Phenotypes associated with this allele

• Allele Symbol: Gria2^tm1Phs
• Allele Name: targeted mutation 1, Peter H Seeburg
• Allele ID: MGI:2178124
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gria2^tm1Phs/Gria2^tm1Phs	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3845402

Genotype
MGI:3845402

hm1

• Allelic Composition: Gria2^tm1Phs/Gria2^tm1Phs
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:50929 )

N • reversal potential of inhibitory interneurons in dentate gyrus basket cells is the same as measured in wild-type cells

abnormal nervous system electrophysiology ( J:50929 )

• in vitro, reversal potential (in high Ca²⁺solution) of AMPA receptor-mediated currents of hippocampal CA1 pyramidal neurons is shifted to about -54 mV compared to the normal -70 mV; Ca²⁺ permeability in CA1 pyramidal neurons is elevated about 2-fold