All Phenotypes F2<tm1Sjd> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	F2^tm1Sjd/F2^tm1Sjd	involves: 129P2/OlaHsd * Black Swiss	MGI:2177953
ht2	F2^tm1Sjd/F2⁺	involves: 129P2/OlaHsd	MGI:5140790
ht3	F2^tm1Jld/F2^tm1Sjd	involves: 129P2/OlaHsd * C57BL/6J	MGI:3831697
cn4	F2^tm1Jld/F2^tm1Sjd Tg(Mx1-cre)1Cgn/0	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA	MGI:3831696

Allelic Composition	F2^tm1Sjd/F2^tm1Sjd
Genetic Background	involves: 129P2/OlaHsd * Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F2^tm1Sjd mutation (0 available); any F2 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:48273 )

• mice that are born develop bleeding problems and die either within a few hours of birth or within 2 days of birth

postnatal lethality, complete penetrance ( J:48273 )

• Background Sensitivity: mice on a background enriched for Black Swiss survive until days 5 or 7

embryonic lethality during organogenesis, incomplete penetrance ( J:48273 )

• fewer than expected mice are alive at E10.5 through E11.5

digestive/alimentary system

intestinal hemorrhage ( J:48273 )

embryo

embryonic growth arrest ( J:48273 )

• in some mice at E10.5

decreased embryo size ( J:48273 )

• some embryos at E10.5

embryo tissue necrosis ( J:48273 )

• at E10.5, the degree of necrosis corresponds to severity of hemorrhaging

abnormal visceral yolk sac morphology ( J:48273 )

• at E9.5 to E12.5, some mice exhibit yolk sac vessels that are largely empty of blood and blood pools within the yolk sac cavity

• however, yolk sac blood vessels and membranes form normally

pale yolk sac ( J:48273 )

• in some mice between E9.5 and E12.5

cardiovascular system

distended pericardium ( J:48273 )

• in some mice between E9.5 and E11.5

hemorrhage ( J:48273 )

• neonates exhibit massive bleeding into the abdominal cavity, as well as bleeding into the intestinal lumen

• at E10.5, mice exhibit bleeding in the yolk sac cavity, exocoelomic cavity and pericardial sac unlike wild-type mice

hemopericardium ( J:48273 )

intestinal hemorrhage ( J:48273 )

homeostasis/metabolism

hemopericardium ( J:48273 )

impaired blood coagulation ( J:48273 )

• blood from E18.5 mice fails to clot

• however, addition of thrombin restores clotting

growth/size/body

decreased embryo size ( J:48273 )

• some embryos at E10.5

integument

purpura ( J:48273 )

• neonates exhibit purpura around the head, back, abdomen, and around joints

Allelic Composition	F2^tm1Sjd/F2⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F2^tm1Sjd mutation (0 available); any F2 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:174629 )

N	• mice exhibit normal bleed times and complete vessel occlusion following FeCl3 injury

Allelic Composition	F2^tm1Jld/F2^tm1Sjd
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F2^tm1Jld mutation (0 available); any F2 mutation (36 available)
F2^tm1Sjd mutation (0 available); any F2 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal blood coagulation ( J:144572 )

• clotting times are increased compared to in wild-type mice

increased bleeding time ( J:144572 )

• 11 of 16 mice exhibit modest increases in bleeding time compare to wild-type mice

• 5 of 16 mice fail to stop bleeding

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:144572 )

• following induction with poly(I:C)

cardiovascular system

abnormal heart morphology ( J:144572 )

• following induction with poly(I:C), hemorrhaging in the heart leads to muscle ischemia/necrosis, neutrophil infiltrates and early granulation tissue, and disruption of muscle architecture by amorphous plasma and matrix proteins

cardiac fibrosis ( J:144572 )

• aged uninduced mice develop hemosiderin depositions and cardiac fibrosis unlike wild-type mice

hemorrhage ( J:144572 )

• following induction with poly(I:C), nearly all mice exhibit cardiac hemorrhaging with some hemorrhaging in the pleural cavity (in 46% of mice), intracranial cavity (in 46% of mice), or focally within the skeletal muscle (in 18% of mice) unlike in wild-type mice

• however, without induction with poly(I:C) no hemorrhaging is observed

hemothorax ( J:144572 )

• following induction with poly(I:C), 46% of mice exhibit some hemorrhaging in the pleural cavity

testicular hemorrhage ( J:144572 )

• hemorrhaging is occasionally observed in the testes following induction with poly(I:C)

gastrointestinal hemorrhage ( J:144572 )

• hemorrhaging is occasionally observed in the bowels following induction with poly(I:C)

heart hemorrhage ( J:144572 )

• nearly all mice exhibit cardiac hemorrhaging following induction with poly(I:C)

• hemorrhaging in the heart leads to muscle ischemia/necrosis, neutrophil infiltrates and early granulation tissue, and disruption of muscle architecture by amorphous plasma and matrix proteins

intracranial hemorrhage ( J:144572 )

• following induction with poly(I:C), 46% of mice exhibit intracranial hemorrhaging; bleeding is often dural based with ventricular and parenchymal hemorrhaging occurring and parenchymal bleeding encountered in the medulla, cerebellum and hippocampus

cerebellum hemorrhage ( J:144572 )

• following induction with poly(I:C)

muscle hemorrhage ( J:144572 )

• following induction with poly(I:C), 18% of mice exhibit focal hemorrhaging within skeletal muscle

spinal hemorrhage ( J:144572 )

• hemorrhaging is occasionally observed in the spinal canal following induction with poly(I:C)

skin hemorrhage ( J:144572 )

• hemorrhaging is occasionally observed in the skin following induction with poly(I:C)

homeostasis/metabolism

abnormal blood coagulation ( J:144572 )

• clotting time is modestly increased compared to in wild-type mice

• following induction with poly(I:C), clotting time is severely increased compared to in wild-type mice

• however, platelet counts and fibrinogen amounts are normal, and treatment with prothrombin restores normal clotting times

increased bleeding time ( J:144572 )

• following induction with poly(I:C)

nervous system

intracranial hemorrhage ( J:144572 )

cerebellum hemorrhage ( J:144572 )

• following induction with poly(I:C)

spinal hemorrhage ( J:144572 )

• hemorrhaging is occasionally observed in the spinal canal following induction with poly(I:C)

integument

skin hemorrhage ( J:144572 )

• hemorrhaging is occasionally observed in the skin following induction with poly(I:C)

petechiae ( J:144572 )

• occasionally following induction with poly(I:C)

reproductive system

testicular hemorrhage ( J:144572 )

• hemorrhaging is occasionally observed in the testes following induction with poly(I:C)

respiratory system

hemothorax ( J:144572 )

• following induction with poly(I:C), 46% of mice exhibit some hemorrhaging in the pleural cavity

digestive/alimentary system

gastrointestinal hemorrhage ( J:144572 )

• hemorrhaging is occasionally observed in the bowels following induction with poly(I:C)

muscle

muscle hemorrhage ( J:144572 )

• following induction with poly(I:C), 18% of mice exhibit focal hemorrhaging within skeletal muscle

endocrine/exocrine glands

testicular hemorrhage ( J:144572 )

• hemorrhaging is occasionally observed in the testes following induction with poly(I:C)

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