All Phenotypes Gria2<tm1Phs> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gria2^tm1Phs
targeted mutation 1, Peter H Seeburg
MGI:2178124

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gria2^tm1Phs/Gria2^tm1Phs	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3845402

Allelic Composition	Gria2^tm1Phs/Gria2^tm1Phs
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gria2^tm1Phs mutation (0 available); any Gria2 mutation (77 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:50929 )

N	• reversal potential of inhibitory interneurons in dentate gyrus basket cells is the same as measured in wild-type cells

abnormal nervous system electrophysiology ( J:50929 )

• in vitro, reversal potential (in high Ca²⁺solution) of AMPA receptor-mediated currents of hippocampal CA1 pyramidal neurons is shifted to about -54 mV compared to the normal -70 mV; Ca²⁺ permeability in CA1 pyramidal neurons is elevated about 2-fold

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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