Phenotypes associated with this allele

• Allele Symbol: F2^tm1Jes
• Allele Name: targeted mutation 1, J Evan Sadler
• Allele ID: MGI:2177949
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	F2^tm1Jes/F2^tm1Jes	involves: 129P2/OlaHsd * C57BL/6J	MGI:4943416

Genotype
MGI:4943416

hm1

• Allelic Composition: F2^tm1Jes/F2^tm1Jes
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality, incomplete penetrance ( J:48274 )

• 50% of mice die by E10.5

• most die between E14.5 and E18.5

neonatal lethality, complete penetrance ( J:48274 )

• mice die shortly after birth

lethality throughout fetal growth and development, incomplete penetrance ( J:48274 )

• most die between E14.5 and E18.5

embryonic lethality, incomplete penetrance ( J:48274 )

• 50% of mice die by E10.5

cardiovascular system

abnormal vitelline vasculature morphology ( J:48274 )

• enlarged capillaries in the yolk sac are fused into the venous plexus unlike in wild-type mice

hemorrhage ( J:48274 )

• intraperitoneal hemorrhage with no clottable blood

intracranial hemorrhage ( J:48274 )

• occasionally

integument

pallor ( J:48274 )

• at birth

embryo

abnormal vitelline vasculature morphology ( J:48274 )

• enlarged capillaries in the yolk sac are fused into the venous plexus unlike in wild-type mice

nervous system

intracranial hemorrhage ( J:48274 )

• occasionally