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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gria2tm1.1Phs
targeted mutation 1.1, Peter H Seeburg
MGI:2178125
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gria2tm1.1Phs/Gria2tm1.1Phs involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 MGI:3845405
cn2
 		Adarb1tm1.1Skwa/Adarb1tm1.1Skwa
Gria2tm1.1Phs/Gria2tm1.1Phs
Tg(SLC18A3-cre)KMisa/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:4843115
cx3
 		Adarb1tm1Phs/Adarb1tm1Phs
Gria2tm1.1Phs/Gria2tm1.1Phs 		involves: 129S1/Sv * 129X1/SvJ MGI:3045882
cx4
 		Adarb1tm1Phs/Adarb1tm1Phs
Gria2tm1.1Phs/Gria2+ 		involves: 129S1/Sv * 129X1/SvJ MGI:3045883


Genotype
MGI:3845405
hm1
Allelic
Composition		 Gria2tm1.1Phs/Gria2tm1.1Phs
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gria2tm1.1Phs mutation (2 available); any Gria2 mutation (79 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:50929 )
N
• AMPA receptor mediated currents in hippocampal CA1 pyramidal neurons display current-voltage relations identical to wild-type; reversal potential of inhibitory interneurons in dentate gyrus basket cells is the same as measured in wild-type cells
• no differences are detected in brain architecture




Genotype
MGI:4843115
cn2
Allelic
Composition		 Adarb1tm1.1Skwa/Adarb1tm1.1Skwa
Gria2tm1.1Phs/Gria2tm1.1Phs
Tg(SLC18A3-cre)KMisa/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adarb1tm1.1Skwa mutation (0 available); any Adarb1 mutation (37 available)
Gria2tm1.1Phs mutation (2 available); any Gria2 mutation (79 available)
Tg(SLC18A3-cre)KMisa mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:164294 )
N
• mice exhibit normal motor function until 6 months of age

nervous system
nervous system phenotype ( J:164294 )
N
• motor neuron death observed in Adarb1tm1.1Skwa/Adarb1tm1.1Skwa Tg(SLC18A3-cre)KMisa mice is prevented




Genotype
MGI:3045882
cx3
Allelic
Composition		 Adarb1tm1Phs/Adarb1tm1Phs
Gria2tm1.1Phs/Gria2tm1.1Phs
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adarb1tm1Phs mutation (2 available); any Adarb1 mutation (37 available)
Gria2tm1.1Phs mutation (2 available); any Gria2 mutation (79 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:63273 )
• double homozygous null mice appear normal at all ages, as judged by food intake, weight increase, postnatal development, breeding and general behavior (full rescue)




Genotype
MGI:3045883
cx4
Allelic
Composition		 Adarb1tm1Phs/Adarb1tm1Phs
Gria2tm1.1Phs/Gria2+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adarb1tm1Phs mutation (2 available); any Adarb1 mutation (37 available)
Gria2tm1.1Phs mutation (2 available); any Gria2 mutation (79 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:63273 )
• compound mutant mice survive up to P35 (partial rescue; extended postnatal survival)




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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory