Analysis Tools|
Allele Symbol Allele Name Allele ID |
Srebf1tm1Mbr targeted mutation 1, Michael S Brown MGI:2177959 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• leptin treatment decreased body weight and food intake to the same extent in mutant mice as in the cortol
• leptin treatment decreased SCD1 activity to the same degree as seen in wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the level of plasma cholesterol was significantly reduced in 8-10 weeks old male mice on normal diet
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• the level of plasma triglyceride was significantly reduced in 8-10 weeks old male mice on normal diet
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• the liver cholesterol content was significantly increased in 8-10 weeks old male mice on normal diet
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• the liver cholesterol content was significantly increased in 8-10 weeks old male mice on normal diet
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the level of plasma cholesterol was significantly reduced in 12 weeks old mice on normal diet
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• increase in the level of triglyceride in kedney with high fat diet seen in the control mice were prevented in mutant mice
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• the level of plasma triglyceride was significantly reduced in 12 weeks old mice on normal diet
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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