All Phenotypes Grin1<tm2.1Phs> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Grin1^tm2.1Phs
targeted mutation 2.1, Peter H Seeburg
MGI:2178084

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Grin1^tm2.1Phs/Grin1⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:3586702
ht2	Grin1^tm1Cur/Grin1^tm2.1Phs	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3586703

Allelic Composition	Grin1^tm2.1Phs/Grin1⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grin1^tm2.1Phs mutation (0 available); any Grin1 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:75497 )

• death within 4 weeks of birth

• 2/3 die with in the first 2 days after birth

behavior/neurological

abnormal food intake ( J:75497 )

• poor feeding

abnormal motor capabilities/coordination/movement ( J:75497 )

impaired righting response ( J:75497 )

decreased locomotor activity ( J:75497 )

growth/size/body

postnatal growth retardation ( J:75497 )

Allelic Composition	Grin1^tm1Cur/Grin1^tm2.1Phs
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grin1^tm1Cur mutation (0 available); any Grin1 mutation (66 available)
Grin1^tm2.1Phs mutation (0 available); any Grin1 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:75497 )

• death within 1 hour of birth

behavior/neurological

aphagia ( J:75497 )

• no feeding

respiratory system

respiratory distress ( J:75497 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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