Phenotypes associated with this allele

• Allele Symbol: Kmt2a^tm1Vss
• Allele Name: targeted mutation 1, Vasanta Subramanian
• Allele ID: MGI:2177819
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kmt2a^tm1Vss/Kmt2a^tm1Vss	involves: 129P2/OlaHsd * C57BL/6	MGI:2177872
ht2	Kmt2a^tm1Vss/Kmt2a^+	involves: 129P2/OlaHsd * C57BL/6	MGI:2177873

Genotype
MGI:2177872

hm1

• Allelic Composition: Kmt2a^tm1Vss/Kmt2a^tm1Vss
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:71498 )

• embryos die in very early embryogenesis prior to the two-cell stage

Genotype
MGI:2177873

ht2

• Allelic Composition: Kmt2a^tm1Vss/Kmt2a⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

skeleton

abnormal rib development ( J:71498 )

• uni- or bi-lateral presence of rudimentary ribs on vertebra C7

• rib fusion to sternum

• absence of rib on vertebra T13

abnormal cervical vertebrae morphology ( J:71498 )

• broad and/or split neural arches

abnormal cervical atlas morphology ( J:71498 )

• fusions of C1 and C2

abnormal cervical axis morphology ( J:71498 )

• fusions of C1 and C2

cervical vertebral fusion ( J:71498 )

• fusions of C1 and C2

abnormal vertebral arch morphology ( J:71498 )

• broad and/or split neural arches in the cervical region

vertebral transformation ( J:71498 )

• various vertebral transformations

thoracic vertebral transformation ( J:71498 )

• vertebra T3 or t2 and T3 exhibit a spinous process

• transformations include T13 to L1

lumbar vertebral transformation ( J:71498 )

• vertebral transformations include L6 to S1

nervous system

abnormal cranial ganglia morphology ( J:71498 )

• reduced density of neurofilaments observed at E11.5

abnormal dorsal root ganglion morphology ( J:71498 )

• reduced density of neurofilaments observed at E11.5

• brachial plexus roots are less compacted