Phenotypes associated with this allele

• Allele Symbol: Nyx^nob
• Allele Name: no b wave
• Allele ID: MGI:2177945
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nyx^nob/Nyx^nob	BALB/c-Nyx^nob	MGI:3055970
hm2	Nyx^nob/Nyx^nob	involves: BALB/cGr	MGI:3720062
ht3	Nyx^nob/Nyx^+	involves: BALB/cGr	MGI:5568984
ot4	Nyx^nob/Y	involves: BALB/cGr	MGI:3720065

Genotype
MGI:3055970

hm1

• Allelic Composition: Nyx^nob/Nyx^nob
• Genetic Background: BALB/c-Nyx^nob

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal eye electrophysiology ( J:50824 )

♀ • does not display electroretinographic (ERG) b-waves

♀ • ERG finding is observed by day 18

abnormal cone electrophysiology ( J:50824 )

♀ • light-adapted cone ERG retains a negative polarity

abnormal rod electrophysiology ( J:50824 )

♀ • dark-adapted rod ERG retains a negative polarity even with increasing stimulus intensity

absent visual evoked potential ( J:50824 )

♀ • no response to visual evoked potential at flash onset and slight response at flash offset

abnormal vision ( J:81028 )

♀ • decreased light sensitivity

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
congenital stationary night blindness 1A		DOID:0110870	OMIM:310500	J:50824

Genotype
MGI:3720062

hm2

• Allelic Composition: Nyx^nob/Nyx^nob
• Genetic Background: involves: BALB/cGr

vision/eye

abnormal cone electrophysiology ( J:123811 )

♀ • light adapted ERG is reduced in amplitude and has slower kinetics as compared to control

♀ • implicit time of the b-wave is delayed

♀ • cone ERG amplitude has a distinctive waveform as compared to control

abnormal rod electrophysiology ( J:123811 )

♀ • b-wave is absent in dark-adapted electroretinogram (ERG)

Genotype
MGI:5568984

ht3

• Allelic Composition: Nyx^nob/Nyx⁺
• Genetic Background: involves: BALB/cGr

vision/eye

abnormal rod electrophysiology ( J:209941 )

♀ • reduced b-wave in dark-adapted mice

Genotype
MGI:3720065

ot4

• Allelic Composition: Nyx^nob/Y
• Genetic Background: involves: BALB/cGr

vision/eye

abnormal cone electrophysiology ( J:123811 )

♂ • implicit time of the b-wave is delayed

♂ • light adapted ERG is reduced in amplitude and has slower kinetics as compared to control

♂ • cone ERG amplitude has a distinctive waveform as compared to control

abnormal rod electrophysiology ( J:123811 )

♂ • b-wave is absent in dark-adapted electroretinogram (ERG)