Phenotypes associated with this allele

• Allele Symbol: Srebf1^tm2Jdh
• Allele Name: targeted mutation 2, Jay D Horton
• Allele ID: MGI:2177958
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Srebf1^tm2Jdh/Srebf1^tm2Jdh	involves: 129S/SvEvBrd * C57BL/6	MGI:3801601

Genotype
MGI:3801601

hm1

• Allelic Composition: Srebf1^tm2Jdh/Srebf1^tm2Jdh
• Genetic Background: involves: 129S/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:43570 )

• only half of expected mice survive to adulthood

homeostasis/metabolism

decreased circulating cholesterol level ( J:43570 )

• slightly

decreased circulating triglyceride level ( J:43570 )

• slightly

increased liver cholesterol level ( J:43570 )

• 1.5-fold

liver/biliary system

increased liver cholesterol level ( J:43570 )

• 1.5-fold