Phenotypes associated with this allele

• Allele Symbol: Wnt2^tm1Bjw
• Allele Name: targeted mutation 1, Brandon J Wainwright
• Allele ID: MGI:2177935
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Wnt2^tm1Bjw/Wnt2^tm1Bjw	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:2177939

Genotype
MGI:2177939

hm1

• Allelic Composition: Wnt2^tm1Bjw/Wnt2^tm1Bjw
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:36835 )

• ~50% of homozygotes die within 12-24 hrs of birth; surviving homozygotes are viable, fertile and healthy with no apparent heart or lung defects

• only 5 of 9 homozygotes delivered by Cesarean section survive the first 24 hrs due difficulties in breathing and nursing

embryo

abnormal placenta morphology ( J:36835 )

• a number of homozygotes delivered by Cesarean section display visible hematomas on the fetal side of term placentas

abnormal placenta vasculature ( J:36835 )

• in severely affected placentas, the number of fetal capillaries is reduced, indicating impaired vascularization

abnormal placenta labyrinth morphology ( J:36835 )

• at E14.5-E18.5, about 85% of mutant placentas exhibit generalized disruption of the labyrinthine zone and/or a reduction in the size and proportion of the labyrinthine zone

• by E18.5, severely affected placentas display several abnormally large blood pools and acellular fibrin deposits in the labyrinthine zone

abnormal placenta development ( J:36835 )

• at E14.5-E18.5, ~85% of mutant placentas show at least one defect, including edema and disruption of the labyrinthine zone, abnormally large and/or numerous maternal blood pools and/or a reduction in the size and proportion of the labyrinthine zone and the chorioallantoic plate region; however, no necrosis or apoptosis is observed

• notably, the number and distribution of trophoblast giant cells and spongiotrophoblast cells remains unaffected

growth/size/body

decreased body size ( J:36835 )

• newborn homozygotes exhibit runting

decreased body weight ( J:36835 )

• at birth, the average weight of homozygotes delivered by Cesarean section is 67% that of average wild-type weight

• at weaning, both male and female homozygotes weigh 85% of wild-type littermates

abnormal fetal growth/weight/body size ( J:36835 )

• at E14.5, homozygotes show a reduction in average body weight; however, this difference does not become significant until E17.5

cardiovascular system

abnormal placenta vasculature ( J:36835 )

• in severely affected placentas, the number of fetal capillaries is reduced, indicating impaired vascularization