About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gria2tm1.1Phs
targeted mutation 1.1, Peter H Seeburg
MGI:2178125
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gria2tm1.1Phs/Gria2tm1.1Phs involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 MGI:3845405
cn2
 		Adarb1tm1.1Skwa/Adarb1tm1.1Skwa
Gria2tm1.1Phs/Gria2tm1.1Phs
Tg(SLC18A3-cre)KMisa/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:4843115
cx3
 		Adarb1tm1Phs/Adarb1tm1Phs
Gria2tm1.1Phs/Gria2tm1.1Phs 		involves: 129S1/Sv * 129X1/SvJ MGI:3045882
cx4
 		Adarb1tm1Phs/Adarb1tm1Phs
Gria2tm1.1Phs/Gria2+ 		involves: 129S1/Sv * 129X1/SvJ MGI:3045883


Genotype
MGI:3845405
hm1
Allelic
Composition		 Gria2tm1.1Phs/Gria2tm1.1Phs
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gria2tm1.1Phs mutation (2 available); any Gria2 mutation (79 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:50929 )
N
• no differences are detected in brain architecture
• AMPA receptor mediated currents in hippocampal CA1 pyramidal neurons display current-voltage relations identical to wild-type; reversal potential of inhibitory interneurons in dentate gyrus basket cells is the same as measured in wild-type cells




Genotype
MGI:4843115
cn2
Allelic
Composition		 Adarb1tm1.1Skwa/Adarb1tm1.1Skwa
Gria2tm1.1Phs/Gria2tm1.1Phs
Tg(SLC18A3-cre)KMisa/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adarb1tm1.1Skwa mutation (0 available); any Adarb1 mutation (37 available)
Gria2tm1.1Phs mutation (2 available); any Gria2 mutation (79 available)
Tg(SLC18A3-cre)KMisa mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:164294 )
N
• mice exhibit normal motor function until 6 months of age

nervous system
nervous system phenotype ( J:164294 )
N
• motor neuron death observed in Adarb1tm1.1Skwa/Adarb1tm1.1Skwa Tg(SLC18A3-cre)KMisa mice is prevented




Genotype
MGI:3045882
cx3
Allelic
Composition		 Adarb1tm1Phs/Adarb1tm1Phs
Gria2tm1.1Phs/Gria2tm1.1Phs
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adarb1tm1Phs mutation (2 available); any Adarb1 mutation (37 available)
Gria2tm1.1Phs mutation (2 available); any Gria2 mutation (79 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:63273 )
• double homozygous null mice appear normal at all ages, as judged by food intake, weight increase, postnatal development, breeding and general behavior (full rescue)




Genotype
MGI:3045883
cx4
Allelic
Composition		 Adarb1tm1Phs/Adarb1tm1Phs
Gria2tm1.1Phs/Gria2+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adarb1tm1Phs mutation (2 available); any Adarb1 mutation (37 available)
Gria2tm1.1Phs mutation (2 available); any Gria2 mutation (79 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:63273 )
• compound mutant mice survive up to P35 (partial rescue; extended postnatal survival)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory