuvant (CFA), mice exhibit a 9-fold increased in IL1beta compared with a 2-fold increase in similarly treated wild-type mice

decreased susceptibility to injury ( J:89814 , J:137720 )

• 24 hours after nerve crush injury, mice exhibit 3-fold less neutrophils, 1.7-fold less macrophages, and 1.8-fold less mast cells at the site of injury compared with similarly treated wild-type mice (J:89814)

• 24 hours after scalpel cortex injury, mice exhibit reduced microglial and astrocyte reaction compared with similarly treated wild-type mice (J:89814)

• however, mice exhibit normal cell infiltration 7 days after nerve crush injury (J:89814)

• mice are resistant to hyperoxic insult on the retina compared with similarly treated wild-type mice (J:137720)

immune system

increased circulating interleukin-1 beta level ( J:119777 )

• following exposure to complete Freund's adjuvant (CFA), mice exhibit a 9-fold increased in IL1beta compared with a 2-fold increase in similarly treated wild-type mice

increased acute inflammation ( J:119777 )

• following exposure to complete Freund's adjuvant (CFA), mice exhibit increased swelling, IL1beta levels, and neutrophil infiltration (4.8-fold) compared with similarly treated wild-type mice

vision/eye

abnormal retina vasculature morphology ( J:137720 )

• retinal vasculature exhibit increased endothelial filopodia and branching points and increased capillary density compared to in wild-type mice

abnormal induced retina neovascularization ( J:137720 )

• in a model of oxygen-induced retinopathy, mice exhibit increased extraretinal neovascularization compared with similarly treated wild-type mice

Allelic Composition	Lif^tm1Stw/Lif^tm1Stw
Genetic Background	involves: 129S1/Sv * C57BL/6 * MF1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lif^tm1Stw mutation (1 available); any Lif mutation (11 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating insulin-like growth factor I level ( J:87585 )

increased circulating leptin level ( J:87585 )

• in female mice

decreased circulating triglyceride level ( J:87585 )

• in female mice

Allelic Composition	Lif^tm1Stw/Lif^tm1Stw
Genetic Background	involves: 129S1/Sv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lif^tm1Stw mutation (1 available); any Lif mutation (11 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:35071 )

• body weight reduced by 25-35% that of littermates

postnatal growth retardation ( J:35071 )

reproductive system

abnormal uterus morphology ( J:35071 )

• uteri were pale and poorly vascularized

failure of embryo implantation ( J:35071 )

• failed implantation of both endogenous and wild-type blastocysts

female infertility ( J:35071 )

• blastocysts failed to implant

• blastocysts transferred into wild-type pseudopregnant recipients implanted and developed to term

Allelic Composition	Lif^tm1Stw/Lif^tm1Stw
Genetic Background	involves: 129S1/Sv * MF1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lif^tm1Stw mutation (1 available); any Lif mutation (11 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal osteoclast morphology ( J:137646 )

• oteoclast number and size are increased compared to in wild-type mice

abnormal osteoclast differentiation ( J:137646 )

• fetal liver derived osteoclast progenitors fail to differentiate in vitro unlike similarly treated wild-type cells

increased osteoclast cell number ( J:137646 )

abnormal osteoclast physiology ( J:137646 )

• osteoclast progenitors exhibit increased apoptosis compared with wild-type cells

• osteoclasts are hypoxic unlike in wild-type mice

decreased bone volume ( J:137646 )

• in newborn mice, bone volume is decreased compared to in wild-type mice

increased bone resorption ( J:137646 )

homeostasis/metabolism

hypoxia ( J:137646 )

• osteoclasts are hypoxic unlike in wild-type mice

immune system

abnormal osteoclast morphology ( J:137646 )

• oteoclast number and size are increased compared to in wild-type mice

abnormal osteoclast differentiation ( J:137646 )

• fetal liver derived osteoclast progenitors fail to differentiate in vitro unlike similarly treated wild-type cells

increased osteoclast cell number ( J:137646 )

abnormal osteoclast physiology ( J:137646 )

• osteoclast progenitors exhibit increased apoptosis compared with wild-type cells

• osteoclasts are hypoxic unlike in wild-type mice

hematopoietic system

abnormal osteoclast morphology ( J:137646 )

• oteoclast number and size are increased compared to in wild-type mice

abnormal osteoclast differentiation ( J:137646 )

• fetal liver derived osteoclast progenitors fail to differentiate in vitro unlike similarly treated wild-type cells

increased osteoclast cell number ( J:137646 )

abnormal osteoclast physiology ( J:137646 )

• osteoclast progenitors exhibit increased apoptosis compared with wild-type cells

• osteoclasts are hypoxic unlike in wild-type mice

cellular

abnormal osteoclast differentiation ( J:137646 )

• fetal liver derived osteoclast progenitors fail to differentiate in vitro unlike similarly treated wild-type cells

Allelic Composition	Igf1^tm1Arge/Igf1⁺ Lif^tm1Stw/Lif^tm1Stw
Genetic Background	involves: 129S/SvEv * 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1^tm1Arge mutation (2 available); any Igf1 mutation (27 available)
Lif^tm1Stw mutation (1 available); any Lif mutation (11 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased motor neuron number ( J:103711 )

• fewer motor neurons are present in the trigeminal nuclei compared to in wild-type mice

Allelic Composition	Igf1^tm1Arge/Igf1^tm1Arge Lif^tm1Stw/Lif^tm1Stw
Genetic Background	involves: 129S/SvEv * 129S1/Sv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cerebellar Purkinje cell layer ( J:103711 )

• slightly thinner than normal in some mice

decreased motor neuron number ( J:103711 )

• at E18.5, mice exhibit reduced motor neurons in the brainstem nuclei (trigeminal and facial nuclei) compared with wild-type mice and Igf1^tm1Arge homozygotes

Allelic Composition	Igf1^tm1Arge/Igf1⁺ Lif^tm1Stw/Lif^tm1Stw
Genetic Background	involves: 129S/SvEv * 129S1/Sv * BALB/c * C57BL/6J * MF1

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality ( J:82113 )

• more mice die during the postnatal period than expected

Allelic Composition	Igf1^tm1Arge/Igf1^tm1Arge Lif^tm1Stw/Lif⁺
Genetic Background	involves: 129S/SvEv * 129S1/Sv * BALB/c * C57BL/6J * MF1

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality ( J:82113 )

• more mice die during the postnatal period than expected

skeleton

delayed bone ossification ( J:82113 )

• in some mice

Allelic Composition	Igf1^tm1Arge/Igf1^tm1Arge Lif^tm1Stw/Lif^tm1Stw
Genetic Background	involves: 129S/SvEv * 129S1/Sv * BALB/c * C57BL/6J * MF1

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:82113 )

• all mice die at birth

nervous system

abnormal olfactory bulb layer morphology ( J:82113 )

• the boundaries between the glomerular layer, the remaining mitral cell layer, and the granule cell layer are diffuse unlike in wild-type mice

abnormal olfactory bulb external plexiform layer morphology ( J:82113 )

• thin

abnormal olfactory bulb mitral cell layer morphology ( J:82113 )

• at E18.5, the mitral cell layer is reduced and disorganized compared to in wild-type mice

abnormal mitral cell morphology ( J:82113 )

• the number of mitral neurons is decreased compared to in wild-type mice

respiratory system

abnormal lung morphology ( J:82113 )

• lung tissue is more compact than in wild-type mice

abnormal pulmonary alveolus morphology ( J:82113 )

• alveolar spaces are very small compared to in wild-type mice

• very few capillaries are found around narrow alveolar spaces unlike in wild-type mice

absent type I pneumocytes ( J:82113 )

• lungs lack flat putative type I cells

abnormal type II pneumocyte morphology ( J:82113 )

• rounded type II cells exhibit microvilli and cytoplasmic extensions unlike alveoli cells in wild-type mice

increased type II pneumocyte number ( J:82113 )

• more PAS+ type II cells are detected than in wild-type lungs

atelectasis ( J:82113 )

thick pulmonary interalveolar septum ( J:82113 )

skeleton

abnormal skeleton morphology ( J:82113 )

• mice exhibit reduced skeleton size compared with wild-type mice and single homozygotes

abnormal long bone morphology ( J:82113 )

• long bones contain abnormal cells unlike in wild-type mice

decreased bone mineral density ( J:82113 )

delayed bone ossification ( J:82113 )

• in the xyphoid process, sternae, ribs, vertebral column, and cranial bones (the nasal, parietal, interparietal and supraoccipital bones)

• impaired ossification is more evident in the skull than in the long bones

fragile skeleton ( J:82113 )

• 3 of 5 skeletons do not survive the staining process

growth/size/body

decreased body size ( J:82113 )

decreased body weight ( J:82113 )

muscle

muscle hypoplasia ( J:82113 )

integument

underdeveloped hair follicles ( J:82113 )

abnormal keratinocyte morphology ( J:82113 )

• keratinocytes in the basal layer are flattened unlike in wild-type mice

thin epidermis ( J:82113 )

Allelic Composition	Igf1^tm1Arge/Igf1⁺ Lif^tm1Stw/Lif^tm1Stw
Genetic Background	involves: 129S/SvEv * 129S1/Sv * C57BL/6 * MF1

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body mass index ( J:87585 )

• female mice exhibit a lower BMI than wild-type mice

decreased body weight ( J:87585 )

• male and female mice weight less than wild type mice

• female mice weigh less than Lif^tm1Stw homozygotes

slow postnatal weight gain ( J:87585 )

• weight gain in female mice arrests at 6 weeks unlike in wild-type mice

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:87585 )

N	• unlike Lif^tm1Stw homozygotes, female mice exhibit normal circulating triglyceride levels

increased circulating insulin-like growth factor I level ( J:87585 )

increased circulating leptin level ( J:87585 )

• more so in female than male mice

increased growth hormone level ( J:87585 )

• slightly in the pituitary

adipose tissue

abnormal white fat cell morphology ( J:87585 )

• in female mice, white adipose tissue cells are depleted of lipid droplets and more compact than in wild-type mice

• in female mice, white adipose tissue cells are replaced with brown adipose tissue cells

decreased gonadal fat pad weight ( J:87585 )

• in female mice

Allelic Composition	Igf1^tm1Arge/Igf1⁺ Lif^tm1Stw/Lif⁺
Genetic Background	involves: 129S/SvEv * 129S1/Sv * C57BL/6 * MF1

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased growth hormone level ( J:87585 )

• slightly in the pituitary

Allelic Composition	Il6^tm1Kopf/Il6^tm1Kopf Lif^tm1Stw/Lif^tm1Stw
Genetic Background	involves: 129S1/Sv * 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il6^tm1Kopf mutation (9 available); any Il6 mutation (37 available)
Lif^tm1Stw mutation (1 available); any Lif mutation (11 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased susceptibility to injury ( J:89814 )

• 24 hours after scalpel cortex injury, mice exhibit reduced microglial and astrocyte reaction compared with similarly treated wild-type mice but similar to in single homozygotes

nervous system

abnormal glial cell morphology ( J:89814 )

• 24 hours after scalpel cortex injury, mice exhibit reduced microglial and astrocyte reaction compared with similarly treated wild-type mice but similar to in single homozygotes

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