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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Capn3tm1Jsb
targeted mutation 1, Jacques S Beckmann
MGI:2177929
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Capn3tm1Jsb/Capn3tm1Jsb either: 129/Sv-Capn3tm1Jsb or (involves: 129/Sv * C57BL/6) MGI:2659043
cx2
 		Capn3tm1Jsb/Capn3+
Ttntm1.1Isrd/Ttn+ 		involves: 129/Sv * 129S2/SvPas * C57BL/6 MGI:4838326
cx3
 		Capn3tm1Jsb/Capn3+
Ttntm1.1Isrd/Ttntm1.1Isrd 		involves: 129/Sv * 129S2/SvPas * C57BL/6 MGI:4838328


Genotype
MGI:2659043
hm1
Allelic
Composition		 Capn3tm1Jsb/Capn3tm1Jsb
Genetic
Background		 either: 129/Sv-Capn3tm1Jsb or (involves: 129/Sv * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Capn3tm1Jsb mutation (0 available); any Capn3 mutation (49 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Dystrophic muscle in Capn3tm1Jsb/Capn3tm1Jsb mice

muscle
abnormal sarcolemma morphology ( J:66862 )
• disruption of sarcolemmal integrity
dystrophic muscle ( J:66862 )
• mutants develop a progressive mild muscular dystrophy
• most severly affects the psoas, soleus, and deltoid muscles
• Background Sensitivity: dystrophic muscle is evident at 2 months of a age in mutants on a 129/Sv background while it becomes evident in mutants on a mixed 129/Sv and C57BL/6 at 6 months of age
• myofibers exhibit an increase in apoptosis

reproductive system
transmission ratio distortion ( J:66862 )
• transmission ratio distortion, preferred transmission of mutant allele

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
autosomal recessive limb-girdle muscular dystrophy type 2A DOID:0110275 OMIM:253600
 J:66862




Genotype
MGI:4838326
cx2
Allelic
Composition		 Capn3tm1Jsb/Capn3+
Ttntm1.1Isrd/Ttn+
Genetic
Background		 involves: 129/Sv * 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Capn3tm1Jsb mutation (0 available); any Capn3 mutation (49 available)
Ttntm1.1Isrd mutation (0 available); any Ttn mutation (1457 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
NOT tibial muscular dystrophy DOID:0111078 OMIM:600334
 J:165576




Genotype
MGI:4838328
cx3
Allelic
Composition		 Capn3tm1Jsb/Capn3+
Ttntm1.1Isrd/Ttntm1.1Isrd
Genetic
Background		 involves: 129/Sv * 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Capn3tm1Jsb mutation (0 available); any Capn3 mutation (49 available)
Ttntm1.1Isrd mutation (0 available); any Ttn mutation (1457 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
muscle
dystrophic muscle ( J:165576 )
• especially in soleus and the tibialis anterior

cardiovascular system




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory